Now showing items 118-137 of 408

    • Ferroelectric Domain Walls in PbTiO3 Are Effective Regulators of Heat Flow at Room Temperature 

      Langenberg Pérez, Eric; Saha, Dipanjan; Holtz, Megan E.; Wang, Jian-Jun; Bugallo Ferrón, David; Ferreiro Vila, Elías; Paik, Hanjong; Hanke, Isabelle; Ganschow, Steffen; Muller, David A.; Chen, Long-Qing; Catalan, Gustau; Domingo, Neus; Malen, Jonathan; Schlom, Darrell G.; Rivadulla Fernández, José Francisco (American Chemical Society, 2019)
      Achieving efficient spatial modulation of phonon transmission is an essential step on the path to phononic circuits using “phonon currents”. With their intrinsic and reconfigurable interfaces, domain walls (DWs), ferroelectrics ...
    • Firefly luciferin precursor 2-cyano-6-hydroxybenzothiazole: Fluorescence à la carte controlled by solvent and acidity 

      Jadhav, Ankita S.; Carreira Blanco, Carlos; Fernández Rodríguez, Berta; González Fernández, Sonia; Malkhede, Dipalee D.; Mosquera González, Manuel; Ríos Rodríguez, María del Carmen; Rodríguez-Prieto, Flor (Elsevier, 2020)
      2-Cyano-6-hydroxybenzothiazole (CBTOH) is a key intermediate in the biosynthesis of D-luciferin, also used for its chemical synthesis and as luciferin bioluminescence precursor for chemical analysis. We characterized CBTOH ...
    • Fluorescence quenching of the N-methylquinolinium cation by pairs of water or alcohol molecules 

      Rodríguez-Prieto, Flor; Costa Corbelle, Carlos; Fernández Rodríguez, Berta; Ríos Rodríguez, M. Carmen; Mosquera González, Manuel (2018)
      N-Methylquinolinium cation (MQ+) in its first-excited singlet state is a strong oxidant commonly used as a photosensitizer, whose fluorescence is therefore quenched by electron donors. Interestingly, the fluorescence of ...
    • Fluorescence-Labeled Bis-benzamidines as Fluorogenic DNA Minor-Groove Binders: Photophysics and Binding Dynamics 

      Bordello Malde, Jorge; Sánchez López, Mateo Isidro; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis; Al-Soufi, Wajih; Novo Rodríguez, María de la Merced (WILEY-VCH Verlag GmbH, 2014-11-21)
      In recent decades there has been great interest in the design of highly sensitive sequence-specific DNA binders. The eligibility of the binder depends on the magnitude of the fluorescence increase upon binding, related to ...
    • A Folding-Based Approach for the Luminescent Detection of a Short RNA Hairpin 

      Penas Tallón, Cristina; Pazos Chantrero, Elena; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (American Chemical Society, 2013)
      We report the rational design of a 20-mer basic peptide, derived from the transcriptional antitermination protein N of bacteriophage P22, equipped with a luminescent DOTA[Tb3+] macrocyclic complex and a sensitizing tryptophan ...
    • Formation of Indoles, Dihydroisoquinolines and Dihydroquinolines by Ruthenium-Catalyzed Heterocyclizations 

      Varela Fernández, Alejandro; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (Thieme, 2012)
      Indoles, dihydroisoquinolines and dihydroquinolines were efficiently prepared by ruthenium-catalyzed heterocyclizations of aromatic homo- and bis-homopropargyl amines/amides in the presence of an amine/ammonium base-acid ...
    • Free-energy calculations for bioisosteric modifications of A3 adenosine receptor antagonists 

      Jandova, Zuzana; Jespers, Willem; Gutiérrez de Terán, Hugo; Sotelo Pérez, Eddy; Oostenbrink, Chris (MDPI, 2019)
      Adenosine receptors are a family of G protein-coupled receptors with increased attention as drug targets on different indications. We investigate the thermodynamics of ligand binding to the A3 adenosine receptor subtype, ...
    • Freezing the Dynamic Gap for Selectivity: Motion‐Based Design of Inhibitors of the Shikimate Kinase Enzyme 

      Prado, Verónica; Lence Quintana, Emilio José; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Wiley, 2016-10-04)
      Shikimate kinase (SK), the fifth enzyme of the aromatic amino acid biosynthesis, is a recognized target for antibiotic drug discovery. The potential of the distinct dynamic apolar gap, which isolates the natural substrate ...
    • From Oligo(Phenyleneethynylene) Monomers to Supramolecular Helices: The Role of Intermolecular Interactions in Aggregation 

      Fernández Rodríguez, Berta; Fernández Villar, Zulema; Quiñoá Cabana, Emilio; Freire Iribarne, Félix Manuel (MDPI, 2021)
      Supramolecular helices that arise from the self-assembly of small organic molecules via non-covalent interactions play an important role in the structure and properties of the corresponding materials. Here we study the ...
    • From Sergeants and Soldiers to Chiral Conflict Effects in Helical Polymers by Acting on the Conformational Composition of the Comonomers 

      Freire Iribarne, Félix Manuel; Cobos Cabrera, Scarlet Katherine; Rodríguez Riego, Rafael; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo (Wiley, 2020)
      Different communication mechanisms can be switched within a copolymer by acting on the conformational composition of the components and their chirality. Thus, a Sergeant and Soldiers effect is produced in two diastereomeric ...
    • Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms 

      Rodrigues Araújo, Ana Rita; Correa Chinea, Juan Francisco; Domínguez Arca, Vicente; Reis, Rui L.; Fernández Megía, Eduardo; Rodrigues Pires, Ricardo Alexandre (ACS Publications, 2021)
      The self-assembly of amyloid-β (Aβ) generates cytotoxic oligomers linked to the onset and progression of Alzheimer’s disease (AD). As many fundamental molecular pathways that control Aβ aggregation are yet to be unraveled, ...
    • Garment allergy caused by Disperse Blue 360: A new sensitizer 

      Pousa-Martínez, María; González Rodríguez, Carlos; Rodríguez-Rodríguez, Marta; Sainz-Gaspar, Laura; Sardina, F. Javier; Fernández-Redondo, Virginia (Wiley, 2018-02-15)
      Disperse dyes are some of the most common causes of textile contact dermatitis. Current legislation does not help to identify the colorant used in a garment
    • GATG Dendrimers and PEGylated Block Copolymers: from Synthesis to Bioapplications 

      Sousa Hervés, Ana; Novoa Carballal, Ramón; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Springer, 2014)
      Dendrimers are synthetic macromolecules composed of repetitive layers of branching units that emerge from a central core. They are characterized by a tunable size and precise number of peripheral groups which determine ...
    • A general route to chiral nanostructures from helical polymers: P/M switch via dynamic metal coordination 

      Arias, Sandra; Núñez Martínez, Manuel; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (Royal Society of Chemistry, 2017-05-16)
      A general method for the conversion of a polyphenylacetylene into its P or M helically oriented polymer, and into their corresponding P/M helical nanoparticles via dynamic metal coordination is presented. Addition of Mn+ ...
    • A Global View on Block Copolymers 

      Lazzari, Massimo; Torneiro Abuín, Mercedes (MDPI, 2020)
      In this systematic review, a total of 45,143 publications on block copolymers, issued between 1952 and 2019, are analyzed in terms of number, source, language, institution, country, keywords, and block copolymer type, to ...
    • Glycosyl Aldehydes: New Scaffolds for the Synthesis of Neoglycoconjugates via Bioorthogonal Oxime Bond Formation 

      Reina, José J.; Rioboo Vidal, Alicia; Montenegro García, Javier (Georg Thieme Verlag, 2018-01-02)
      The straightforward preparation of glycosyl neoconjugates by oxime (or hydrazone) bond formation represents a key bioorthogonal tool in chemical biology. However, when this strategy is employed by reacting the reducing end ...
    • Glycosylated Cell Penetrating Peptides, GCPPs 

      Gallego Gómez, Iván; Rioboo Vidal, Alicia; Reina, José J.; Díaz, Bernardo; Canales, Ángeles; Cañada, F. Javier; Guerra Varela, Jorge; Sánchez Piñón, Laura Elena; Montenegro García, Javier (Wiley, 2019-01-23)
      The cell membrane regulates the exchange of molecules and information with the external environment. However, this control barrier hinders the delivery of exogenous bioactive molecules that can be applied to correct cellular ...
    • Gold(I)-catalyzed [2 + 2 + 2] cycloaddition of allenamides, alkenes and aldehydes: a straightforward approach to tetrahydropyrans 

      Faustino, Hélio; Varela Sandá, Iván; Mascareñas Cid, José Luis; López García, Fernando (Royal Society of Chemistry, 2015-03-02)
      Allenamides participate as two-carbon components in an intermolecular [2 + 2 + 2] cycloaddition with alkenes and aldehydes when treated with catalytic amounts of a phosphite gold complex. The reaction is highly regio- and ...
    • Gold(I)-Catalyzed Enantioselective [2+2+2] Cycloadditions: An Expedient Entry to Enantioenriched Tetrahydropyran Scaffolds 

      Varela Sandá, Iván; Faustino, Hélio; Díez Martín, Elena; Iglesias Sigüenza, Francisco Javier; Grande-Carmona, Francisca; Fernández, Rosario; Lassaletta, José M.; Mascareñas Cid, José Luis; López García, Fernando (American Chemical Society, 2017-02-22)
      A straightforward and atom-economical enantioselective approach to highly substituted tetrahydropyrans is reported. The process, which consists of an intermolecular gold-catalyzed [2+2+2] cycloaddition between allenamides, ...
    • Gold(I)-catalyzed enantioselective cycloaddition reactions 

      López García, Fernando; Mascareñas Cid, José Luis (Beilstein-Institut, 2013)
      In recent years there have been extraordinary developments of gold(I)-catalyzed enantioselective processes. This includes progress in the area of cycloaddition reactions, which are of particular interest due to their ...





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