Now showing items 1-7 of 7

    • Assembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT‐Hook Adaptor 

      Learte Aymamí, Soraya; Rodríguez Villar, Jéssica; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2020)
      The nickel(II)‐mediated self‐assembly of a multimeric DNA binder is described. The binder is composed of two metal‐chelating peptides derived from a bZIP transcription factor (brHis2) and one short AT‐hook domain equipped ...
    • Custom‐Fit Ruthenium(II) Metallopeptides: A New Twist to DNA Binding With Coordination Compounds 

      Gamba, Ilaria; Salvadó, Iria; Rama, Gustavo; Bertazzon, Miriam; Sánchez López, Mateo Isidro; Sánchez-Pedregal, Víctor M.; Martínez Costas, José Manuel; Brissos, Rosa F.; Gamez, Patrick; Mascareñas Cid, José Luis; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Wiley, 2013)
    • Deciphering the H-Bonding Preference on Nucleoside Molecular Recognition through Model Copper(II) Compounds 

      Velo Gala, Inmaculada; Barceló Oliver, Miquel; Gil, Diego M.; González Pérez, Josefa María; Campos Castiñeiras; Castiñeiras Campos, Alfonso; Domínguez Martín, Alicia (MDPI, 2021)
      The synthetic nucleoside acyclovir is considered an outstanding model of the natural nucleoside guanosine. With the purpose of deepening on the influence and nature of non-covalent interactions regarding molecular recognition ...
    • Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras 

      Mosquera Mosquera, Jesús; Rodríguez Villar, Jéssica; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (WILEY-VCH Verlag GmbH, 2014-04-24)
      We report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor-groove DNA binders. The hybrid featuring the sequence of the native protein ...
    • Sequence‐Selective DNA Recognition with Peptide–Bisbenzamidine Conjugates 

      Sánchez López, Mateo Isidro; Vázquez Vázquez, Olalla; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2013)
      Transcription factors (TFs) are specialized proteins that play a key role in the regulation of genetic expression. Their mechanism of action involves the interaction with specific DNA sequences, which usually takes place ...
    • Single‐Molecule Approach to DNA Minor‐Groove Association Dynamics 

      Bordello Malde, Jorge; Sánchez López, Mateo Isidro; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis; Al-Soufi, Wajih; Novo Rodríguez, María de la Merced (Wiley, 2012)
      Getting in the groove: Fluorescence correlation spectroscopy reveals that the dynamics of the association process of the bisbenzamidine minor‐groove binder BBA‐OG (blue with green star, see scheme) to dsDNA is not controlled ...
    • Supramolecular strategies for intracellular delivery and design of new thermoresponsive materials 

      Fernández Caro, Héctor (2020)
      In this Ph.D. dissertation, we have applied supramolecular strategies to promote intracellular delivery of diverse molecules and design potential thermoresponsive systems. Host-guest chemistry has been exploited to ...

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