Browsing by Subject "Neurodegeneration"

Now showing items 1-5 of 5

    • Celia’s Encephalopathy (BSCL2-Gene-Related): Current Understanding 

      Sánchez Iglesias, Sofía; Fernández Pombo, Antía; Cobelo Gómez, Silvia; Hermida Ameijeiras, Álvaro; Alarcón Martínez, Helena; Domingo Jiménez, María Rosario; Ruiz Riquelme, Alejandro Iván; Rodríguez Requena, Jesús; Araújo Vilar, David (MDPI, 2021)
      Seipin, encoded by the BSCL2 gene, is a protein that in humans is expressed mainly in the central nervous system. Uniquely, certain variants in BSCL2 can cause both generalized congenital lipodystrophy type 2, upper and/or ...

    • Does Seipin Play a Role in Oxidative Stress Protection and Peroxisome Biogenesis? New Insights from Human Brain Autopsies 

      Sánchez Iglesias, Sofía; Fernández Liste, Alberto; Guillín Amarelle, Cristina; Rábano, Alberto; Rodríguez Cañete, Blanca Leticia; González Méndez, Blanca; Fernández Pombo, Antía; Senra, Ana; Araújo Vilar, David (Elsevier, 2019)
      Seipin is a widely expressed protein but with highest levels found in the brain and testes. Seipin function is not yet completely understood, therefore the aim of this study was to evaluate the expression of BSCL2 transcripts ...

    • Implicación del óxido nítrico en la patogénesis de la enfermedad de Alzheimer 

      Rodríguez González, Nerea (2020-11)
      La enfermedad de Alzheimer (EA) es una de las demencias neurodegenerativas primarias más prevalentes. Distintas hipótesis intentan explicar los mecanismos moleculares que conducen a esta patología. Una de las hipótesis ...

    • A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice 

      Companys Alemany, Júlia; Turcu, Andreea L.; Bellver Sanchis, Aina; Loza García, María Isabel; Brea Floriani, José Manuel; Canudas, Anna M.; Leiva, Rosana; Vázquez, Santiago; Pallàs, Mercè; Griñán Ferré, Christian (MDPI, 2020)
      Alzheimer’s disease (AD) is the leading cause of dementia. Non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist memantine improved cognition and molecular alterations after preclinical treatment. Nevertheless, ...

    • Renin angiotensin system and gender differences in dopaminergic degeneration 

      Rodríguez Pérez, Ana Isabel; Valenzuela Limiñana, Rita; Joglar, Belén; Garrido Gil, Pablo; Guerra Seijas, María Josefa Natividad; Labandeira García, José Luis (BMC, 2011)
      Background: There are sex differences in dopaminergic degeneration. Men are approximately two times as likely as premenopausal women of the same age to develop Parkinson’s disease (PD). It has been shown that the local renin ...




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