Browsing CIQUS-Artigos by Title
Now showing items 26-45 of 361
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A bio-inspired hypoxia sensor using HIF1a-oxygen-dependent degradation domain
(Nature Publishing Group, 2019)Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. ... -
Biocompatible Solvents and Ionic Liquid-Based Surfactants as Sustainable Components to Formulate Environmentally Friendly Organized Systems
(MDPI, 2021)In this review, we deal with the formation and application of biocompatible water-in-oil microemulsions commonly known as reverse micelles (RMs). These RMs are extremely important to facilitate the dissolution of hydrophilic ... -
Biodegradable PEG–dendritic block copolymers: synthesis and biofunctionality assessment as vectors of siRNA
(Royal Society of Chemistry, 2017-07-07)One important drawback of most of the currently used dendrimers for biomedical applications is their high stability under physiological conditions that can result in cytotoxicity or complications induced by the accumulation ... -
A C60-aryne building block: synthesis of a hybrid all-carbon nanostructure
(Royal Society of Chemistry, 2016-04-19)The synthesis of a [60]fullerene-benzyne building block and its further chemical cycloaddition reaction with graphene has resulted in a new all-carbon hybrid material which has been characterized by TGA, FTIR and Raman ... -
[C^N]‐Alkenyl Gold(III) Complexes by Proximal Ring‐Opening of (2‐Pyridyl)alkylidenecyclopropanes: Mechanistic Insights
(Wiley, 2020)Pyridine‐substituted alkylidenecyclopropanes (Py‐ACPs) react with gold(III) salts under mild reaction conditions through an unprecedented, proximal ring‐opening pathway, to generate highly appealing, catalytically active ... -
Calculation of the two-dimensional non-separable partition function for two molecular systems
(Springer, 2014-04-02)We present the application of an accurate quantum treatment, called two-dimensional non-separable (2D-NS), to the calculation of internal rotation partition functions of molecules with two rotors. This methodology involves ... -
Canonical DNA minor groove insertion of bisbenzamidine–Ru(ii) complexes with chiral selectivity
(Royal Society of Chemistry, 2019)We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor ... -
Catalytic addition of C–H bonds across C–C unsaturated systems promoted by iridium(i) and its group IX congeners
(Royal Society of Chemistry, 2020)Transition metal-catalyzed hydrocarbonations of unsaturated substrates have emerged as powerful synthetic tools for increasing molecular complexity in an atom-economical manner. Although this field was traditionally dominated ... -
Catalytic Asymmetric Synthesis of Butenolides and Butyrolactones
(American Chemical Society, 2017-06-22)γ-Butenolides, γ-butyrolactones, and derivatives, especially in enantiomerically pure form, constitute the structural core of numerous natural products which display an impressive range of biological activities which are ... -
Catalytic Cyclization of o‐Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3‐Benzazepines
(Wiley, 2015)A novel osmium‐catalyzed cyclization of o‐alkynyl phenethylamines to give 3‐benzazepines is reported. The procedure allows the straightforward preparation of a broad range of dopaminergic 3‐benzazepine derivatives. Mechanistic ... -
Chain-branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseases
(MDPI, 2019)Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) ... -
Characterizing aliphatic moieties in hydrocarbons with atomic force microscopy
(Royal Society of Chemistry, 2017)We designed and studied hydrocarbon model compounds by high-resolution noncontact atomic force microscopy. In addition to planar polycyclic aromatic moieties, these novel model compounds feature linear alkyl and ... -
A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC
(Royal Society of Chemistry, 2019)We describe the first chemical synthesis of a functional mutant of the DNA binding domain of the oncoprotein MYC, using two alternative strategies which involve either one or two Native Chemical Ligations (NCLs). Both ... -
Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct
(American Chemical Society, 2015)The first example of an ammonium derivative that causes a specific modification of the active site of type I dehydroquinase (DHQ1), a dehydratase enzyme that is a promising target for antivirulence drug discovery, is ... -
Chemical solution synthesis and ferromagnetic resonance of epitaxial thin films of yttrium iron garnet
(APS Physics, 2017)We report the fabrication of epitaxial Y 3 F e 5 O 12 (YIG) thin films on G d 3 G a 5 O 12 (111) using a chemical solution method. Cubic YIG is a ferrimagnetic material at room temperature, with excellent ... -
Chemo- and Regioselective Lysine Modification on Native Proteins
(American Chemical Society, 2018)Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods, based on synthetic and biochemical technologies, can achieve ... -
A chemosensor for dihydrogenphosphate based on an oxoazamacrocycle possessing three thiourea arms
(Royal Society of Chemistry, 2012)We report a new H-bond macrocyclic chromogenic chemosensor in organic media, H3L, which displayed drastic changes in its UV–vis spectra revealing selectivity for dihydrogenphosphate over other inorganic anions, such as ... -
Chiral Coalition in Helical Sense Enhancement of Copolymers: The Role of the Absolute Configuration of Comonomers
(American Chemistry Society, 2017-12-14)Both the role of the absolute configuration and the tendency of a chiral monomer to promote a certain helical scaffold in a polyphenylacetylene (PPA) —that depends on the conformational composition at the pendant group— ... -
Chiral gold–PPA nanocomposites with tunable helical sense and morphology
(Royal Society of Chemistry, 2020)A novel type of stimuli-responsive dynamic helical polymer–metal nanoparticle nanocomposite formed by a helical poly(phenylacetylene) (PPA) combined with gold nanoparticles (AuNPs) is described. Thus, several PPA copolymers ... -
Chiral information harvesting in helical poly(acetylene) derivatives using oligo(p-phenyleneethynylene)s as spacers
(Royal Society of Chemistry, 2020)A chiral harvesting transmission mechanism is described in poly(acetylene)s bearing oligo(p-phenyleneethynylene)s (OPEs) used as rigid achiral spacers and derivatized with chiral pendant groups. The chiral moieties induce ...