Now showing items 1-2 of 2

    • Full atomistic model of prion structure and conversion 

      Spagnolli, Giovanni; Rigoli, Marta; Orioli, Simone; Sevillano, Alejandro M.; Faccioli, Pietro; Wille, Holger; Biasini, Emiliano; Rodríguez Requena, Jesús (PLOS, 2019)
      Prions are unusual protein assemblies that propagate their conformationally-encoded information in absence of nucleic acids. The first prion identified, the scrapie isoform (PrPSc) of the cellular prion protein (PrPC), ...
    • Pharmacological inactivation of the prion protein by targeting a folding intermediate 

      Spagnolli, Giovanni; Massignan, Tania; Astolfi, Andrea; Biggi, Silvia; Rigoli, Marta; Brunelli, Paolo; Libergoli, Michela; Ianeselli, Alan; Orioli, Simone; Boldrini, Alberto; Terruzzi, Luca; Bonaldo, Valerio; Maietta, Giulia; López Lorenzo, Nuria; Fernández Flores, Leticia Camila; Bugallo Codeseira, Yaiza; Tosatto, Laura; Linsenmeier, Luise; Vignoli, Beatrice; Petris, Gianluca; Gasparotto, Dino; Pennuto, Maria; Guella, Graziano; Canossa, Marco; Altmeppen, Hermann C.; Lolli, Graziano; Biressi, Stefano; Martín Pastor, Manuel; Rodríguez Requena, Jesús; Mancini, Ines; Barreca, Maria L.; Faccioli, Pietro; Biasini, Emiliano (Springer Nature, 2021)
      Recent computational advancements in the simulation of biochemical processes allow investigating the mechanisms involved in protein regulation with realistic physics-based models, at an atomistic level of resolution. These ...





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