Browsing by Subject "Alzheimer’s disease"
Now showing items 1-9 of 9
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Estudo dos cambios na actividade eléctrica cerebral asociados ao declive na memoria de traballo visoespacial, no envellecemento san e no deterioro cognitivo leve
(2018)[GL] O deterioro cognitivo leve (DCL) é un estadio intermedio entre o envellecemento san e o que cursa con demencia. No presente estudo seleccionáronse dous grupos de participantes (Control san e DCL) nos que se estudaron ... -
Exploitation of Marine Molecules to Manage Alzheimer’s Disease
(MDPI, 2021)Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment ... -
Hesperidin as a neuroprotective agent: a review of animal and clinical evidence
(MDPI, 2019)Neuroprotection is the preservation of function and networks of neural tissues from damages caused by various agents, as well as neurodegenerative diseases such as Parkinson’s, Alzheimer’s, Huntington’s diseases, and ... -
Liver X receptor activation with an intranasal polymer therapeutic prevents cognitive decline without altering lipid levels
(ACS, 2021)The progressive accumulation of amyloid-beta (Aβ) in specific areas of the brain is a common prelude to late-onset of Alzheimer’s disease (AD). Although activation of liver X receptors (LXR) with agonists decreases Aβ ... -
New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
(Taylor & Francis, 2019)The design of multi-target directed ligands (MTDLs) is a valid approach for obtaining effective drugs for complex pathologies. MTDLs that combine neuro-repair properties and block the first steps of neurotoxic cascades ... -
A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice
(MDPI, 2020)Alzheimer’s disease (AD) is the leading cause of dementia. Non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist memantine improved cognition and molecular alterations after preclinical treatment. Nevertheless, ... -
Pharmacological Modulators of Tau Aggregation and Spreading
(MDPI, 2020)Tauopathies are neurodegenerative disorders characterized by the deposition of aggregates composed of abnormal tau protein in the brain. Additionally, misfolded forms of tau can propagate from cell to cell and throughout ... -
Robust hybrid deep learning models for Alzheimer’s progression detection
(Elsevier, 2021)The prevalence of Alzheimer’s disease (AD) in the growing elderly population makes accurately predicting AD progression crucial. Due to AD’s complex etiology and pathogenesis, an effective and medically practical solution ... -
Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif
(MDPI, 2016-03-17)The need for developing real disease-modifying drugs against neurodegenerative syndromes, particularly Alzheimer’s disease (AD), shifted research towards reliable drug discovery strategies to unveil clinical candidates ...