Browsing by Subject "Dendrimer"
Now showing items 1-6 of 6
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Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery
(Springer, 2012)During the last decades, great efforts have been devoted to design polymers for reducing the toxicity, increasing the absorption, and improving the release profile of drugs. Advantage has been also taken from the inherent ... -
Dendrimers reduce toxicity of Aβ 1-28 peptide during aggregation and accelerate fibril formation
(Elsevier, 2012-11)The influence of a GATG (gallic acid-triethylene glycol) dendrimer decorated with 27 terminal morpholine groups ([G3]-Mor) on the aggregation process of Alzheimer's peptide has been investigated. Amyloid fibrils were formed ... -
GATG Dendrimers and PEGylated Block Copolymers: from Synthesis to Bioapplications
(Springer, 2014)Dendrimers are synthetic macromolecules composed of repetitive layers of branching units that emerge from a central core. They are characterized by a tunable size and precise number of peripheral groups which determine ... -
Liver X receptor activation with an intranasal polymer therapeutic prevents cognitive decline without altering lipid levels
(ACS, 2021)The progressive accumulation of amyloid-beta (Aβ) in specific areas of the brain is a common prelude to late-onset of Alzheimer’s disease (AD). Although activation of liver X receptors (LXR) with agonists decreases Aβ ... -
Microwave Assisted Synthesis of Tripodal Tris(1H-1,2,3-triazol-4-yl) Cyanurates and Melamines
(MDPI, 2015)2,4,6-tris(prop-2-yn-1-yloxy)-1,3,5-triazine and N2,N4,N6-tri(prop-2-yn-1-yl)-1,3,5-triazine-2,4,6-triamine are used in click reactions to prepare tripodal compounds and dendrimer cores. So, 1,3-cycloaddition with benzyl ... -
Thermal Azide-Alkyne Cycloaddition (TAAC) as Efficient Clicked Chemistry Tool for the Functionalization of Dendrimers and Polymers
(2019)With the aim of exploring new methodologies for the functionalization of GATG dendrimers while taking advantage of their of decoration with terminal azides, we have focused on the thermal azide-alkyne cycloaddition (TAAC). ...