Browsing by Subject "Alzheimer's disease"
Now showing items 1-7 of 7
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8‐Aminomethyl‐7‐hydroxy‐4‐methylcoumarins as Multitarget Leads for Alzheimer's Disease
(Wiley, 2016-07-22)This work is part of our ongoing research in the discovery of multitarget therapeutic agents for Alzheimer's disease (AD). A literature screening, based on our recently proposed pharmacophore, led to the identification of ... -
Benzoic acid-derived nitrones: a new class of potential acetylcholinesterase inhibitors and neuroprotective agents
(Elsevier, 2019)The discovery of new chemical entities endowed with potent and selective acetylcholinesterase (AChE) and/or butyrylcholinesterase (BChE) inhibitory activity is still a relevant subject for Alzheimer's disease therapy. ... -
Dendrimers reduce toxicity of Aβ 1-28 peptide during aggregation and accelerate fibril formation
(Elsevier, 2012-11)The influence of a GATG (gallic acid-triethylene glycol) dendrimer decorated with 27 terminal morpholine groups ([G3]-Mor) on the aggregation process of Alzheimer's peptide has been investigated. Amyloid fibrils were formed ... -
Design of optimal nonlinear network controllers for Alzheimer's disease
(PLOS, 2018-05-24)Brain stimulation can modulate the activity of neural circuits impaired by Alzheimer's disease (AD), having promising clinical benefit. However, all individuals with the same condition currently receive identical brain ... -
Estatinas en la prevención de la enfermedad de Alzheimer
(2021-06)Introducción: La enfermedad de Alzheimer (EA) tiene una carga epidemiológica y funcional muy elevada, cursa clínicamente como una degeneración cognitiva insidiosa y progresiva, y no se dispone en la actualidad de tratamiento ... -
Implicación del óxido nítrico en la patogénesis de la enfermedad de Alzheimer
(2020-11)La enfermedad de Alzheimer (EA) es una de las demencias neurodegenerativas primarias más prevalentes. Distintas hipótesis intentan explicar los mecanismos moleculares que conducen a esta patología. Una de las hipótesis ... -
Mismatch negativity (MMN) amplitude as a biomarker of sensory memory deficit in amnestic mild cognitive impairment
(Frontiers, 2013-11-20)It has been suggested that changes in some event-related potential (ERP) parameters associated with controlled processing of stimuli could be used as biomarkers of amnestic mild cognitive impairment (aMCI). However, data ...