Now showing items 143-162 of 361

    • Integration of functional complex oxide nanomaterials on silicon 

      Vila-Fungueiriño, José M.; Bachelet, Romain; Saint-Girons, Guillaume; Gendry, Michael; Gich, Marti; Gazquez, Jaume; Ferain, Etienne; Rivadulla, Francisco; Rodríguez-Carvajal, Juan; Mestres, Narcis; Carretero-Genevrier, Adrián (Frontiers Media, 2015-06-09)
      The combination of standard wafer-scale semiconductor processing with the properties of functional oxides opens up to innovative and more efficient devices with high value applications which can be produced at large scale. ...
    • Interaction between angiotensin type 1, type 2, and mas receptors to regulate adult neurogenesis in the brain ventricular–subventricular zone 

      García Garrote, María; Pérez Villalba, Ana; Garrido Gil, Pablo; Belenguer, Germán; Parga Martín, Juan Andrés; Pérez Sánchez, Francisco; Labandeira García, José Luis; Fariñas, Isabel; Rodríguez Pallares, Jannette (MDPI, 2019)
      The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role ...
    • Interfacial tension measurements using a new axisymmetric drop/bubble shape technique 

      Cabrerizo Vílchez, Miguel Ángel; Fernández García, José Ramón; Fernández Rodríguez, Miguel Ángel; García Río, Luis; Muñiz Castiñeira, María del Carmen; Núñez García, Cristina (Royal Society of Chemistry, 2019)
      This paper introduces a new mathematical model that is used to compute either the interfacial tension of quiescent axisymmetric pendant/sessile drops and pendant/captive bubbles. This model consists of the Young–Laplace ...
    • Interferon induction by avian reovirus 

      Lostalé Seijo, Irene; Martínez Costas, José Manuel; Benavente Martínez, Francisco Javier (Elsevier, 2016-01)
      We have previously shown that the replication of avian reovirus (ARV) in chicken embryo fibroblasts (CEF) is more resistant to the antiviral action of interferon (IFN) than the replication of vesicular stomatitis virus ...
    • Intracellular Delivery of Biologically-Active Fungal Metabolite Gliotoxin Using Magnetic Nanoparticles 

      Comas, Laura; Polo Tobajas, Ester; Domingo, M. Pilar; Hernández, Yulán; Arias, Maykel; Esteban, Patricia; Martínez-Lostao, Luis; Pardo, Julián; Martínez de la Fuente, Jesús; Gálvez, Eva M. (MDPI, 2019)
      Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish ...
    • Intracellular deprotection reactions mediated by palladium complexes equipped with designed phosphine ligands 

      Martínez Calvo, Miguel; Rodríguez Couceiro, José; Destito, Paolo; Rodríguez Villar, Jéssica; Mosquera Mosquera, Jesús; Mascareñas Cid, José Luis (American Chemical Society, 2018-06-01)
      Discrete palladium(II) complexes featuring purposely designed phosphine ligands can promote depropargylation and deallylation reactions in cell lysates. These complexes perform better than other palladium sources, which ...
    • Intracellular Reactions Promoted by Bis(histidine) Miniproteins Stapled Using Palladium(II) Complexes 

      Learte Aymamí, Soraya; Vidal Vives, Christian; Gutiérrez González, Alejandro; Mascareñas Cid, José Luis (Wiley, 2020)
      The generation of catalytically active metalloproteins inside living mammalian cells is a major research challenge at the interface between catalysis and cell biology. Herein we demonstrate that basic domains of bZIP ...
    • Intracellular Ruthenium‐Promoted (2+2+2) Cycloadditions 

      Miguel Ávila, Joan; Tomás Gamasa, María; Mascareñas Cid, José Luis (Wiley, 2020)
      Metal‐mediated intracellular reactions are becoming invaluable tools in chemical and cell biology, and hold promise for strongly impacting the field of biomedicine. Most of the reactions reported so far involve either ...
    • Intramolecular Coupling of Terminal Alkynes by Atom Manipulation 

      Albrecht, Florian; Rey Vieites, Dulce María; Fatayer, Shadi; Schulz, Fabian; Pérez Meirás, María Dolores; Peña Gil, Diego; Gross, Leo (Wiley, 2020)
      Glaser‐like coupling of terminal alkynes by thermal activation is extensively used in on‐surface chemistry. Here we demonstrate an intramolecular version of this reaction performed by atom manipulation. We used voltage ...
    • Investigating Possible Enzymatic Degradation on Polymer Shells around Inorganic Nanoparticles 

      Zhu, Lin; Pelaz García, Beatriz; Chakraborty, Indranath; Parak, Wolfgang J. (Universidade de Santiago de Compostela, 2019)
      Inorganic iron oxide nanoparticle cores as model systems for inorganic nanoparticles were coated with shells of amphiphilic polymers, to which organic fluorophores were linked with different conjugation chemistries, including ...
    • Iridium(I)-Catalyzed Intramolecular Cycloisomerization of Enynes: Scope and Mechanistic Course 

      Fernández Fernández, David; Rodrigues, Catarina A. B.; Calvelo, Martín; Gulías Costa, Moisés; Mascareñas Cid, José Luis; López García, Fernando (American Chemical Society, 2018-07-10)
      We report an Ir(I)-catalyzed cycloisomerization methodology that provides access to carbocyclic systems bearing exo-alkene moieties from alkynyl-equipped acyclic precursors. The method relies on the C–H activation of ...
    • Iridium(I)-Catalyzed Intramolecular Hydrocarbonation of Alkenes: Efficient Access to Cyclic Systems Bearing Quaternary Stereocenters 

      Fernández Fernández, David; Gulías Costa, Moisés; Mascareñas Cid, José Luis; López García, Fernando (Wiley, 2017-07-12)
      A catalytic, versatile and atom-economical C−H functionalization process that provides a wide variety of cyclic systems featuring methyl-substituted quaternary stereocenters is described. The method relies on the use of a ...
    • Irreversible covalent modification of type I dehydroquinase with a stable Schiff base 

      Tizón, Lorena; Maneiro Rey, María; Peón López, Antonio; Otero Casas, José Manuel; Lence Quintana, Emilio José; Poza, Sergio; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Royal Society of Chemistry, 2015)
      The irreversible inhibition of type I dehydroquinase (DHQ1), the third enzyme of the shikimic acid pathway, is investigated by structural, biochemical and computational studies. Two epoxides, which are mimetics of the ...
    • Iterative catalyst controlled diastereodivergent synthesis of polypropionates 

      Roke, Diedrik; Fañanás Mastral, Martín; Feringa, Ben L. (Royal Society of Chemistry, 2016-11-01)
      Polypropionate fragments are synthesized using a combination of a copper-catalyzed asymmetric allylic alkylation, ruthenium-catalyzed cross-metathesis and iridium-catalyzed asymmetric allylic etherification. The use of an ...
    • Kinetic Isotope Effects in Multipath VTST: Application to a Hydrogen Abstraction Reaction 

      Simón-Carballido, Luis; Alves, Tiago Vinicius; Dybala-Defratyka, Agnieszka; Fernández-Ramos, Antonio (American Chemical Society, 2016)
      In this work we apply multipath canonical variational transition state theory with small-tunneling corrections (MP-CVT/SCT) to the hydrogen abstraction reaction from ethanol by atomic hydrogen in aqueous solution at room ...
    • Kinetic Resolution of Allyltriflamides through a Pd-Catalyzed C–H Functionalization with Allenes: Asymmetric Assembly of Tetrahydropyridines 

      González González, José Manuel; Cendón Mariño, Borja; Mascareñas Cid, José Luis; Gulías Costa, Moisés (American Chemical Society, 2021)
      Enantioenriched, six-membered azacycles are essential structural motifs in many products of pharmaceutical or agrochemical interest. Here we report a simple and practical method for enantioselective assembly of ...
    • Kinetics of the Methanol Reaction with OH at Interstellar, Atmospheric, and Combustion Temperatures 

      Gao, Lu Gem; Zheng, Jingjing; Fernández-Ramos, Antonio; Truhlar, Donald G.; Xu, Xuefei (American Chemical Society, 2018-01-04)
      The OH radical is the most important radical in combustion and in the atmosphere, and methanol is a fuel and antifreeze additive, model biofuel, and trace atmospheric constituent. These reagents are also present in ...
    • Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity 

      González-Vera, Juan A.; Bouzada, David; Bouclier, Céline; Vázquez Sentís, Marco Eugenio; Morris, May C. (Royal Society of Chemistry, 2017)
      We describe a lanthanide biosensor that responds to CDK4 kinase activity in melanoma cell extracts through a significant and dose dependent increase in luminescence, thanks to sensitization of a DOTA[Tb3+] complex incorporated ...
    • Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos 

      Penas Tallón, Cristina; Sánchez López, Mateo Isidro; Guerra Varela, Jorge; Sánchez Piñón, Laura; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2016)
      We synthesized octa‐arginine conjugates of DNA‐binding agents (bisbenzamidine, acridine and Thiazole Orange) and demonstrated that their DNA binding and cell internalization can be inhibited by appending a (negatively ...
    • Linseed oil as a model system for surface enhanced Raman spectroscopy detection of degradation products in artworks 

      Gómez, Manuel; Reggio, Daniela; Lazzari, Massimo (Wiley, 2019)
      Early evidence of materials decay can provide diagnostic insights to conservators and scientists enhancing the overall knowledge on art materials. Limited knowledge is available on the long‐term behavior of synthetic and ...





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