Now showing items 1-15 of 15

    • Biomaterials to suppress cancer stem cells and disrupt their tumoral niche 

      Garcia-Mazas, Carla; Csaba, Noemi; García-Fuentes, Marcos (Elsevier, 2017-05-25)
      Lack of improvement in the treatment options of several types of cancer can largely be attributed to the presence of a subpopulation of cancer cells with stem cell signatures and to the tumoral niche that supports and ...
    • Click Chemistry for Drug Delivery Nanosystems 

      Lallana, Enrique; Sousa Hervés, Ana; Fernández Trillo, Francisco (Springer, 2012)
      The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click ...
    • Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery 

      Lallana, Enrique; Fernández Trillo, Francisco; Sousa Hervés, Ana; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Springer, 2012)
      During the last decades, great efforts have been devoted to design polymers for reducing the toxicity, increasing the absorption, and improving the release profile of drugs. Advantage has been also taken from the inherent ...
    • Engineering Anisotropic Meniscus: Zonal Functionality and Spatiotemporal Drug Delivery 

      Abbadessa, Anna; Crecente Campo, José; Alonso Fernández, María José (2020)
      Human meniscus is a fibrocartilaginous structure that is crucial for an adequate performance of the human knee joint. Degeneration of the meniscus is often followed by partial or total meniscectomy, which enhances the risk ...
    • Engineering Anisotropic Meniscus: Zonal Functionality and Spatiotemporal Drug Delivery 

      Abbadessa, Anna; Crecente Campo, José; Alonso Fernández, María José (Mary Ann Liebert, 2020)
      Human meniscus is a fibrocartilaginous structure that is crucial for an adequate performance of the human knee joint. Degeneration of the meniscus is often followed by partial or total meniscectomy, which enhances the risk ...
    • GATG Dendrimers and PEGylated Block Copolymers: from Synthesis to Bioapplications 

      Sousa Hervés, Ana; Novoa Carballal, Ramón; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Springer, 2014)
      Dendrimers are synthetic macromolecules composed of repetitive layers of branching units that emerge from a central core. They are characterized by a tunable size and precise number of peripheral groups which determine ...
    • A Global View on Block Copolymers 

      Lazzari, Massimo; Torneiro Abuín, Mercedes (MDPI, 2020)
      In this systematic review, a total of 45,143 publications on block copolymers, issued between 1952 and 2019, are analyzed in terms of number, source, language, institution, country, keywords, and block copolymer type, to ...
    • Improvement of anterior and posterior segment ocular drug delivery: application in ocular cystinosis and age-related macular degeneration 

      Luaces Rodríguez, Andrea (2020)
      In this doctoral thesis, hydrogel-based formulations containing cysteamine of great potential for the treatment of ocular cystinosis have been developed. The hydrogel based on hyaluronic acid polymer has been extensively ...
    • In Vivo Theranostics at the Peri-Infarct Region in Cerebral Ischemia 

      Agulla Freire, Jesús; Brea López, David; Campos Pérez, Francisco; Sobrino Moreiras, Tomás; Argibay González, Bárbara; Al-Soufi, Wajih; Blanco González, Miguel; Castillo Sánchez, José Antonio; Ramos Cabrer, Pedro (Ivyspring International Publisher, 2014)
      The use of theranostics in neurosciences has been rare to date because of the limitations imposed on the free delivery of substances to the brain by the blood-brain barrier. Here we report the development of a theranostic ...
    • Intracellular Delivery of Biologically-Active Fungal Metabolite Gliotoxin Using Magnetic Nanoparticles 

      Comas, Laura; Polo Tobajas, Ester; Domingo, M. Pilar; Hernández, Yulán; Arias, Maykel; Esteban, Patricia; Martínez-Lostao, Luis; Pardo, Julián; Martínez de la Fuente, Jesús; Gálvez, Eva M. (MDPI, 2019)
      Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish ...
    • Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications 

      López Iglesias, Clara; Quílez, Cristina; Barros, Joana; Velasco, Diego; Álvarez Lorenzo, Carmen Isabel; Jorcano, José L.; Monteiro, Fernando J.; García González, Carlos A. (MDPI, 2020)
      The delivery of bioactive agents using active wound dressings for the management of pain and infections offers improved performances in the treatment of wound complications. In this work, solid lipid microparticles (SLMPs) ...
    • Nanoparticles engineered to bind cellular motors for efficient delivery 

      Dalmau-Mena, Inmaculada; Pino, Pablo del; Pelaz García, Beatriz; Cuesta-Geijo, Miguel Ángel; Galindo, Inmaculada; Moros, María; Martínez de la Fuente, Jesús; Alonso, Covadonga (BioMed Central, 2018)
      Background Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as ...
    • Nanoscale metal–organic frameworks as key players in the context of drug delivery: evolution toward theranostic platforms 

      Carrillo Carrión, Carolina (Springer, 2020-01)
      Metal–organic frameworks (MOFs) have emerged as one of the most fascinating libraries of porous materials with a huge potential in very diverse application areas. In particular, the bioanalytical and biomedical fields have ...
    • Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs 

      Cadete, Ana; Olivera, Ana; Besev, Magnus; Dhal, Pradeep; Gonçalves, Lídia; Almeida, António J.; Bastiat, Guillaume; Benoit, Jean-Pierre; Fuente, María de la; García Fuentes, Marcos; Alonso Fernández, María José; Torres López, María Dolores Ramona (Nature Publishing Group, 2019)
      Preparation of sophisticated delivery systems for nanomedicine applications generally involve multi-step procedures using organic solvents. In this study, we have developed a simple self-assembling process to prepare ...
    • Where in the cell is our cargo? Current methods to study intracellular cytosolic localization 

      Méndez Ardoy, Alejandro; Lostalé Seijo, Irene; Montenegro García, Javier (2018-09-03)
      The internalization and delivery of active substances into cells is a field of growing interest for chemical biology and therapeutics. As we move from small‐molecule based drugs towards bigger cargos, such as antibodies, ...





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