Now showing items 1-20 of 102

    • Accelerated inbreeding depression suggests synergistic epistasis for deleterious mutations in Drosophila melanogaster 

      Domínguez García, Sara; García Suárez, Carlos; Quesada, Humberto; Caballero Rúa, Armando (Nature Publishing Group, 2019)
      Epistasis may have important consequences for a number of issues in quantitative genetics and evolutionary biology. In particular, synergistic epistasis for deleterious alleles is relevant to the mutation load paradox and ...
    • Acute oral toxicity of tetrodotoxin in mice: determination of lethal dose 50 (LD50) and no observed adverse effect level (NOAEL) 

      Abal Camaño, Paula; Louzao Ojeda, María Carmen; Antelo Queijo, Álvaro; Alvarez, Mercedes; Cagide, Eva; Vilariño del Río, Natalia; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (Multidisciplinary Digital Publishing Institute (MDPI), 2017-02)
      Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the ...
    • An Expressed Sequence Tag (EST)-enriched genetic map of turbot (Scophthalmus maximus): a useful framework for comparative genomics across model and farmed teleosts 

      Bouza Fernández, María Carmen; Hermida Prieto, Miguel; Gómez Pardo, María Belén; Vera Rodríguez, Manuel; Fernández López, Carlos; Herrán Moreno, Roberto de la; Navajas Pérez, Rafael; Álvarez Dios, José Antonio; Gómez Tato, Antonio; Martínez Portela, Paulino (BMC, 2012)
      Background: The turbot (Scophthalmus maximus) is a relevant species in European aquaculture. The small turbot genome provides a source for genomics strategies to use in order to understand the genetic basis of productive ...
    • An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures 

      Collord, Grace; Tarpey, Patrick; Kurbatova, Natalja; Martincorena, Inigo; Morán, Sebastián; Castro, Manuel; Nagy, Tibor; Bignell, Graham; Maura, Francesco; Young, Matthew D.; Berna, Jorge; Castro Tubío, José Manuel; McMurran, Chris E.; Young, Adam M.H.; Sanders, Mathijs; Noorani, Imran; Price, Stephen J.; Watts, Colin; Leipnitz, Elke; Kirsch, Matthias; Schackert, Gabriele; Pearson, Danita; Devadass, Abel; Ram, Zvi; Collins, V. Peter; Allinson, Kieren; Jenkinson, Michael D.; Zakaria, Rasheed; Syed, Khaja; Hanemann, C. Oliver; Dunn, Jemma; McDermott, Michael W.; Kirollos, Ramez W.; Vassiliou, George S.; Esteller, Manel; Behjati, Sam; Brazma, Alvis; Santarius, Thomas; McDermott, Ultan (Nature Publishing Group, 2018)
      Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles ...
    • Analysis of qPCR reference gene stability determination methods and a practical approach for efficiency calculation on a turbot (Scophthalmus maximus) gonad dataset 

      Robledo Sánchez, Diego; Hernández Urcera, Jorge; Cal, Rosa; Gómez Pardo, María Belén; Sánchez Piñón, Laura Elena; Martínez Portela, Paulino; Viñas Díaz, Ana María (BMC, 2014)
      Background Gene expression analysis by reverse transcription quantitative PCR (qPCR) is the most widely used method for analyzing the expression of a moderate number of genes and also for the validation of microarray ...
    • Application of Pulsed Electric Fields for Obtaining Antioxidant Extracts from Fish Residues 

      Franco Ruiz, Daniel; Munekata, Paulo E. S.; Agregán Pérez, Rubén; Bermúdez Piedra, Roberto; López Pedrouso, María Dolores; Pateiro Moure, Mirian; Lorenzo Rodríguez, José Manuel (MDPI, 2020)
      Fish processing has serious economic and environmental costs in the food supply chain. It is necessary to find new ways to convert fish residue to added-value products, especially for main aquaculture species. In this ...
    • Assessing Community-Level and Single-Species Models Predictions of Species Distributions and Assemblage Composition after 25 Years of Land Cover Change 

      Bonthoux, Sébastien; Baselga Fraga, Andrés; Balent, Gérard (PLOS, 2013)
      To predict the impact of environmental change on species distributions, it has been hypothesized that community-level models could give some benefits compared to species-level models. In this study we have assessed the ...
    • Assessing Genetic Diversity for a Pre-Breeding Program in Piaractus mesopotamicus by SNPs and SSRs 

      Mastrochirico Filho, Vito Antonio; Pazo, Felipe del; Hata, Milene Elissa; Vanina Villanova, Gabriela; Foresti, Fausto; Vera Rodríguez, Manuel; Martínez Portela, Paulino; Porto Foresti, Fábio; Hashimoto, Diogo Teruo (MDPI, 2019)
      The pacu (Piaractus mesopotamicus) is a Neotropical fish with remarkable productive performance for aquaculture. Knowledge of genetic resources in Neotropical fish is essential for their applications in breeding programs. ...
    • Candidate transcriptomic sources of inbreeding depression in Drosophila melanogaster 

      García Suárez, Carlos; Ávila, Victoria; Quesada, Humberto; Caballero Rúa, Armando (PLOS, 2013)
      The genomic causes of inbreeding depression are poorly known. Several studies have found widespread transcriptomic alterations in inbred organisms, but it remains unclear which of these alterations are causes of the ...
    • Cell senescence contributes to tissue regeneration in zebrafish 

      Silva Álvarez, Sabela da; Guerra Varela, Jorge; Sobrido Cameán, Daniel; Quelle Regaldie, Ana; Barreiro Iglesias, Antón; Sánchez Piñón, Laura Elena; Collado, Manuel (Wiley, 2020)
      Cellular senescence is a stress response that limits the proliferation of damaged cells by establishing a permanent cell cycle arrest. Different stimuli can trigger senescence but excessive production or impaired clearance ...
    • Cell senescence is an antiviral defense mechanism 

      Baz-Martínez, Maite; Silva Álvarez, Sabela da; Rodríguez, Estefanía; Guerra Varela, Jorge; El Motiam, Ahmed; Vidal Figueroa, Anxo; García-Caballero Parada, Tomás; González Barcia, Miguel; Sánchez Piñón, Laura; Muñoz Fontela, Cesar; Collado, Manuel; Rivas Vázquez, Carmen (Nature Publishing Group, 2016)
      Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell ...
    • Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis 

      Petljak, Mia; Alexandrov, Ludmil B.; Brammeld, Jonathan S.; Price, Stacey; Wedge, David C.; Grossmann, Sebastian; Dawson, Kevin J.; Ju, Young Seok; Ioro, Francesco; Castro Tubío, José Manuel; Koh, Ching Chiek; Georgakopoulos Soares, Ilias; Rodríguez Martín, Bernardo; Otlu, Burçak; O'Meara, Sarah; Butler, Adam P.; Menzies, Andrew; Bhosle, Shriram G.; Raine, Keiran; Jones, David R.; Teague, Jon W.; Beal, Kathryn; Latimer, Calli; O'Neill, Laura; Zamora Berna, Jorge Aurelio; Anderson, Elizabeth; Patel, Nikita; Maddison, Mark; Ng, Bee Ling; Graham, Jennifer; Garnett, Mathew J.; McDermott, Ultan; Nik Zainal, Serena; Campbell, Peter J.; Stratton, Michael R. (Elsevier, 2019)
      Multiple signatures of somatic mutations have beenidentified in cancer genomes. Exome sequences of1,001 human cancer cell lines and 577 xenograftsrevealed most common mutational signatures,indicating past activity of ...
    • Climatic niche divergence drives patterns of diversification and richness among mammal families 

      Castro Ínsua, Adrián; Gómez Rodríguez, Carola; Wiens, John J.; Baselga Fraga, Andrés (Nature Publishing Group, 2018-06)
      A major goal of evolutionary biology is to understand why clades difer dramatically in species richness. A key to this challenge is to uncover the correlates of variation in diversifcation rate (speciation – extinction) ...
    • A combined strategy involving Sanger and 454 pyrosequencing increases genomic resources to aid in the management of reproduction, disease control and genetic selection in the turbot (Scophthalmus maximus) 

      Ribas, Laia; Gómez Pardo, María Belén; Fernández López, José Carlos; Álvarez Dios, José Antonio; Gómez Tato, Antonio; Quiroga Berdeal, María Isabel; Planas, Josep V.; Sitjà Bobadilla, Ariadna; Martínez Portela, Paulino; Piferrer, Francesc (BMC, 2013)
      Background: Genomic resources for plant and animal species that are under exploitation primarily for human consumption are increasingly important, among other things, for understanding physiological processes and ...
    • Community structure affects trophic ontogeny in a predatory fish 

      Sánchez-Hernández, Javier; Eloranta, Antti P.; Finstad, Anders G.; Amundsen, Per‐Arne (WILEY-BLACKWELL, 2017)
      While most studies have focused on the timing and nature of ontogenetic niche shifts, information is scarce about the effects of community structure on trophic ontogeny of top predators. We investigated how community ...
    • Conservation genetics of threatened Hippocampus guttulatus in vulnerable habitats in NW Spain: temporal and spatial stability of wild populations with flexible polygamous mating system in captivity 

      López Martínez, Almudena; Vera Rodríguez, Manuel; Planas, Miquel; Bouza Fernández, María Carmen (PLOS, 2015)
      This study was focused on conservation genetics of threatened Hippocampus guttulatus on the Atlantic coast of NW Iberian Peninsula. Information about spatial structure and temporal stability of wild populations was obtained ...
    • Construction and Annotation of a High Density SNP Linkage Map of the Atlantic Salmon (Salmo salar) Genome 

      Tsai, Hsin Y.; Robledo Sánchez, Diego; Lowe, Natalie R.; Bekaert, Michaël; Taggart, John; Bron, James; Houston, Ross (Genetics Society of America, 2016)
      High density linkage maps are useful tools for fine-scale mapping of quantitative trait loci, and characterization of the recombination landscape of a species’ genome. Genomic resources for Atlantic salmon (Salmo salar) ...
    • Cumulative effects of transgenerational induction on plant palatability to generalist and specialist herbivores 

      Neylan, Isabelle P.; Dirzo, Rodolfo; Sobral Bernal, María del Mar (Copernicus Publications, 2018-03)
      Herbivore damage can induce anti-herbivore traits in plants. However, there is little data regarding how these induced traits affect a plant’s palatability (an important factor in determining the likelihood and magnitude ...
    • Danio Rerio as Model Organism for Adenoviral Vector Evaluation 

      Gulías Otero, Paola; Guerra Varela, Jorge; González Aparicio, Manuela; Ricobaraza, Ana; Vales, Africa; González Aseguinolaza, Gloria; Hernández Alcoceba, Rubén; Sánchez Piñón, Laura Elena (MDPI, 2019)
      Viral vector use is wide-spread in the field of gene therapy, with new clinical trials starting every year for different human pathologies and a growing number of agents being approved by regulatory agencies. However, ...
    • Detection of growth-related QTL in turbot (Scophthalmus maximus) 

      Sánchez Molano, Enrique; Cerna, Álex; Toro Ibáñez, Miguel Ángel; Bouza Fernández, María Carmen; Hermida Prieto, Miguel; Gómez Pardo, María Belén; Cabaleiro, Santiago; Fernández Martín, Jesús; Martínez Portela, Paulino (BMC, 2011)
      Background The turbot (Scophthalmus maximus) is a highly appreciated European aquaculture species. Growth related traits constitute the main goal of the ongoing genetic breeding programs of this species. The recent ...





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