• El oppidum del Cerro de Castarreño, Olmillos de Sasamón. Historiografía y arqueología de un hábitat fortificado de la segunda Edad del Hierro 

  García Sánchez, Jesús; Costa García, José Manuel (Institución Fernán González, 2019-09)

  Dominando la campiña segisamonense se encuentra el imponente Cerro de Castarreño (Olmillos de Sasamón). Aquí han podido identificarse en las últimas décadas evidencias arqueológicas que nos indican la existencia de un ...

• Direct protein quantification in complex sample solutions by surface-engineered nanorod probes 

  Schrittwieser, Stefan; Pelaz García, Beatriz; Parak, Wolfgang J.; Lentijo-Mozo, Sergio; Soulantica, Katerina; Dieckhoff, Jan; Ludwig, Frank; Schotter, Joerg (Springer Nature, 2017)

  Detecting biomarkers from complex sample solutions is the key objective of molecular diagnostics. Being able to do so in a simple approach that does not require laborious sample preparation, sophisticated equipment and ...

• Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo 

  Pérez-Hernández, Marta; Moros, María; Stepien, Grazyna; Pino, Pablo del; Menao, Sebastián; Heras, Marcelo de las; Arias, Maykel; Mitchell, Scott G.; Pelaz García, Beatriz; Gálvez, Eva M.; Martínez de la Fuente, Jesús; Pardo, Julián (BioMed Central, 2017)

  Background The special physicochemical properties of gold nanoprisms make them very useful for biomedical applications including biosensing and cancer therapy. However, it is not clear how gold nanoprisms may affect ...

• Nanoparticles engineered to bind cellular motors for efficient delivery 

  Dalmau-Mena, Inmaculada; Pino, Pablo del; Pelaz García, Beatriz; Cuesta-Geijo, Miguel Ángel; Galindo, Inmaculada; Moros, María; Martínez de la Fuente, Jesús; Alonso, Covadonga (BioMed Central, 2018)

  Background Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as ...

• Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases 

  Kalash, Leen; Val García, Cristina; Azuaje Guerrero, Jhonny Alberto; Loza García, María Isabel; Svensson, Fredrik; Zoufir, Azedine; Mervin, Lewis; Ladds, Graham; Brea Floriani, José Manuel; Glen, Robert; Sotelo Pérez, Eddy; Bender, Andreas (BioMed Central, 2017)

  Compounds designed to display polypharmacology may have utility in treating complex diseases, where activity at multiple targets is required to produce a clinical efect. In particular, suitable compounds may be useful in ...

Ver máis