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    • Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis 

      Petljak, Mia; Alexandrov, Ludmil B.; Brammeld, Jonathan S.; Price, Stacey; Wedge, David C.; Grossmann, Sebastian; Dawson, Kevin J.; Ju, Young Seok; Ioro, Francesco; Castro Tubío, José Manuel; Koh, Ching Chiek; Georgakopoulos Soares, Ilias; Rodríguez Martín, Bernardo; Otlu, Burçak; O'Meara, Sarah; Butler, Adam P.; Menzies, Andrew; Bhosle, Shriram G.; Raine, Keiran; Jones, David R.; Teague, Jon W.; Beal, Kathryn; Latimer, Calli; O'Neill, Laura; Zamora Berna, Jorge Aurelio; Anderson, Elizabeth; Patel, Nikita; Maddison, Mark; Ng, Bee Ling; Graham, Jennifer; Garnett, Mathew J.; McDermott, Ultan; Nik Zainal, Serena; Campbell, Peter J.; Stratton, Michael R. (Elsevier, 2019)
      Multiple signatures of somatic mutations have beenidentified in cancer genomes. Exome sequences of1,001 human cancer cell lines and 577 xenograftsrevealed most common mutational signatures,indicating past activity of ...





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