Browsing by Subject "Zebrafish"
Now showing items 1-9 of 9
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Afferent Connectivity of the Zebrafish Habenulae
(Frontiers Media, 2016-04-26)The habenulae are bilateral nuclei located in the dorsal diencephalon that are conserved across vertebrates. Here we describe the main afferents to the habenulae in larval and adult zebrafish. We observe afferents from the ... -
Cell senescence contributes to tissue regeneration in zebrafish
(Wiley, 2020)Cellular senescence is a stress response that limits the proliferation of damaged cells by establishing a permanent cell cycle arrest. Different stimuli can trigger senescence but excessive production or impaired clearance ... -
Chronic environmentally relevant levels of simvastatin disrupt embryonic development, biochemical and molecular responses in zebrafish (Danio rerio)
(Elsevier, 2018-05-25)Simvastatin (SIM), a hypocholesterolaemic compound, is among the most prescribed pharmaceuticals for cardiovascular disease prevention worldwide. Several studies have shown that acute exposure to SIM causes multiple adverse ... -
Chronic exposure to environmentally relevant levels of simvastatin disrupts zebrafish brain gene signaling involved in energy metabolism
(Taylor & Francis, 2020)Simvastatin (SIM), a hypocholesterolaemic drug belonging to the statins group, is a widely prescribed pharmaceutical for prevention of cardiovascular diseases. Several studies showed that lipophilic statins, as SIM, cross ... -
Emprego do peixe cebra (Danio rerio) coma modelo de estudo de neoplasias
(2019)Durante las últimas décadas el pez cebra se ha convertido en un organismo modelo importante en la investigación biomédica. Los avances técnicos han permitido generar modelos de cáncer en diferentes órganos del pez cebra, ... -
Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish
(MDPI, 2020)Autism Spectrum Disorders (ASD) affect around 1.5% of the global population, which manifest alterations in communication and socialization, as well as repetitive behaviors or restricted interests. ASD is a complex disorder ... -
HCT116 colorectal and MCF7 brest cancer cell lines xenografted into zebrafish embryos gives insight into the importance of microenviroment in tumor growth and metastasis for a future use of the model in clinical research
(2019)Zebrafish has emerged as one of the best models to characterize different human diseases due to his genetic similarity (75% of orthologous genes), and more specific, cancer. For this reason, zebrafish has been used in ... -
Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool
(Springer Nature, 2017)Background Zebrafish (Danio rerio) is a model organism that has emerged as a tool for cancer research, cancer being the second most common cause of death after cardiovascular disease for humans in the developed world. ... -
Zebrafish as a model organism for the study of toxicity and effectiveness of new antitumor therapies
(2020)The zebrafish have many advantages that led to be a model organism with a great potential in translational research. The zebrafish embryos are an ideal platform to evaluate novel cancer therapies. For this reason, the main ...