Now showing items 1-7 of 7

    • Antiangiogenic effects of coumarins against cancer: from chemistry to medicine 

      Majnooni, Mohammad Bagher; Fakhri, Sajad; Smeriglio, Antonella; Trombetta, Domenico; Croley, Courtney R.; Bhattacharyya, Piyali; Sobarzo Sánchez, Eduardo Marcelo; Farzaei, Mohammad Hosein; Bishayee, Anupam (MDPI, 2019)
      Angiogenesis, the process of formation and recruitment of new blood vessels from pre-existing vessels, plays an important role in the development of cancer. Therefore, the use of antiangiogenic agents is one of the most ...
    • In Silico Study of Coumarins and Quinolines Derivatives as Potent Inhibitors of SARS-CoV-2 Main Protease 

      Yañez, Osvaldo; Osorio, Manuel Isaías; Uriarte Villares, Eugenio; Areche, Carlos; Tiznado, William; Pérez Donoso, José M.; García Beltrán, Olimpio; González Nilo, Fernando (Frontiers, 2021)
      The pandemic that started in Wuhan (China) in 2019 has caused a large number of deaths, and infected people around the world due to the absence of effective therapy against coronavirus 2 of the severe acute respiratory ...
    • Practical, Large-Scale Preparation of Benzoxepines and Coumarins through Rhodium(III)-Catalyzed C–H Activation/Annulation Reactions 

      Gulías Costa, Moisés; Marcos Atanes, Daniel; Mascareñas Cid, José Luis; Font Molíns, Marc (American Chemical Society, 2019)
      Herein we disclose the assembly of benzoxepines and coumarins from 2-alkenylphenol precursors using [Cp*RhCl2]2 as the precatalyst and alkynes or carbon monoxide as reacting partners. The preparation of benzoxepines and ...
    • Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif 

      PISANI, Leonardo; Farina, Roberta; Soto-Otero, Ramón; DENORA, Nunzio; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio; CATTO, Marco; Carotti, Angelo (MDPI, 2016-03-17)
      The need for developing real disease-modifying drugs against neurodegenerative syndromes, particularly Alzheimer’s disease (AD), shifted research towards reliable drug discovery strategies to unveil clinical candidates ...
    • Structural Modifications on Natural-based Products: Synthetic Strategies and Biological Applications 

      Fonseca, André; Matos, Maria João Correia Pinto Carvalho de; Vázquez Rodríguez, Saleta; Viña Castelao, María Dolores; Vilar Varela, Santiago; Borges, Fernanda; Santana Penín, María Lourdes; Uriarte Villares, Eugenio (MDPI, 2015)
      Coumarins are a class of heterocyclic compounds present in a significant quantity in several plants. The simplest coumarin, a benzene ring fused with a pyran-2-one heterocycle, was first discovered in the 19th century and ...
    • Trending Topics on Coumarin and Its Derivatives in 2020 

      Carneiro Viqueira, Aitor; Matos, Maria João Correia Pinto Carvalho de; Uriarte Villares, Eugenio; Santana Penín, María Lourdes (MDPI, 2021)
      Coumarins are naturally occurring molecules with a versatile range of activities. Their structural and physicochemical characteristics make them a privileged scaffold in medicinal chemistry and chemical biology. Many ...
    • Tyrosinase inhibitor activity of coumarin-resveratrol hybrids 

      Fais, Antonella; Corda, Marcella; Era, Benedetta; Fadda, M. Benedetta; Matos, Maria João Correia Pinto Carvalho de; Quezada González, Elías Neftalí; Santana Penín, María Lourdes; Picciau, Carmen; Podda, Gianni; Delogu, Giovanna Lucia (MDPI, 2009)
      In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 ...

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