Now showing items 1-19 of 19

    • Anion recognition and induced self-assembly of an alpha,gamma-cyclic peptide to form spherical clusters 

      Rodríguez-Vázquez, Nuria; Amorín López, Manuel; Granja Guillán, Juan Ramón; Alfonso, Ignacio (Wiley, 2016-03-21)
      A cyclic octapeptide composed of hydroxy-functionalized γ-amino acids folds in a "V-shaped" conformation that allows the selective recognition of anions such as chloride, nitrate, and carbonate. The process involves the ...
    • Assembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT‐Hook Adaptor 

      Learte Aymamí, Soraya; Rodríguez Villar, Jéssica; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2020)
      The nickel(II)‐mediated self‐assembly of a multimeric DNA binder is described. The binder is composed of two metal‐chelating peptides derived from a bZIP transcription factor (brHis2) and one short AT‐hook domain equipped ...
    • Custom‐Fit Ruthenium(II) Metallopeptides: A New Twist to DNA Binding With Coordination Compounds 

      Gamba, Ilaria; Salvadó, Iria; Rama, Gustavo; Bertazzon, Miriam; Sánchez López, Mateo Isidro; Sánchez-Pedregal, Víctor M.; Martínez Costas, José Manuel; Brissos, Rosa F.; Gamez, Patrick; Mascareñas Cid, José Luis; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Wiley, 2013)
    • In situ functionalized polymers for siRNA delivery 

      Martínez Costas, José Manuel; Fernández Trillo, Francisco; Montenegro García, Javier; Granja Guillán, Juan Ramón; Priegue Caamaño, Juan Manuel; Crisan, Daniel (WILEY-VCH Verlag GmbH, 2016-04-21)
      A new method is reported herein for screening the biological activity of functional polymers across a consistent degree of polymerization and in situ, that is, under aqueous conditions and without purification/isolation ...
    • Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos 

      Penas Tallón, Cristina; Sánchez López, Mateo Isidro; Guerra Varela, Jorge; Sánchez Piñón, Laura; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2016)
      We synthesized octa‐arginine conjugates of DNA‐binding agents (bisbenzamidine, acridine and Thiazole Orange) and demonstrated that their DNA binding and cell internalization can be inhibited by appending a (negatively ...
    • New designs of peptidic and polymeric vectors for protein and gene delivery 

      Juanes Carrasco, Marisa (2019)
      The expansion of new therapeutic technologies is limited by the effective, selective and controlled transport and release of the corresponding biomolecules to the different tissues, cells and organelles. Therefore, there ...
    • Recent Advances in Controlling the Internal and External Properties of Self‐Assembling Cyclic Peptide Nanotubes and Dimers 

      Rodríguez Vázquez, Nuria; Amorín López, Manuel; Granja Guillán, Juan Ramón (Royal Society of Chemistry, 2017-06-07)
      One of the most powerful strategies for the preparation of nanotubes is based on the stacking of flat-shaped cyclic peptide components. This strategy allows precise control of the nanotube internal diameter, the external ...
    • Reversible supramolecular assembly at specific DNA sites: Ni-promoted, bivalent DNA binding with designed peptide and bipyridylbisbenzamidine components 

      Sánchez López, Mateo Isidro; Mosquera Mosquera, Jesús; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (WILEY-VCH Verlag GmbH, 2014-07-15)
      At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped ...
    • Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras 

      Mosquera Mosquera, Jesús; Rodríguez Villar, Jéssica; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (WILEY-VCH Verlag GmbH, 2014-04-24)
      We report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor-groove DNA binders. The hybrid featuring the sequence of the native protein ...
    • Self-assembling alfa,gamma-cyclic peptides that generate cavities with tunable properties 

      Rodríguez Vázquez, Nuria; García Fandiño, Rebeca; Amorín López, Manuel; Granja Guillán, Juan Ramón (Royal Society of Chemistry, 2016-01-01)
      The design and synthesis of β-sheet-based self-assembling cyclic peptides with tunable cavities is described. The incorporation of a γ-amino acid with a hydroxyl group at C2 allows the incorporation of different groups ...
    • Self-assembling molecular capsules based on alpha, gamma-Cyclic peptides 

      Ozores, Lionel Haxel; Amorín López, Manuel; Granja Guillán, Juan Ramón (American Chemical Society, 2016-12-20)
      A new capsule based on a β-sheet self-assembling cyclic peptide with the ability to recognize and release several guests is described. The host structure is composed of two self-complementary α,γ-cyclic peptides bearing a ...
    • Self‐assembling Venturi‐like peptide nanotubes 

      Fuertes, Alberto; Ozores, Lionel Haxel; Amorín López, Manuel; Granja Guillán, Juan Ramón (Royal Society of Chemistry, 2017-01-14)
      We describe the design and synthesis of self-assembling peptide nanotubes that have an internal filter area and whose length and internal diameters, at the entrance and in the constricted area, are precisely controlled
    • Sequence Decoding of 1D to 2D Self-Assembling Cyclic Peptides 

      Díaz Arias, Sandra Natalia; Insua López, Ignacio; Bhak, Ghibom; Montenegro García, Javier (Wiley, 2020)
      The inherent ability of peptides to self-assemble with directional and rationally predictable interactions has fostered a plethora of synthetic two-dimensional (2D) supramolecular biomaterials. However, the design of ...
    • Sequence‐Specific DNA Recognition with Designed Peptides 

      Boga, Sonia; Bouzada, David; García Peña, Diego; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Wiley, 2018)
      Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only ...
    • Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics 

      Méndez Ardoy, Alejandro; Bayón Fernández, Alfonso; Yu, Ziyi; Abell, Chris; Granja Guillán, Juan Ramón; Montenegro García, Javier (Wiley, 2020)
      The recent advances in the supramolecular polymerization of synthetic building blocks in aqueous conditions has given rise to new artificial and biocompatible functional materials. However, despite the importance of spatially ...
    • Supramolecular strategies for intracellular delivery and design of new thermoresponsive materials 

      Fernández Caro, Héctor (2020)
      In this Ph.D. dissertation, we have applied supramolecular strategies to promote intracellular delivery of diverse molecules and design potential thermoresponsive systems. Host-guest chemistry has been exploited to ...
    • Synthetic Supramolecular Systems in Life-like Materials and Protocell Models 

      Insua López, Ignacio; Montenegro García, Javier (Elsevier, 2020)
      One of the biggest challenges in modern chemistry is the preparation of synthetic materials with life-like behavior for the assembly of artificial cells. In recent years, numerous artificial systems that mimic cellular ...
    • Thermodynamic and structural studies on the interaction of guests with macrocycles 

      Francisco, Vítor Manuel dos Santos (2014-02-06)
      This thesis describes the host-guest chemistry between different macrocycles with various guests in aqueous solution. The focus of this thesis is the influence of ionic molecules, which are typically neglected, in the ...
    • Tuning the properties of penetrating peptides by oxime conjugation 

      Pazo Pascual, Marta; Fernández Caro, Héctor; Priegue Caamaño, Juan Manuel; Lostalé Seijo, Irene; Montenegro García, Javier (Georg Thieme Verlag, 2017-01-25)
      We here describe the application of oxime bond formation between a peptide scaffold and different aldehydes to modify the transporting capabilities of penetrating peptides. We show that bonds such as oximes offer a great ...

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