Now showing items 1-9 of 9

    • Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination 

      Pischedda, Sara; O’Connor, Daniel; Fairfax, Benjamin; Salas Ellacuriaga, Antonio; Martinón Torres, Federico; Pollard, Andrew J.; Trück, Johannes (Springer Nature, 2021)
      Background: Pneumococcal infections are a major cause of morbidity and mortality in young children and immaturity of the immune system partly underlies poor vaccine responses seen in the young. Emerging evidence suggests ...
    • Dientes para la estimación de la edad 

      Triñanes Ozores, Jorge (2021)
      La estimación de la edad es un parámetro muy valioso en el campo forense, que puede ser inferido a partir del ADN procedente de diversos tejidos biológicos. Tanto la genética forense como la antropología forense trabajan ...
    • Differential expression of snoRNAs in oral squamous cell carcinomas: new potential diagnostic markers 

      Chamorro Petronacci, Cintia Micaela; Pérez-Sayáns García, Mario; Padín Iruegas, María Elena; Marichalar Mendia, Xabier; Gallas Torreira, Mercedes; García García, Abel (Taylor & Francis, 2018-01-26)
      Background: Small nucleolar RNAs (snoRNAs) are small non-coding RNA sequences whose most studied function is ribosome biogenesis. The altered expression of snoRNA is observed in tumoral processes such as breast cancer and ...
    • DNA methylation changes in fibromyalgia suggest the role of the immune-inflammatory response and central sensitization 

      GERRA, MARIA CARLA; Carnevali, Davide; Ossola, Paolo; González-Villar, Alberto J.; Pedersen, Inge Søkilde; Triñanes, Yolanda; Donnini, Claudia; manfredini, matteo; Arendt-Nielsen, Lars; Carrillo de la Peña, María Teresa; Gerra, Maria Carla (MDPI, 2021)
      Fibromyalgia (FM) has been explained as a result of gene-environment interactions. The present study aims to verify DNA methylation differences in eleven candidate genome regions previously associated to FM, evaluating ...
    • DNA methylation changes in genes involved in inflammation and depression in fibromyalgia: a pilot study 

      GERRA, MARIA CARLA; Carnevali, Davide; Pedersen, Inge Søkilde; Donnini, Claudia; manfredini, matteo; González-Villar, Alberto J.; Triñanes, Yolanda; Pidal Miranda, Marina; Arendt-Nielsen, Lars; Carrillo de la Peña, María Teresa (De Gruyter, 2021)
      Objectives: The present pilot study aims to investigate DNA methylation changes of genes related to fibromyalgia (FM) development and its main comorbid symptoms, including sleep impairment, inflammation, depression and ...
    • Effects of Brassicaceae Isothiocyanates on Prostate Cancer 

      Novío Mallón, Silvia; CARTEA, ELENA; Soengas, Pilar; Freire Garabal, Manuel; Núñez-Iglesias, María Jesús (MDPI, 2016-05-12)
      Despite the major progress made in the field of cancer biology, cancer is still one of the leading causes of mortality, and prostate cancer (PCa) is one of the most encountered malignancies among men. The effective management ...
    • Epigenetic modulation of the immune system in early childhood: from infectious diseases to vaccines 

      Pischedda, Sara (2021)
      Epigenetic mechanisms regulate gene expression and transcription in a dynamic way. Many functional differences observed in the immune system of neonates and adults seem to be associated with epigenetic modifications of ...
    • Salivary DNA Methylation as an Epigenetic Biomarker for Head and Neck Cancer. Part I: A Diagnostic Accuracy Meta-Analysis 

      Rapado González, Óscar; Martínez Reglero, Cristina; Salgado Barreiro, Ángel; Muinelo Romay, Laura; López López, Rafael; Muinelo Lorenzo, Juan; López López, Rafael; Díaz Lagares, Ángel; Suárez Cunqueiro, María Mercedes (MDPI, 2021)
      DNA hypermethylation is an important epigenetic mechanism for gene expression inactivation in head and neck cancer (HNC). Saliva has emerged as a novel liquid biopsy representing a potential source of biomarkers. We performed ...
    • Transgenerational inheritance of chemical-induced signature: A case study with simvastatin 

      Neuparth, Teresa; Machado, André M.; Montes Goyanes, Rosa María; Rodil Rodríguez, María del Rosario; Barros, Susana; Alves, Nélson; Ruivo, Raquel; Castro, Luis Filipe; Quintana Álvarez, José Benito; Santos, Miguel Machado (Elsevier, 2020)
      The hypothesis that exposure to certain environmental chemicals during early life stages may disrupt reproduction across multiple non-exposed generations has significant implications for understanding disease etiology and ...

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