Now showing items 131-150 of 361

    • Hydroxybenzoic acid derivatives as dual-target ligands: mitochondriotropic antioxidants and cholinesterase inhibitors 

      Oliveira, Catarina; Cagide, Fernando; Teixeira, José; Amorim, Ricardo; Sequeira, Lisa; Mesiti, Francesco; Silva, Tiago; Garrido, Jorge; Remião, Fernando; Vilar Varela, Santiago; Uriarte Villares, Eugenio; Oliveira, Paulo J.; Borges, Fernanda (Frontiers Media, 2018)
      Alzheimer's disease (AD) is a multifactorial age-related disease associated with oxidative stress (OS) and impaired cholinergic transmission. Accordingly, targeting mitochondrial OS and restoring cholinergic transmission ...
    • Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme 

      Maneiro Rey, María; Lence Quintana, Emilio José; Sanz Gaitero, Marta; Otero Casas, José Manuel; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Royal Society of Chemistry, 2019)
      Targeted irreversible inhibitors bearing electrophiles that become activated towards covalent bond formation upon binding to a specific protein/enzyme is an emerging area in drug discovery. Targeting lysine residues is ...
    • IC-Tagging methodology applied to the expression of viral glycoproteins and the difficult-to-express membrane-bound IGRP autoantigen 

      Barreiro Piñeiro, Natalia; Lostalé Seijo, Irene; Varela Calviño, Rubén; Benavente Martínez, Francisco Javier; Martínez Costas, José Manuel (Springer Nature, 2018)
      We have previously developed a methodology to produce protein microspheres (MS) that can be loaded with proteins of interest in living cells through their C or N-terminal tagging with the so-called IC-Tag. The IC-Tagging ...
    • In situ detection of the protein corona in complex environments 

      Carril, Mónica; Prado, Daniel; Pino, Pablo del; Carrillo Carrión, Carolina; Gallego, Marta; Parak, Wolfgang J. (Springer Nature, 2017)
      Colloidal nanoparticles (NPs) are a versatile potential platform for in vivo nanomedicine. Inside blood circulation, NPs may undergo drastic changes, such as by formation of a protein corona. The in vivo corona cannot be ...
    • In situ functionalized polymers for siRNA delivery 

      Martínez Costas, José Manuel; Fernández Trillo, Francisco; Montenegro García, Javier; Granja Guillán, Juan Ramón; Priegue Caamaño, Juan Manuel; Crisan, Daniel (WILEY-VCH Verlag GmbH, 2016-04-21)
      A new method is reported herein for screening the biological activity of functional polymers across a consistent degree of polymerization and in situ, that is, under aqueous conditions and without purification/isolation ...
    • In situ nanofabrication of hybrid PEG-dendritic–inorganic nanoparticles and preliminary evaluation of their biocompatibility 

      Sousa Hervés, Ana; Sánchez Espinel, Christian; Fahmi, Amir; González-Fernández, África; Fernández Megía, Eduardo (Royal Society of Chemistry, 2015)
      An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal ...
    • In vivo degeneration and the fate of inorganic nanoparticles 

      Feliu, Neus; Docter, Dominic; Heine, Markus; Pino, Pablo del; Ashraf, Sumaira; Kolosnjaj-Tabi, Jelena; Macchiarini, Paolo; Nielsen, Peter; Alloyeau, Damien; Gazeau, Florence; Stauber, Roland H.; Parak, Wolfgang J. (Royal Society of Chemistry, 2016)
      What happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver, superparamagnetic iron oxide, or fluorescent quantum dot NPs after they have been administrated to a living being? This review discusses ...
    • In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains 

      Sánchez López, Mateo Isidro; Martínez Costas, José Manuel; González García, Francisco; Álvarez Bermúdez, María José; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (American Chemical Society, 2012)
      Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for “on demand” spatiotemporal control of their in vivo nucleic acid binding, as well as for ...
    • Influence of Multiple Conformations and Paths on Rate Constants and Product Branching Ratios. Thermal Decomposition of 1-Propanol Radicals 

      Ferro Costas, David; Martínez Núñez, Emilio; Rodríguez Otero, Jesús; Cabaleiro Lago, Enrique Manuel; Estévez, Carlos M.; Fernández Rodríguez, Berta; Fernández Ramos, Antonio; Vázquez Rodríguez, Saulo Angel (American Chemical Society, 2018-05-15)
      The potential energy surface involved in the thermal decomposition of 1-propanol radicals was investigated in detail using automated codes (tsscds2018 and Q2DTor). From the predicted elementary reactions, a relevant reaction ...
    • Infrared study of the magnetostructural phase transition in correlated CrN 

      Ebad-Allah, Jihaan; Kugelmann, B.; Rivadulla, Francisco; Kuntscher, Christine (APS Physics, 2016)
      We report on the pressure and temperature dependence of the electronic and vibrational properties of polycrystalline CrN studied by optical transmission and reflection measurements over the frequency range 0.012–2.48 eV. ...
    • Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies 

      González Bello, Concepción (Bentham Science, 2016)
      The loss of effectiveness of current antibiotics caused by the development of drug resistance has become a severe threat to public health. Current widely used antibiotics are surprisingly targeted at a few bacterial functions ...
    • Insights into substrate binding and catalysis in bacterial type I dehydroquinase 

      Maneiro Rey, María; Peón López, Antonio; Lence Quintana, Emilio José; Otero Casas, José Manuel; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Portland Press, 2014-09-15)
      Structural, biochemical and computational studies to study substrate binding and the role of the conserved residues of the DHQ1 (type I dehydroquinase) enzyme active site are reported in the present paper. The crystal ...
    • Integration of functional complex oxide nanomaterials on silicon 

      Vila-Fungueiriño, José M.; Bachelet, Romain; Saint-Girons, Guillaume; Gendry, Michael; Gich, Marti; Gazquez, Jaume; Ferain, Etienne; Rivadulla, Francisco; Rodríguez-Carvajal, Juan; Mestres, Narcis; Carretero-Genevrier, Adrián (Frontiers Media, 2015-06-09)
      The combination of standard wafer-scale semiconductor processing with the properties of functional oxides opens up to innovative and more efficient devices with high value applications which can be produced at large scale. ...
    • Interaction between angiotensin type 1, type 2, and mas receptors to regulate adult neurogenesis in the brain ventricular–subventricular zone 

      García Garrote, María; Pérez Villalba, Ana; Garrido Gil, Pablo; Belenguer, Germán; Parga Martín, Juan Andrés; Pérez Sánchez, Francisco; Labandeira García, José Luis; Fariñas, Isabel; Rodríguez Pallares, Jannette (MDPI, 2019)
      The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role ...
    • Interfacial tension measurements using a new axisymmetric drop/bubble shape technique 

      Cabrerizo Vílchez, Miguel Ángel; Fernández García, José Ramón; Fernández Rodríguez, Miguel Ángel; García Río, Luis; Muñiz Castiñeira, María del Carmen; Núñez García, Cristina (Royal Society of Chemistry, 2019)
      This paper introduces a new mathematical model that is used to compute either the interfacial tension of quiescent axisymmetric pendant/sessile drops and pendant/captive bubbles. This model consists of the Young–Laplace ...
    • Interferon induction by avian reovirus 

      Lostalé Seijo, Irene; Martínez Costas, José Manuel; Benavente Martínez, Francisco Javier (Elsevier, 2016-01)
      We have previously shown that the replication of avian reovirus (ARV) in chicken embryo fibroblasts (CEF) is more resistant to the antiviral action of interferon (IFN) than the replication of vesicular stomatitis virus ...
    • Intracellular Delivery of Biologically-Active Fungal Metabolite Gliotoxin Using Magnetic Nanoparticles 

      Comas, Laura; Polo Tobajas, Ester; Domingo, M. Pilar; Hernández, Yulán; Arias, Maykel; Esteban, Patricia; Martínez-Lostao, Luis; Pardo, Julián; Martínez de la Fuente, Jesús; Gálvez, Eva M. (MDPI, 2019)
      Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish ...
    • Intracellular deprotection reactions mediated by palladium complexes equipped with designed phosphine ligands 

      Martínez Calvo, Miguel; Rodríguez Couceiro, José; Destito, Paolo; Rodríguez Villar, Jéssica; Mosquera Mosquera, Jesús; Mascareñas Cid, José Luis (American Chemical Society, 2018-06-01)
      Discrete palladium(II) complexes featuring purposely designed phosphine ligands can promote depropargylation and deallylation reactions in cell lysates. These complexes perform better than other palladium sources, which ...
    • Intracellular Reactions Promoted by Bis(histidine) Miniproteins Stapled Using Palladium(II) Complexes 

      Learte Aymamí, Soraya; Vidal Vives, Christian; Gutiérrez González, Alejandro; Mascareñas Cid, José Luis (Wiley, 2020)
      The generation of catalytically active metalloproteins inside living mammalian cells is a major research challenge at the interface between catalysis and cell biology. Herein we demonstrate that basic domains of bZIP ...
    • Intracellular Ruthenium‐Promoted (2+2+2) Cycloadditions 

      Miguel Ávila, Joan; Tomás Gamasa, María; Mascareñas Cid, José Luis (Wiley, 2020)
      Metal‐mediated intracellular reactions are becoming invaluable tools in chemical and cell biology, and hold promise for strongly impacting the field of biomedicine. Most of the reactions reported so far involve either ...





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