Now showing items 1-5 of 5

    • Ferritin regulates organismal energy balanceand thermogenesis 

      Blankenhaus, Birte; Braza, Faouzi; Martins, Rui; Bastos Amador, Patricia; González García, Ismael; Carlos, Ana Rita; Mahu, Inês; Faisca, Pedro; Moura Nunes, Jose; Ventura, Pedro; Hoerr, Verena; Weis, Sebastian; Guerra, Joel; Cardoso, Silvia; Domingos, Ana I.; López Pérez, Miguel Antonio; Soares, Miguel P. (Elsevier, 2019)
      [ENG]Objective:The ferritin heavy/heart chain (FTH) gene encodes the ferroxidase component of the iron (Fe) sequestering ferritin complex, whichplays a central role in the regulation of cellular Fe metabolism. Here we ...
    • Inhibition of Mitochondrial Dynamics Preferentially Targets Pancreatic Cancer Cells with Enhanced Tumorigenic and Invasive Potential 

      Courtois, Sarah; Luxán Delgado, Beatriz de; Penin Peyta, Laure; Royo García, Alba; Pareja Alonso, Beatriz; Jagust, Petra; Alcalá, Sonia; Rubiolo Gaytán, Juan Andrés; Sánchez Piñón, Laura Elena; Sainz Anding, Bruno; Heeschen, Christopher; Sancho, Patricia (MDPI, 2021)
      Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest tumors, partly due to its intrinsic aggressiveness, metastatic potential, and chemoresistance of the contained cancer stem cells (CSCs). Pancreatic CSCs ...
    • Mitochondrial haplogroups define two phenotypes of osteoarthritis 

      Fernández Moreno, Mercedes; Soto Hermida, Ángel; Oreiro, Natividad; Pértega Díaz, Sonia; Fernández López, Carlos; Rego Pérez, Ignacio; Blanco García, Francisco Javier (Frontiers Media, 2012)
      Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA). Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; myeloperoxidase ...
    • New Mechanistic Insights on Carbon Nanotubes’ Nanotoxicity Using Isolated Submitochondrial Particles, Molecular Docking, and Nano-QSTR Approaches 

      González Durruthy, Michael; Concu, Riccardo; Ruso Veiras, Juan Manuel; Cordeiro, M. Natália D. S. (MDPI, 2021)
      Single-walled carbon nanotubes can induce mitochondrial F0F1-ATPase nanotoxicity through inhibition. To completely characterize the mechanistic effect triggering the toxicity, we have developed a new approach based on the ...
    • Phylogeography of the insular populations of common octopus, Octopus vulgaris Cuvier, 1797, in the Atlantic Macaronesia 

      Quinteiro Vázquez, Javier; Rodríguez Castro, Jorge; Rey Méndez, Manuel; González Henríquez, Nieves (Plos, 2020)
      Exploited, understudied populations of the common octopus, Octopus vulgaris Cuvier, 1797, occur in the northeastern Atlantic (NEA) throughout Macaronesia, comprising the Azores, Madeira and Canaries, and also the Cabo Verde ...

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