Browsing by Subject "Peptides"
Now showing items 1-12 of 12
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Assembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT‐Hook Adaptor
(Wiley, 2020)The nickel(II)‐mediated self‐assembly of a multimeric DNA binder is described. The binder is composed of two metal‐chelating peptides derived from a bZIP transcription factor (brHis2) and one short AT‐hook domain equipped ... -
Computational methods for the design and applications of self-assembled cyclic peptide nanotubes
(2021)During last decades, and enhanced by the development of the power of computers, Computational Chemistry has emerged as a powerful tool not only for complementing the work that experimental chemists carry out, but also ... -
Critical aggregation concentration for the formation of early Amyloid-β (1–42) oligomers
(Nature Publishing Group, 2018-01-29)The oligomers formed during the early steps of amyloid aggregation are thought to be responsible for the neurotoxic damage associated with Alzheimer’s disease. It is therefore of great interest to characterize this early ... -
Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos
(Wiley, 2016)We synthesized octa‐arginine conjugates of DNA‐binding agents (bisbenzamidine, acridine and Thiazole Orange) and demonstrated that their DNA binding and cell internalization can be inhibited by appending a (negatively ... -
Nickel-promoted recognition of long DNA sites by designed peptide derivatives
(WILEY-VCH Verlag GmbH, 2016-08-03)We describe the synthesis of designed peptidic modules that self-assemble in specific DNA sequences of 12 base pairs in the presence of NiII salts. The modules consist of modified fragments of transcription factors that ... -
Reversible supramolecular assembly at specific DNA sites: Ni-promoted, bivalent DNA binding with designed peptide and bipyridylbisbenzamidine components
(WILEY-VCH Verlag GmbH, 2014-07-15)At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped ... -
Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras
(WILEY-VCH Verlag GmbH, 2014-04-24)We report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor-groove DNA binders. The hybrid featuring the sequence of the native protein ... -
Sequence‐Selective DNA Recognition with Peptide–Bisbenzamidine Conjugates
(Wiley, 2013)Transcription factors (TFs) are specialized proteins that play a key role in the regulation of genetic expression. Their mechanism of action involves the interaction with specific DNA sequences, which usually takes place ... -
Sequence‐Specific DNA Recognition with Designed Peptides
(Wiley, 2018)Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only ... -
Stereoselective Formation of Chiral Metallopeptides
(Wiley, 2012-05-03)Playing into our hands: The achiral bipyridine amino acid fluorenylmethyloxycarbonyl 5‐amino‐3‐oxapentanoic acid (Fmoc‐O1PenBpy‐OH) has been used for the solid‐phase synthesis of metallopeptides. Circular dichroism, molecular ... -
Supramolecular Recognition and Selective Protein Uptake by Peptide Hybrids
(Wiley, 2018-04-27)The intracellular transport of exogenous proteins has emerged as one of the most promising methodologies for biotechnology and chemical biology. Current protein delivery is mainly approached by liposome encapsulation, ... -
Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers
(Wiley, 2012)Appending negatively charged Glu8 tails to a peptide dimer derived from the GCN4 transcription factor leads to an effective suppression of its DNA binding. The specific DNA recognition can be restored by irradiation with ...