Browsing by Subject "Breast cancer"
Now showing items 1-15 of 15
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26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D3 (1,25D-d6) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines
(MDPI, 2013)It has been demonstrated that 1,25-dihydroxyvitamin D3 (1,25D) and some of its analogues have antitumor activity. 1,25D labeled with deuterium (26,26,26,27,27,27-hexadeuterated 1a,25-dihydroxyvitamin D3, or 1,25D-d6) is ... -
Analysis of a Real-World Cohort of Metastatic Breast Cancer Patients Shows Circulating Tumor Cell Clusters (CTC-clusters) as Predictors of Patient Outcomes
(MDPI, 2020)Circulating tumor cell (CTC) enumeration has emerged as a powerful biomarker for the assessment of prognosis and the response to treatment in metastatic breast cancer (MBC). Moreover, clinical evidences show that CTC-cluster ... -
Biopsia selectiva de ganglio centinela en quimioterapia neoadyuvante de cáncer de mama: una revisión bibliográfica
(2021-06)Introducción: el cáncer de mama es el más común en mujeres. Hoy en día disponemos de diversas opciones de manejo terapéutico que son discutidas con el propósito de mejorar los resultados obtenidos tras el tratamiento. Objetivo: ... -
CA15.3 Serum Concentrations in Older Women with Infiltrating Ductal Carcinomas of the Breast
(MDPI, 2014)Breast cancer is currently becoming a disease of the elderly. We have studied the relation between CA 15.3 serum concentrations and clinical-pathological parameters in 69 women with IDC aged over 70 years (76.3 ± 4.2; ... -
Cytotoxic Mechanism of Sphaerodactylomelol, an Uncommon Bromoditerpene Isolated from Sphaerococcus coronopifolius
(MDPI, 2021)Marine natural products have exhibited uncommon chemical structures with relevant antitumor properties highlighting their potential to inspire the development of new anticancer agents. The goal of this work was to study ... -
Estimación del riesgo poligénico de cáncer de mama en Galicia
(2020-07)El cáncer de mama constituye el tumor maligno más frecuente en las mujeres de todo el mundo. A pesar de la reducción considerable de su mortalidad a 5 años (<20%) asociada al gran avance de las técnicas de diagnóstico ... -
Functional Characterization of Circulating Tumour Cell (CTC) Clusters in Breast Cancer
(2021)Breast cancer (BC) is the most common malignancy in women and the second leading cause of cancer-related deaths. Most cancer-related deaths are due to metastasis, a process by which tumour cells spread to secondary sites. ... -
LIPG endothelial lipase and breast cancer risk by subtypes
(Springer Nature, 2021)Experimental data showed that endothelial lipase (LIPG) is a crucial player in breast cancer. However, very limited data exists on the role of LIPG on the risk of breast cancer in humans. We examined the LIPG-breast cancer ... -
Liquid biopsy: circulating tumor cells utility in precision medicine
(2019)Metastatic disease is the leading cause of cancer associated deaths. Circulating tumour cells (CTCs) are responsible for tumoral dissemination, as they are able to be released from the primary tumour and establish distal ... -
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine
(MDPI, 2020)A 1H-NMR-based metabolomic study was performed on MCF-7 cell lines treated with a novel nicotinamide derivative (DT-8) in comparison with two drugs characterized by a well-established mechanism of action, namely the ... -
PD-L1 testing based on the SP142 antibody in metastatic triple-negative breast cancer: summary of an expert round-table discussion
(Future Medicine, 2021)Triple-negative breast cancer (TNBC) is more aggressive than other breast cancer subtypes. TNBC is characterized by increased expression of Programmed Death-ligand 1 (PD-L1), a signal used by many tumors to escape the ... -
POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation
(Nature, 2021)Metabolic reprogramming is considered hallmarks of cancer. Aerobic glycolysis in tumors cells has been well-known for almost a century, but specific factors that regulate lactate generation and the effects of lactate in ... -
Rendimiento diagnóstico de la biopsia selectiva del ganglio centinela en el carcinoma ductal in situ de mama
(2020-06)La cirugía del cáncer de mama ha ido evolucionando desde un tratamiento localmente muy agresivo a tratamientos locales muy conservadores, con los mismos resultados oncológicos y con menor morbilidad y afectación estética, ... -
Variaciones en el Índice de Masa Corporal y adherencia a dieta mediterránea en cáncer de mama. Revisión sistemática
(2021-06)Introducción: El cáncer de mama es la neoplasia más frecuente en las mujeres. Algunos factores de riesgo que clásicamente se han asociado con este son: sexo femenino, antecedentes familiares, presencia de BRCA1 o BRCA2, ... -
Variantes genéticas de BRCA1 Y BRCA2
(2020-09)INTRODUCCIÓN Las mutaciones en los genes supresores de tumores de alta penetrancia BRCA1 y BRCA2 determinan el riesgo de desarrollo de cáncer de mama y cáncer de ovario a lo largo de la vida de un individuo, siendo genes ...