Browsing by Subject "Zebrafish"
Now showing items 1-16 of 16
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Afferent Connectivity of the Zebrafish Habenulae
(Frontiers Media, 2016-04-26)The habenulae are bilateral nuclei located in the dorsal diencephalon that are conserved across vertebrates. Here we describe the main afferents to the habenulae in larval and adult zebrafish. We observe afferents from the ... -
Cell senescence contributes to tissue regeneration in zebrafish
(Wiley, 2020)Cellular senescence is a stress response that limits the proliferation of damaged cells by establishing a permanent cell cycle arrest. Different stimuli can trigger senescence but excessive production or impaired clearance ... -
Cellular and Molecular Mechanisms Underlying Glioblastoma and Zebrafish Models for the Discovery of New Treatments
(MDPI, 2021)Glioblastoma (GBM) is the most common of all brain malignant tumors; it displays a median survival of 14.6 months with current complete standard treatment. High heterogeneity, aggressive and invasive behavior, the impossibility ... -
Chronic environmentally relevant levels of simvastatin disrupt embryonic development, biochemical and molecular responses in zebrafish (Danio rerio)
(Elsevier, 2018-05-25)Simvastatin (SIM), a hypocholesterolaemic compound, is among the most prescribed pharmaceuticals for cardiovascular disease prevention worldwide. Several studies have shown that acute exposure to SIM causes multiple adverse ... -
Chronic exposure to environmentally relevant levels of simvastatin disrupts zebrafish brain gene signaling involved in energy metabolism
(Taylor & Francis, 2020)Simvastatin (SIM), a hypocholesterolaemic drug belonging to the statins group, is a widely prescribed pharmaceutical for prevention of cardiovascular diseases. Several studies showed that lipophilic statins, as SIM, cross ... -
Developmentally-programmed cellular senescence is conserved and widespread in zebrafish
(Impact Journals, 2020)Cellular senescence is considered a stress response imposing a stable cell cycle arrest to restrict the growth of damaged cells. More recently however, cellular senescence was identified during mouse embryo development at ... -
Emprego do peixe cebra (Danio rerio) coma modelo de estudo de neoplasias
(2019)Durante las últimas décadas el pez cebra se ha convertido en un organismo modelo importante en la investigación biomédica. Los avances técnicos han permitido generar modelos de cáncer en diferentes órganos del pez cebra, ... -
Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish
(MDPI, 2020)Autism Spectrum Disorders (ASD) affect around 1.5% of the global population, which manifest alterations in communication and socialization, as well as repetitive behaviors or restricted interests. ASD is a complex disorder ... -
HCT116 colorectal and MCF7 brest cancer cell lines xenografted into zebrafish embryos gives insight into the importance of microenviroment in tumor growth and metastasis for a future use of the model in clinical research
(2019)Zebrafish has emerged as one of the best models to characterize different human diseases due to his genetic similarity (75% of orthologous genes), and more specific, cancer. For this reason, zebrafish has been used in ... -
Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool
(Springer Nature, 2017)Background Zebrafish (Danio rerio) is a model organism that has emerged as a tool for cancer research, cancer being the second most common cause of death after cardiovascular disease for humans in the developed world. ... -
Modeling Cancer Using Zebrafish Xenografts: Drawbacks for Mimicking the Human Microenvironment
(MDPI, 2020)The first steps towards establishing xenografts in zebrafish embryos were performed by Lee et al., 2005 and Haldi et al., 2006, paving the way for studying human cancers using this animal species. Since then, the xenograft ... -
Morphological Abnormalities and Gene Expression Changes Caused by High Incubation Temperatures in Zebrafish Xenografts with Human Cancer Cells
(MDPI, 2021)Published studies show that most of the human cancer xenograft studies in zebrafish embryos have used incubation temperatures in the range of 32–34 °C for 3–6 days post-injection, trying to find a compromise temperature ... -
The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines
(MDPI, 2017)In the last few decades, the field of nanomedicine applied to cancer has revolutionized cancer treatment: several nanoformulations have already reached the market and are routinely being used in the clinical practice. In ... -
Zebrafish as a model organism for the study of toxicity and effectiveness of new antitumor therapies
(2020)The zebrafish have many advantages that led to be a model organism with a great potential in translational research. The zebrafish embryos are an ideal platform to evaluate novel cancer therapies. For this reason, the main ... -
Zebrafish Models of Autosomal Dominant Ataxias
(MDPI, 2021)Hereditary dominant ataxias are a heterogeneous group of neurodegenerative conditions causing cerebellar dysfunction and characterized by progressive motor incoordination. Despite many efforts put into the study of these ... -
Zebrafish Models of Autosomal Recessive Ataxias
(MDPI, 2021)Autosomal recessive ataxias are much less well studied than autosomal dominant ataxias and there are no clearly defined systems to classify them. Autosomal recessive ataxias, which are characterized by neuronal and ...