Now showing items 1-6 of 6

    • Assembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT‐Hook Adaptor 

      Learte Aymamí, Soraya; Rodríguez Villar, Jéssica; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2020)
      The nickel(II)‐mediated self‐assembly of a multimeric DNA binder is described. The binder is composed of two metal‐chelating peptides derived from a bZIP transcription factor (brHis2) and one short AT‐hook domain equipped ...
    • A bio-inspired hypoxia sensor using HIF1a-oxygen-dependent degradation domain 

      Iglesias, Pablo; Penas Tallón, Cristina; Barral Cagiao, Laura; Pazos Chantrero, Elena; Costoya Puente, José Antonio (Nature Publishing Group, 2019)
      Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. ...
    • Concurrent and orthogonal gold(I) and ruthenium(II) catalysis inside living cells 

      Vidal Vides, Cristian; Tomás Gamasa, María; Destito, Paolo; López García, Fernando; Mascareñas Cid, José Luis (Springer Nature, 2018)
      The viability of building artificial metabolic pathways within a cell will depend on our ability to design biocompatible and orthogonal catalysts capable of achieving non-natural transformations. In this context, transition ...
    • EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology 

      Brennecke, Philip; Rasina, Dace; Aubi, Oscar; Herzog, Katja; Landskron, Johannes; Cautain, Bastien; Vicente, Francisca; Quintana, Jordi; Mestres, Jordi; Stechmann, Bahne; Ellinger, Bernhard; Brea Floriani, José Manuel; Kolanowski, Jacek L.; Pilarsk, Radosław; Orzaez, Mar; Pineda-Lucena, Antonio; Laraia, Luca; Nam, Faranak; Zielenkiewicz, Piotr; Paruch, Kamil; Hansen, Espen; Kries, Jens P. von; Neuenschwander, Martin; Specker, Edgar; Bartunek, Petr; Simova, Sarka; Lesnikowski, Zbigniew; Krauss, Stefan; Lehtiö, Lari; Bilitewski, Ursula; Brönstrup, Mark; Taskén, Kjetil; Jirgensons, Aigars; Lickert, Heiko; Clausen, Mads H.; Andersen, Jeanette H.; Vicent, Maria J.; Genilloud, Olga; Martínez, Aurora; Nazaré, Marc; Fecke, Wolfgang; Gribbon, Philip (SAGE Publications, 2019)
      Compound screening in biological assays and subsequent optimization of hits is indispensable for the development of new molecular research tools and drug candidates. To facilitate such discoveries, the ...
    • Sequence‐Specific DNA Recognition with Designed Peptides 

      Boga, Sonia; Bouzada, David; García Peña, Diego; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Wiley, 2018)
      Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only ...
    • Transition metal catalysis in the mitochondria of living cells 

      Tomás Gamasa, María; Martínez Calvo, Miguel; Rodríguez Couceiro, José; Mascareñas Cid, José Luis (Nature Publishing Group, 2016-09-07)
      The development of transition metal catalysts capable of promoting non-natural transformations within living cells can open significant new avenues in chemical and cell biology. Unfortunately, the complexity of the cell ...

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