Browsing CIQUS-Artigos by Title
Now showing items 283-302 of 378
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Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras
(WILEY-VCH Verlag GmbH, 2014-04-24)We report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor-groove DNA binders. The hybrid featuring the sequence of the native protein ... -
Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides
(Royal Society of Chemistry, 2018)A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding ... -
Self-Assembled Micro-Fibres by Oxime Connection of Linear Peptide Amphiphiles
(Royal Society of Chemistry, 2018)Linear peptide amphiphiles are excellent biocompatible scaffolds for the hierarchical self-assembly of one dimensional nanostructures in aqueous media. However, their structural exploration and screening of self-assembling ... -
Self-assembling alfa,gamma-cyclic peptides that generate cavities with tunable properties
(Royal Society of Chemistry, 2016-01-01)The design and synthesis of β-sheet-based self-assembling cyclic peptides with tunable cavities is described. The incorporation of a γ-amino acid with a hydroxyl group at C2 allows the incorporation of different groups ... -
Self-assembling molecular capsules based on alpha, gamma-Cyclic peptides
(American Chemical Society, 2016-12-20)A new capsule based on a β-sheet self-assembling cyclic peptide with the ability to recognize and release several guests is described. The host structure is composed of two self-complementary α,γ-cyclic peptides bearing a ... -
Self-Assembly of Silver Metal Clusters of Small Atomicity on Cyclic Peptide Nanotubes
(American Chemical Society, 2015-10-06)Subnanometric noble metal clusters, composed by only a few atoms, behave like molecular entities and display magnetic, luminescent and catalytic activities. However, non-covalent interactions of molecular metal clusters, ... -
Self‐assembling Venturi‐like peptide nanotubes
(Royal Society of Chemistry, 2017-01-14)We describe the design and synthesis of self-assembling peptide nanotubes that have an internal filter area and whose length and internal diameters, at the entrance and in the constricted area, are precisely controlled -
Sequence Decoding of 1D to 2D Self-Assembling Cyclic Peptides
(Wiley, 2020)The inherent ability of peptides to self-assemble with directional and rationally predictable interactions has fostered a plethora of synthetic two-dimensional (2D) supramolecular biomaterials. However, the design of ... -
Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates
(Royal Society of Chemistry, 2015-02-18)Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to ... -
Sequence‐Selective DNA Recognition with Peptide–Bisbenzamidine Conjugates
(Wiley, 2013)Transcription factors (TFs) are specialized proteins that play a key role in the regulation of genetic expression. Their mechanism of action involves the interaction with specific DNA sequences, which usually takes place ... -
Sequence‐Specific DNA Recognition with Designed Peptides
(Wiley, 2018)Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only ... -
Sequential Induction of Chirality in Helical Polymers: From the Stereocenter to the Achiral Solvent
(American Chemical Society, 2018-04-13)Several steps of chiral induction have been detected in poly(phenylacetylene)s among their different hierarchical levels of chirality by vibrational circular dichroism, namely, (i) from the stereogenic centers to the ... -
Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery
(Royal Society of Chemistry, 2021)In this work we report a rational design strategy for the identification of new peptide prototypes for the non-disruptive supramolecular permeation of membranes and the transport of different macromolecular giant cargos. ... -
Simultaneous Adjustment of Size and Helical Sense of Chiral Nanospheres and Nanotubes Derived from Axially Racemic Poly(phenyl acetylene)s
(Wiley, 2016-10-19)Nanospheres and nanotubes with full control of their size and helical sense are obtained in chloroform from the axially racemic chiral poly(phenylacetylene) poly-(R)-1 using either Ag+ as both chiral inducer and cross-linking ... -
A Single Mutation is Sufficient to Modify the Metal Selectivity and Specificity of a Eukaryotic Manganese Superoxide Dismutase to Encompass Iron
(Wiley, 2018)We have generated a site‐directed mutant of the manganese superoxide dismutase SOD‐3 of C.elegans (MnSOD‐3) which modifies the metal specificity of the enzyme. While wild‐type MnSOD‐3 functions with manganese in the active ... -
Single spin localization and manipulation in graphene open-shell nanostructures
(Nature publishing group, 2019)Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion ... -
Single‐Molecule Approach to DNA Minor‐Groove Association Dynamics
(Wiley, 2012)Getting in the groove: Fluorescence correlation spectroscopy reveals that the dynamics of the association process of the bisbenzamidine minor‐groove binder BBA‐OG (blue with green star, see scheme) to dsDNA is not controlled ... -
Site-selective reversible Diels–Alder reaction between a biphenylene-based polyarene and a semiconductor surface
(Royal Society of Chemistry, 2018-04-28)Understanding the mechanisms involved in the covalent attachment of organic molecules to surfaces is a major challenge for nanotechnology and surface science. On the basis of classical organic chemistry mechanistic ... -
Skeletal diversity in Pt- and Au-catalyzed annulations of allenedienes: dissecting unconventional mechanistic pathways
(Royal Society of Chemistry, 2020)We describe the discovery of unprecedented annulation processes of 1,7-allenedienes, promoted by Pt or Au catalysts. These transformations revealed mechanistic pathways that had not been previously observed in reactions ... -
Some Guidelines for the Synthesis and Melting Characterization of Azide Poly(ethylene glycol) Derivatives
(MDPI, 2020)We provide fundamental guidelines in the form of a tutorial to be taken into account for the preparation and characterization of a specific class of poly(ethylene glycol) (PEG) derivatives, namely azide-terminated PEGs. ...