Now showing items 1-4 of 4

    • Alternative Methodologies for the Synthesis of Substituted 3-arylcoumarins: Perkin Reactions and Palladium-Catalyzed Synthesis 

      Matos, Maria João Correia Pinto Carvalho de; Vázquez Rodríguez, Saleta; Borges, Fernanda; Uriarte Villares, Eugenio (MDPI, 2010)
      With the aim to find out the best methodology to prepare different series of substituted coumarins, thinking on their pharmacological evaluation, in the present communication we report the synthesis of 3-phenylcoumarin ...
    • Interest of 3-arylcoumarins as xanthine oxidase inhibitors 

      Matos, Maria João Correia Pinto Carvalho de; Borges, Fernanda; Santana Penín, María Lourdes; Uriarte Villares, Eugenio; Medda, Rosaria; Pintus, Francesca; Caboni, Martina; Era, Benedetta; Fais, Antonella; Petrillo, Amalia di (MDPI, 2015)
      In the current paper we studied the interest of a series of 3-arylcoumarin derivatives as xanthine oxidase inhibitors. For the best compound of the series, the 4’-methoxyphenyl-6-nitrocoumarin, it was determined the IC50 ...
    • Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives 

      Matos, Maria João Correia Pinto Carvalho de; Rodríguez Enríquez, Fernanda; Vilar, Santiago; Santana Penín, María Lourdes; Uriarte Villares, Eugenio; Hripcsak, George; Estrada, Martín; Rodríguez Franco, María Isabel; Viña Castelao, María Dolores (Elsevier, 2015)
      In this study we synthesized and evaluated a new series of amino and nitro 3-arylcoumarins as hMAO-A and hMAO-B inhibitors. Compounds 2, 3, 5 and 6 presented a better activity and selectivity profile against the hMAO-B ...
    • Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins 

      Matos, Maria João Correia Pinto Carvalho de; Pérez Cruz, Fernanda; Vázquez Rodríguez, Saleta; Uriarte Villares, Eugenio; Santana Penín, María Lourdes; Borges, Fernanda; Olea Azar, Claudio (Elsevier, 2013)
      In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1–9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical ...





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