Browsing CIQUS-Artigos by Title
Now showing items 165-184 of 361
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Magnetic Field Induced Transition in Vanadium Spinels
(2014)We study vanadium spinels AV2O4 (A=Cd,Mg) in pulsed magnetic fields up to 65 T. A jump in magnetization at μ0H≈40 T is observed in the single-crystal MgV2O4, indicating a field induced quantum phase transition between ... -
Magnetically Recyclable Catalytic Carbon Nanoreactors
(Wiley, 2018-07-11)Multifunctional nanoreactors are assembled using hollow graphitized carbon nanofibers (GNFs) combined with nanocatalysts (Pd or Pt) and magnetic nanoparticles. The latter are introduced in the form of carbon‐coated cobalt ... -
Mapping a protein recognition centre with chiral photoactive ligands. An integrated approach combining photophysics, reactivity, proteomics and molecular dynamics simulation studies
(Royal Society of Chemistry, 2017-01-05)A multidisciplinary strategy to obtain structural information on the intraprotein region is described here. As probe ligands, (S)- and (R)-CPFMe (the methyl esters of the chiral drug carprofen) have been selected, while ... -
Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids
(American Chemical Society, 2013)The structural changes caused by the substitution of the aromatic moiety in (2S)-2-benzyl-3-dehydroquinic acids and its epimers in C2 by electron-withdrawing or electron-donating groups in type II dehydroquinase enzyme ... -
Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases
(Portland Press, 2014-03-15)DHQ2 (type II dehydroquinase), which is an essential enzyme in Helicobacter pylori and Mycobacterium tuberculosis and does not have any counterpart in humans, is recognized to be an attractive target for the development ... -
Membrane-disrupting iridium(III) oligocationic organometallopeptides
(Royal Society of Chemistry, 2016-08-19)A series of oligoarginine peptide derivatives containing cyclometallated iridium(III) units display remarkable cytotoxicity, comparable to that of cisplatin. In vitro studies with unilamellar vesicles support a membrane-disrupting ... -
Messenger RNA delivery by hydrazone-activated polymers
(Royal Society of Chemistry, 2019)The intracellular delivery of DNA and RNA therapeutics requires the assistance of vectors and/or nucleotide modifications to protect the nucleic acids against host nucleases and promote cellular internalization and release. ... -
Metal-Catalyzed annulations through activation and cleavage of C−H bonds
(WILEY-VCH Verlag GmbH, 2016-06-22)The exponential increase in the number of catalytic transformations that involve a metal-promoted activation of hitherto considered inert C−H bonds is promoting a fundamental change in the field of synthetic chemistry. ... -
Metal-catalyzed Cyclizations to Pyran and Oxazine Derivatives
(Thieme, 2016)Pyrans are privileged heterocyclic structures found in numerous natural compounds with extraordinary biological activities. The synthesis of these relevant structures has attracted a great deal of attention over the years. ... -
Metal-catalyzed uncaging of DNA-binding agents in living cells
(Royal Society of Chemistry, 2014)Attachment of alloc protecting groups to the amidine units of fluorogenic DNA-binding bisbenzamidines or to the amino groups of ethidium bromide leads to a significant reduction of their DNA affinity. More importantly, the ... -
Metal-Dependent DNA Recognition and Cell Internalization of Designed, Basic Peptides
(American Chemical Society, 2017)A fragment of the DNA basic region (br) of the GCN4 bZIP transcription factor has been modified to include two His residues at designed i and i+4 positions of its N-terminus. The resulting monomeric peptide (brHis2) does ... -
Methanol dimer formation drastically enhances hydrogen abstraction from methanol by OH at low temperature
(Royal Society of Chemistry, 2016-07-22)The kinetics of the reaction of methanol with hydroxyl radicals is revisited in light of the reported new kinetic data, measured in cold expansion beams. The rate constants exhibit an approximately 102-fold increase when ... -
Microspheres-prime/rMVA-boost vaccination enhances humoral and cellular immune response in IFNAR(−/−) mice conferring protection against serotypes 1 and 4 of bluetongue virus
(Elsevier, 2017-06)Bluetongue virus (BTV) is the causative agent of bluetongue disease (BT), which affects domestic and wild ruminants. At the present, 27 different serotypes have been documented. Vaccination has been demonstrated as one of ... -
Microwave-induced covalent functionalization of few-layer graphene with arynes under solvent-free conditions
(Royal Society of Chemistry, 2018)A non-conventional modification of exfoliated few-layer graphene (FLG) with different arynes under microwave (MW) irradiation and solvent-free conditions is reported. The described approach allows reaching fast, efficient ... -
MitoBlue as a tool to analyze the mitochondria-lysosome communication
(Springer Nature, 2020)MitoBlue is a fluorescent bisamidine that can be used to easily monitor the changes in mitochondrial degradation processes in different cells and cellular conditions. MitoBlue staining pattern is exceptional among mitochondrial ... -
MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
(American Chemical Society, 2014)We report the discovery of a fluorogenic dye, N1,N3-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high ... -
Moderately Strong Photoacid Dissociates in Alcohols with High Transient Concentration of the Proton-Transfer Contact Pair
(American Chemical Society, 2014)Proton transfer from strong photoacids to hydroxylic solvents is much under debate. Experimentally, the main issue stems from relaxation and diffusion processes that are concomitant with ultrafast proton transfer and blur ... -
Monitoring the Formation of Amyloid Oligomers Using Photoluminescence Anisotropy
(American Chemical Society, 2019-10)The formation of oligomeric soluble aggregates is related to the toxicity of amyloid peptides and proteins. In this manuscript, we report the use of a ruthenium polypyridyl complex ([Ru(bpy)2(dpqp)]2+) to track the formation ... -
MSpin‐JCoupling. A modular program for prediction of scalar couplings and fast implementation of Karplus relationships
(Wiley, 2018-05-17)MSpin‐JCoupling is a modular program for the prediction of scalar couplings using a large variety of Karplus relationships. The program was specially designed for small molecule analysis and can be run in graphical or ... -
Multidimensional Hamiltonian for tunneling with position-dependent mass
(APS Physics, 2014-09-15)A multidimensional Hamiltonian for tunneling is formulated, based on the mode with imaginary frequency of the transition state as a reaction coordinate. To prepare it for diagonalization, it is transformed into a lower-dimension ...