Browsing by Subject "Cyclodextrins"
Now showing items 1-7 of 7
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Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery
(MDPI, 2020)We previously developed two optimized formulations of dexamethasone acetate (DXMa) hydrogels by means of special cubic mixture designs for topical ocular administration. These gels were elaborated with hydroxypropyl-β-CD ... -
Cyclodextrin–Amphiphilic Copolymer Supramolecular Assemblies for the Ocular Delivery of Natamycin
(MDPI, 2019)Natamycin is the only drug approved for fungal keratitis treatment, but its low water solubility and low ocular penetration limit its efficacy. The purpose of this study was to overcome these limitations by encapsulating ... -
Not so rigid capsids based on cyclodextrin complexes: keys to design
(Elsevier, 2022)Membranes based on cyclodextrin complexes can be used as functional nanocarrier envelopers by chemical modifications of the cyclodextrin hydroxyl groups or by encapsulating different ligands in their cavities. Experiments: ... -
Remdesivir interactions with sulphobutylether-β-cyclodextrins: a case study using selected substitution patterns
(Elsevier, 2022)Modified cyclodextrins (CDs) consist of a distribution of different structures with different number and location of the substituted groups. Among the most important applications of these molecules is their use as an ... -
Rings, Hexagons, Petals, and Dipolar Moment Sink-Sources: The Fanciful Behavior of Water around Cyclodextrin Complexes
(MDPI, 2020)The basket-like geometry of cyclodextrins (CDs), with a cavity able to host hydrophobic groups, makes these molecules well suited for a large number of fundamental and industrial applications. Most of the established ... -
Supramolecular strategies for intracellular delivery and design of new thermoresponsive materials
(2020)In this Ph.D. dissertation, we have applied supramolecular strategies to promote intracellular delivery of diverse molecules and design potential thermoresponsive systems. Host-guest chemistry has been exploited to ... -
Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer
(MDPI, 2020)A new cyclodextrin polypseudorotaxanes nail lacquer (Regenail®) containing biotin, methyl sulphonyl methane (MSM), and dimethylsilanediol salicylate was developed and evaluated in vitro and in vivo. The product was developed ...