Now showing items 1-7 of 7

    • Heart Alterations after Domoic Acid Administration in Rats 

      Crespo Vieira, Andrés; Cifuentes Martínez, José Manuel; Bermúdez Pose, Roberto; Fernández Ferreiro, Sara; Román Castro, Albina; Botana López, Luis Miguel (MDPI AG, 2016-03-10)
      Domoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic alterations. DA effects are documented both in wildlife and experimental assays, showing that this toxin causes severe injuries ...
    • Immunohistochemical detection and gene expression of TNFα in turbot (Scophthalmus maximus) enteromyxosis 

      Ronza, Paolo; Bermúdez Pose, Roberto; Losada García, Ana Paula; Sitjà Bobadilla, Ariadna; Gómez Pardo, María Belén; Quiroga Berdeal, María Isabel (Elsevier, 2015)
      Enteromyxum scophthalmi (Myxozoa) constitutes one of the most devastating pathogens for turbot (Scophthalmus maximus, L.) aquaculture. This parasite causes a severe intestinal parasitosis that leads to a cachectic syndrome ...
    • Immunohistochemical expression of E–cadherin in different tissues of the teleost fish Scophthalmus maximus 

      Ronza, Paolo; Villamarín Cid, José Antonio; Méndez, Lucía; Gómez Pardo, María Belén; Bermúdez Pose, Roberto; Quiroga Berdeal, María Isabel (Elsevier, 2019)
      E–cadherin is an evolutionary conserved protein, whose main role as the principal component of adherens junctions is supporting epithelial cell–cell adhesion. It is an essential molecule for the maintenance of the epithelial ...
    • Oral Toxicity of Okadaic Acid in Mice: Study of Lethality, Organ Damage, Distribution and Effects on Detoxifying Gene Expression 

      Crespo Vieira, Andrés; Rubiolo Gaytán, Juan Andrés; López Alonso, Henar; Cifuentes Martínez, José Manuel; Alfonso Rancaño, María Amparo; Bermúdez Pose, Roberto; Otero Fuertes, María Paz; Rodríguez Vieytes, María Mercedes; Vega Lisi, Félix Víctor; Botana López, Luis Miguel (MDPI, 2013)
      In vivo, after administration by gavage to mice and rats, okadaic acid has been reported to produce lesions in liver, small intestine and forestomach. Because several reports differ in the damage detected in different ...
    • PD-L1 testing based on the SP142 antibody in metastatic triple-negative breast cancer: summary of an expert round-table discussion 

      Peg, Vicente; López García, María Ángeles; Comerma, Laura; Peiró, Gloria; García-Caballero Parada, Tomás; Concha López, Ángel; Suárez Gauthier, Ana; Ruiz, Irune; Rojo, Federico (Future Medicine, 2021)
      Triple-negative breast cancer (TNBC) is more aggressive than other breast cancer subtypes. TNBC is characterized by increased expression of Programmed Death-ligand 1 (PD-L1), a signal used by many tumors to escape the ...
    • The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy 

      Vázquez Fernández, Ester; Vos, Matthijn R.; Afanasyev, Pavel; Cebey, Lino; Sevillano Mantas, Alejandro Manuel; Vidal, Enric; Rosa, Isaac; Renault, Ludovic; Ramos, Adriana; Peters, Peter J.; Fernández, José Jesús; Van Heel, Marin; Young, Howard S.; Requena, Jesús R.; Wille, Holger (PLOS, 2016-09-08)
      The structure of the infectious prion protein (PrPSc), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and ...
    • The Teleost Thymus in Health and Disease: New Insights from Transcriptomic and Histopathological Analyses of Turbot, Scophthalmus maximus 

      Ronza, Paolo; Robledo Sánchez, Diego; Losada García, Ana Paula; Bermúdez Pose, Roberto; Gómez Pardo, María Belén; Martínez Portela, Paulino; Quiroga Berdeal, María Isabel (MDPI, 2020)
      The thymus is a primary lymphoid organ that plays a pivotal role in the adaptive immune system. The immunobiology of the thymus in fish is considered to be similar to that of mammals, but it is actually poorly characterized ...

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