Browsing by Subject "Cyclization"
Now showing items 1-12 of 12
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Assembly of Tetrahydroquinolines and 2-Benzazepines by Pd-Catalyzed Cycloadditions Involving the Activation of C(sp3)–H Bonds
(American Chemical Society, 2021)Cycloaddition reactions are among the most practical strategies to assemble cyclic products; however, they usually require the presence of reactive functional groups in the reactants. Here, we report a palladium-catalyzed ... -
Catalytic Cyclization of o‐Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3‐Benzazepines
(Wiley, 2015)A novel osmium‐catalyzed cyclization of o‐alkynyl phenethylamines to give 3‐benzazepines is reported. The procedure allows the straightforward preparation of a broad range of dopaminergic 3‐benzazepine derivatives. Mechanistic ... -
Cyclization by Catalytic Ruthenium Carbene Insertion into Csp3-H Bonds
(Wiley, 2011)A novel tandem Ru-catalyzed carbene addition to terminal alkynes/insertion of Csp3–H bonds in alkynyl acetals, ethers and amines has been accomplished under mild conditions. This cascade provides an efficient approach to ... -
Iridium(I)-Catalyzed Intramolecular Cycloisomerization of Enynes: Scope and Mechanistic Course
(American Chemical Society, 2018-07-10)We report an Ir(I)-catalyzed cycloisomerization methodology that provides access to carbocyclic systems bearing exo-alkene moieties from alkynyl-equipped acyclic precursors. The method relies on the C–H activation of ... -
Nucleophilic Addition of Amines to Ruthenium Carbenes: ortho‐(Alkynyloxy)benzylamine Cyclizations towards 1,3‐Benzoxazines
(Wiley, 2015)A new ruthenium-catalyzed cyclization of ortho-(alkynyloxy)benzylamines to dihydro-1,3-benzoxazines is reported. The cyclization is thought to take place via the vinyl ruthenium carbene intermediates that are easily formed ... -
Oxidation of Alkynes via Catalytic Metal-Vinylidenes
(Thieme, 2020)Metal-vinylidenes, generated by treatment of terminal alkynes with transition metals, are very useful intermediates in modern synthetic chemistry as shown by the high number of transformations in which they are involved. ... -
Pd-Catalyzed (3 + 2) Heterocycloadditions between Alkylidenecyclopropanes and Carbonyls: Straightforward Assembly of Highly Substituted Tetrahydrofurans
(American Chemical Society, 2020)A Pd catalyst made from a Pd(0) source and a bulky biaryl phosphine ligand promotes highly efficient intramolecular (3 + 2) heterocycloadditions between alkylidenecyclopropanes (ACPs) and carbonyls. The annulations provide ... -
Recent Advances in Ruthenium-Catalyzed Carbene/Alkyne Metathesis (CAM) Transformations
(Thieme, 2020)Carbene intermediates have shown versatile applications in modern synthetic chemistry. Catalytic ruthenium carbene/alkyne metathesis (CAM) with readily available substrates renders an efficient procedure for the in situ ... -
Rh(III)-Catalyzed Tandem C-H Allylation and Oxidative Cyclization of Anilides: A New Entry to Indoles
(American Chemical Society, 2013)RhIII-catalyzed tandem C-H allylation and oxidative cyclization of anilides with allyl carbonates in the presence of a slight excess of AgSbF6 salt and Cu(OAc)2 as oxidant affords easy, economical access to important ... -
Rh(III)‐Catalyzed [5+1] Oxidative Cycloaddition of Arylguanidines with Alkynes: A Novel Access to C4‐Disubstituted 1,4‐ Dihydroquinazolin‐2‐amines
(Royal Society of Chemistry, 2015)A novel and mild RhIII-catalyzed [5+1] oxidative cycloaddition between arylguanidines and alkynes efficiently affords C4-disubstituted 1,4-dihydroquinazolin-2-amines. Members of this family of heterocycles, which contain ... -
Vinyl Dihydropyrans and Dihydrooxazines: Cyclizations of Catalytic Ruthenium Carbenes Derived from Alkynals and Alkynones
(Wiley, 2014)A novel synthesis of 2‐vinyldihydropyrans and dihydro‐1,4‐oxazines (morpholine derivatives) from alkynals and alkynones has been developed. The cyclizations require a mild generation of catalytic ruthenium carbenes from ... -
Vinyl Ruthenium Carbenes: Valuable Intermediates in Catalysis
(Springer, 2017)Vinyl ruthenium carbenes are easily prepared from the neutral Ru(II) complex Cp*RuCl(cod) in the presence of functionalized alkynes and diazoalkanes. These intermediates have been proposed for several transformations in ...