Now showing items 1-20 of 25

    • Accuracy of Molecular Biomarkers in Oral Fluids for Diagnosis of Periodontitis 

      Arias Bujanda, Nora Adriana (2020)
      The diagnosis of periodontitis is a critical element in the success of treatment. Traditional clinical measures have well-known limitations, requiring faster and more specific tools based on quantifiable biomarkers in oral ...
    • Análisis de aguas residuales con fines epidemiológicos: aplicaciones a la estimación del consumo de sustancias de abuso y en salud pública en general. Red española ESAR-Net 

      Bijlsma, Lubertus; Celma, Alberto; González Mariño, Iria; Postigo, Cristina; Andreu, Vicente; Andrés-Costa, María Jesús; Hernández, Félix; López de Alda, Miren; López-García, Ester; Marcé, Rosa María; Montes Goyanes, Rosa María; Pocurull, Eva; Picó, Yolanda; Rodil Rodríguez, María del Rosario; Rodríguez-Gil, Luis; Valcárcel, Yolanda; Quintana Álvarez, José Benito (España. Ministerio de Sanidad y Consumo, 2018-08-20)
      En este artículo se presenta la metodología de análisis de aguas residuales con fines epidemiológicos (wastewater-based epidemiology, WBE) y su potencial para abordar diversos aspectos relacionados con la salud pública. ...
    • Anti-CD26 autoantibodies are involved in rheumatoid arthritis and show potential clinical interest 

      Cordero Santamaría, Óscar Javier; Varela Calviño, Rubén; López González, Tania; Grujic, Milica; Juranic, Zorica; Mouriño, Coral; Hernández Rodríguez, Íñigo; Rodríguez López, Marina; Aspe de la Iglesia, Bruno; Pego Reigosa, José María (Elsevier, 2017-06-05)
      Objectives Rheumatoid arthritis (RA) patients show low serum levels of the Ag dipeptidyl peptidase IV (DPP-IV/CD26), both soluble CD26 (sCD26) concentration and its DPP-IV activity. The aim of this study was to test if ...
    • Cancer Salivary Biomarkers for Tumours Distant to the Oral Cavity 

      Rapado González, Óscar; Muinelo Romay, Laura; Majem, Blanca; López López, Rafael; Suárez Cunqueiro, María Mercedes (MDPI, 2016-08-08)
      The analysis of saliva as a diagnostic approach for systemic diseases was proposed just two decades ago, but recently great interest in the field has emerged because of its revolutionary potential as a liquid biopsy and ...
    • Caquexia tumoral: Identificación de marcadores y dianas moleculares 

      Franco Álvarez, Miguel (2021-06)
      La caquexia es un trastorno metabólico multifactorial caracterizado por la pérdida involuntaria de peso, principalmente a expensas de tejido muscular y adiposo, que afecta a de forma global más de la mitad de los pacientes ...
    • Cell-Free microRNAs as potential oral cancer biomarkers: from diagnosis to therapy 

      Rapado González, Óscar; López López, Rafael; López Cedrún, José Luis; Triana Martínez, Gabriel; Muinelo Romay, Laura; Suárez Cunqueiro, María Mercedes (MDPI, 2019)
      Oral cavity cancer is the most frequent malignancy of the head and neck. Unfortunately, despite educational interventions for prevention and early diagnosis, oral cancer patients are often diagnosed in advanced stages ...
    • Characterization of New Proteomic Biomarker Candidates in Mucopolysaccharidosis Type IVA 

      Álvarez González, José Víctor; Bravo López, Susana Belén; Chantada Vázquez, María del Pilar; Colón Mejeras, Cristóbal; Castro López, María José de; Morales, Montserrat; Vitoria, Isidro; Tomatsu, Shunji; Otero Espinar, Francisco Javier; Couce Pico, María de la Luz (MDPI, 2021)
      Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal storage disease caused by mutations in the N-acetylgalactosamine-6-sulfatase (GALNS) gene. Skeletal dysplasia and the related clinical features of MPS IVA are caused ...
    • Clinical study of cerebral small vessel disease 

      López Dequidt, Iria Alejandra (2019)
      Ageing and hypertension are the main causes of cerebral small vessel disease (SVD) known until today. Endothelial dysfunction, rupture of blood-brain barrier (BBB) and protein elimination failure angiopathy have become ...
    • Cognitive frailty: an update 

      Facal Mayo, David; Burgo, Clara; Spuch, Carlos; Gaspar, Pedro; Campos-Magdaleno, Maria (Frontiers Media, 2021)
      This review article provides an update of the empirical research on cognitive fragility conducted in the last four years. The studies retrieved were classified in four different categories. The first category includes ...
    • COPD and lung cancer: underdiagnosis and clinical characterization 

      Mouronte Roibás, Cecilia (2019)
      Both COPD and LC share their high mortality, tobacco history, genetic background, environmental exposure and other underlying mechanisms. The aim of this project is to establish COPD prevalence, as well as its underdiagnosis ...
    • DNA methylation changes in fibromyalgia suggest the role of the immune-inflammatory response and central sensitization 

      GERRA, MARIA CARLA; Carnevali, Davide; Ossola, Paolo; González-Villar, Alberto J.; Pedersen, Inge Søkilde; Triñanes, Yolanda; Donnini, Claudia; manfredini, matteo; Arendt-Nielsen, Lars; Carrillo de la Peña, María Teresa; Gerra, Maria Carla (MDPI, 2021)
      Fibromyalgia (FM) has been explained as a result of gene-environment interactions. The present study aims to verify DNA methylation differences in eleven candidate genome regions previously associated to FM, evaluating ...
    • DNA methylation changes in genes involved in inflammation and depression in fibromyalgia: a pilot study 

      GERRA, MARIA CARLA; Carnevali, Davide; Pedersen, Inge Søkilde; Donnini, Claudia; manfredini, matteo; González-Villar, Alberto J.; Triñanes, Yolanda; Pidal Miranda, Marina; Arendt-Nielsen, Lars; Carrillo de la Peña, María Teresa (De Gruyter, 2021)
      Objectives: The present pilot study aims to investigate DNA methylation changes of genes related to fibromyalgia (FM) development and its main comorbid symptoms, including sleep impairment, inflammation, depression and ...
    • Human salivary microRNAs in Cancer 

      Rapado González, Óscar; Majem, Blanca; Muinelo Romay, Laura; Álvarez Castro, Ana; Santamaría, Anna; Gil Moreno, Antonio; López López, Rafael; Suárez Cunqueiro, María Mercedes (Ivyspring International Publisher, 2018-01-06)
      Circulating microRNAs (miRNAs) have emerged as excellent candidates for cancer biomarkers. Several recent studies have highlighted the potential use of saliva for the identification of miRNAs as novel biomarkers, which ...
    • Increased Amplitude of the P3a ERP Component as a Neurocognitive Marker for Differentiating Amnestic Subtypes of Mild Cognitive Impairment 

      Correa Jaraba, Kenia Shaily; Lindín Novo, Mónica; Díaz Fernández, Fernando (Frontiers Media, 2018)
      The event-related potential (ERP) technique has been shown to be useful for evaluating changes in brain electrical activity associated with different cognitive processes, particularly in Alzheimer’s disease (AD). Longitudinal ...
    • Levels of Antioxidant Compound Glutathione in Moss from Industrial Areas 

      Varela Río, Zulema; Debén García, Sofía; Saxena, Dinesh K.; Aboal Viñas, Jesús Ramón; Fernández Escribano, José Ángel (MDPI, 2018-07)
      Plants possess a wide range of cellular mechanisms that help them tolerate potentially toxic substances. Several studies that were carried out under laboratory conditions have demonstrated that the antioxidant compound ...
    • Liquid Biopsies for Precision Medicine in Colorectal and Head and Neck Cancers: Saliva and Blood Biomarkers 

      Rapado González, Óscar (2022)
      Liquid biopsies have emerged as an innovative tool in precision oncology representing a valuable complement to traditional tumor biopsy for detecting, characterizing, and monitoring cancer. Liquid biopsies comprise the ...
    • Mismatch negativity (MMN) amplitude as a biomarker of sensory memory deficit in amnestic mild cognitive impairment 

      Lindín Novo, Mónica; Correa Jaraba, Kenia Shaily; Zurrón Ocio, Montserrat; Díaz Fernández, Fernando (Frontiers, 2013-11-20)
      It has been suggested that changes in some event-related potential (ERP) parameters associated with controlled processing of stimuli could be used as biomarkers of amnestic mild cognitive impairment (aMCI). However, data ...
    • Mitochondrial haplogroups define two phenotypes of osteoarthritis 

      Fernández Moreno, Mercedes; Soto Hermida, Ángel; Oreiro, Natividad; Pértega Díaz, Sonia; Fernández López, Carlos; Rego Pérez, Ignacio; Blanco García, Francisco Javier (Frontiers Media, 2012)
      Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA). Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; myeloperoxidase ...
    • Molecular Profiling of Circulating Tumour Cells Identifies Notch1 as a Principal Regulator in Advanced Non-Small Cell Lung Cancer 

      Mariscal, Javier; Alonso Nocelo, Marta; Muinelo Romay, Laura; Barbazán García, Jorge; Vieito, María; Abalo, Alicia; Gómez Tato, Antonio; Casares de Cal, María Ángeles; García-Caballero Parada, Tomás; Rodríguez, Carmela; Brozos, Elena; Baron, Francisco; López López, Rafael; Abal Posada, Miguel (Nature Publishing Group, 2016)
      Knowledge on the molecular mechanisms underlying metastasis colonization in Non-Small Cell Lung Cancer (NSCLC) remains incomplete. A complete overview integrating driver mutations, primary tumour heterogeneity and overt ...
    • Proteomic analysis and biochemical alterations in marine mussel gills after exposure to the organophosphate flame retardant TDCPP 

      Sánchez Marín, Paula; Vidal-Liñán, Leticia; Fernández González, Laura Emilia; Montes Goyanes, Rosa María; Rodil Rodríguez, María del Rosario; Quintana Álvarez, José Benito; Carrera, Mónica; Mateos, Jesús; Pérez Diz, Ángel; Beiras, Ricardo (Elsevier, 2021)
      Organophosphate flame retardants (OPFRs) are (re-)emergent environmental pollutants increasingly being used because of the restriction of other flame retardants. The chlorinated OPFR, tris(1,3-dichloro-2-propyl) phosphate ...





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