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    • CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope 

      Skowera, Ania; Ellis, Richard J.; Varela Calviño, Rubén; Arif, Sefina; Huang, Guo Cai; Van-Krinks, Cassie; Zaremba, Anna; Rackham, Chloe; Allen, Jennifer S.; Tree, Timothy I. M.; Zhao, Min; Dayan, Colin M.; Sewell, Andrew K.; Unger, Wendy W.; Drijfhout, Jan W.; Ossendorp, Ferry; Roep, Bart O.; Peakman, Mark (American Society for Clinical Investigation, 2008)
      The final pathway of β cell destruction leading to insulin deficiency, hyperglycemia, and clinical type 1 diabetes is unknown. Here we show that circulating CTLs can kill β cells via recognition of a glucose-regulated ...





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