Now showing items 1-7 of 7

    • 8‐Aminomethyl‐7‐hydroxy‐4‐methylcoumarins as Multitarget Leads for Alzheimer's Disease 

      Domínguez, José L.; Fernández-Nieto, Fernando; Brea Floriani, José Manuel; CATTO, Marco; Paleo, M. Rita; Porto, Silvia; Sardina, F. Javier; Castro, Marian; PISANI, Leonardo; Carotti, Angelo; Soto-Otero, Ramón; Méndez-Álvarez, Estefanía; Villaverde Cameron-Walker, María del Carmen; Sussman, Fredy Salomon (Wiley, 2016-07-22)
      This work is part of our ongoing research in the discovery of multitarget therapeutic agents for Alzheimer's disease (AD). A literature screening, based on our recently proposed pharmacophore, led to the identification of ...
    • Benzoic acid-derived nitrones: a new class of potential acetylcholinesterase inhibitors and neuroprotective agents 

      Oliveira, Catarina; Bagetta, Donatella; Cagide, Fernando; Teixeira, José; Amorim, Ricardo; Silva, Tiago; Garrido, Jorge; Remião, Fernando; Uriarte Villares, Eugenio; Oliveira, Paulo J.; Alcaro, Stefano; Ortuso, Francesco; Borges, Fernanda (Elsevier, 2019)
      The discovery of new chemical entities endowed with potent and selective acetylcholinesterase (AChE) and/or butyrylcholinesterase (BChE) inhibitory activity is still a relevant subject for Alzheimer's disease therapy. ...
    • Dendrimers reduce toxicity of Aβ 1-28 peptide during aggregation and accelerate fibril formation 

      Klajnert, Barbara; Wasiak, Tomasz; Ionov, Maksim; Fernández Villamarín, Marcos; Sousa Hervés, Ana; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Elsevier, 2012-11)
      The influence of a GATG (gallic acid-triethylene glycol) dendrimer decorated with 27 terminal morpholine groups ([G3]-Mor) on the aggregation process of Alzheimer's peptide has been investigated. Amyloid fibrils were formed ...
    • Design of optimal nonlinear network controllers for Alzheimer's disease 

      Sanchez-Rodriguez, Lazaro M; Iturria-Medina, Yasser; Baines, Erica A.; Mallo López, Sabela Carme; Dousty, Mehdy; Sotero, Roberto C. (PLOS, 2018-05-24)
      Brain stimulation can modulate the activity of neural circuits impaired by Alzheimer's disease (AD), having promising clinical benefit. However, all individuals with the same condition currently receive identical brain ...
    • Estatinas en la prevención de la enfermedad de Alzheimer 

      López-Grueiro Valcarce, Paula Teresa (2021-06)
      Introducción: La enfermedad de Alzheimer (EA) tiene una carga epidemiológica y funcional muy elevada, cursa clínicamente como una degeneración cognitiva insidiosa y progresiva, y no se dispone en la actualidad de tratamiento ...
    • Implicación del óxido nítrico en la patogénesis de la enfermedad de Alzheimer 

      Rodríguez González, Nerea (2020-11)
      La enfermedad de Alzheimer (EA) es una de las demencias neurodegenerativas primarias más prevalentes. Distintas hipótesis intentan explicar los mecanismos moleculares que conducen a esta patología. Una de las hipótesis ...
    • Mismatch negativity (MMN) amplitude as a biomarker of sensory memory deficit in amnestic mild cognitive impairment 

      Lindín Novo, Mónica; Correa Jaraba, Kenia Shaily; Zurrón Ocio, Montserrat; Díaz Fernández, Fernando (Frontiers, 2013-11-20)
      It has been suggested that changes in some event-related potential (ERP) parameters associated with controlled processing of stimuli could be used as biomarkers of amnestic mild cognitive impairment (aMCI). However, data ...





      Harvesters:Useful links:
      Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback