Now showing items 1-8 of 8

    • Co-delivery of RNAi and Chemokine by Polyarginine Nanocapsules Enables the Modulation of Myeloid-Derived Suppressor Cells 

      Martínez Ledo, Adriana; Sasso, Maria A.; Bronte, Vincenzo; Marigo, Ilaria; Boyd, Ben J.; García Fuentes, Marcos; Alonso Fernández, María José (Elsevier, 2019)
      Myeloid-Derived Suppressor Cells (MDSCs), immunosuppressive cells that promote tumor growth, represent an attractive target in cancer immunotherapy. However, the clinical success of this strategy is limited by the lack of ...
    • Engineering, on-demand manufacturing, and scaling-up ofpolymeric nanocapsules 

      Crecente Campo, José; Alonso Fernández, María José (Willey, 2019)
      Polymeric nanocapsules are versatile delivery systems with the capacity to load lipophilic drugs in their oily nucleus and hydrophilic drugs in their polymeric shell. The objective of this work was to expand the technological ...
    • Nanocarriers for the oral administration of therapeutic macromolecules 

      Santalices Ramos, Irene (2018)
      The main goal of this thesis has been the generation of knowledge towards the advancement of the oral administration of peptides. The specific objective has been to study how the composition and surface properties of ...
    • A new potential nano-oncological therapy based on polyamino acid nanocapsules 

      Gonzalo, Teresa; Lollo, Giovanna; García-Fuentes, Marcos; Torres, Dolores; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Calvo, Pilar; Avilés, Pablo; Guillén, Maria José; Alonso Fernández, María José (Elsevier, 2013-07)
      A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ...
    • Pegylated lipid nanocapsules with improved drug encapsulation and controlled release properties 

      Hervella, Pablo; Alonso-Sande, Maria; Ledo, Francisco; Lucero, Maria L.; Alonso Fernández, María José; García-Fuentes, Marcos (Bentham Science, 2014-05)
      Drugs with poor lipid and water solubility are some of the most challenging to formulate in nanocarriers, typically resulting in low encapsulation efficiencies and uncontrolled release profiles. PEGylated nano- capsules ...
    • Polymeric Nanocapsules for Vaccine Delivery: Influence of the Polymeric Shell on the Interaction With the Immune System 

      Peleteiro Olmedo, Mercedes; Presas, Elena; González Aramundiz, José Vicente; Sánchez Correa, Beatriz; Simón Vázquez, Rosana; Csaba, Noemi Stefania; Alonso Fernández, María José; González Fernández, África (Frontiers Media, 2018)
      The use of biomaterials and nanosystems in antigen delivery has played a major role in the development of novel vaccine formulations in the last few decades. In an effort to gain a deeper understanding of the interactions ...
    • Protamine nanocapsules as carriers for oral peptide delivery 

      Thwala, Lungile Nomcebo (2016-06-27)
      The use of nanotechnologies to develop nanocarriers for oral insulin delivery is one of the strategies that has received significant attention. The basis for this development has been that nanocarriers can protect the ...
    • Selective interaction of PEGylated polyglutamic acid nanocapsules with cancer cells in a 3D model of a metastatic lymph node 

      Alonso Nocelo, Marta; Abellán Pose, Raquel; Vidal Figueroa, Anxo; Abal Posada, Miguel; Csaba, Noemi Stefania; Alonso Fernández, María José; López López, Rafael; Fuente Freire, María de la (BioMed Central, 2016-06-23)
      Background Metastases are the most common reason of cancer death in patients with solid tumors. Lymph nodes, once invaded by tumor cells, act as reservoirs before cancer cells spread to distant organs. To address the ...





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