Browsing by Subject "DNA damage"

Now showing items 1-2 of 2

    • Cytotoxic Mechanism of Sphaerodactylomelol, an Uncommon Bromoditerpene Isolated from Sphaerococcus coronopifolius 

      Alves, Celso; Silva, Joana M.; Pinteus, Susete; Alonso López, Eva; Alvariño Romero, Rebeca; Duarte, Adriana; Marmitt, Diorge; Goettert, Márcia Inês; Gaspar, Helena; Alfonso Rancaño, María Amparo; Alpoim, Maria C.; Botana López, Luis Miguel; Pedrosa, Rui (MDPI, 2021)
      Marine natural products have exhibited uncommon chemical structures with relevant antitumor properties highlighting their potential to inspire the development of new anticancer agents. The goal of this work was to study ...

    • Ruthenation of Non‐stacked Guanines in DNA G‐Quadruplex Structures: Enhancement of c‐MYC Expression 

      Rodríguez Villar, Jéssica; Mosquera Mosquera, Jesús; Rodríguez Couceiro, José; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2016)
      Guanine quadruplexes (GQs) are compact four‐stranded DNA structures that play a key role in the control of a variety of biological processes, including gene transcription. Bulky ruthenium complexes featuring a bipyridine, ...




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