Now showing items 156-175 of 425

    • Highly Enantioselective Cobalt‐Catalyzed (3+2) Cycloadditions of Alkynylidenecyclopropanes 

      Concepción Vicente, Eduardo da; Fernández, Israel; Mascareñas Cid, José Luis; López García, Fernando (Wiley, 2021)
      Low‐valent cobalt complexes equipped with chiral ligands can efficiently promote highly enantioselective (3+2) cycloadditions of alkyne‐tethered alkylidenecyclopropanes. The annulation allows to assemble bicyclic systems ...
    • Highly Enantioselective Iridium(I)-Catalyzed Hydrocarbonation of Alkenes: A Versatile Approach to Heterocyclic Systems Bearing Quaternary Stereocenters 

      Arribas Domingo, Andrés; Calvelo Souto, Martín; Fernández Fernández, David; Rodrigues, Catarina A. B.; Mascareñas Cid, José Luis; López García, Fernando (Wiley, 2021)
      We report a versatile, highly enantioselective intramolecular hydrocarbonation reaction that provides a direct access to heteropolycyclic systems bearing chiral quaternary carbon stereocenters. The method, which relies on ...
    • Hindered rotor tunneling splittings: an application of the two-dimensional non-separable method to benzyl alcohol and two of its fluorine derivatives 

      Alves, Tiago Vinicius; Simón-Carballido, Luis; Rei Ornellas, Fernando; Fernández-Ramos, Antonio (Royal Society of Chemistry, 2016-02-29)
      In this work we present a novel application of the two-dimensional non-separable (2D-NS) method to the calculation of torsional tunneling splittings in systems with two hindered internal rotors. This method could be ...
    • Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media 

      Destito, Paolo; Sousa Castillo, Ana; Rodríguez Couceiro, José; López García, Fernando; Correa Duarte, Miguel Ángel; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2019)
      We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media. These palladium-equipped ...
    • A hybrid thermoresponsive plasmonic nanogel designed for NIR-mediated chemotherapy 

      Bergueiro Álvarez, Julián; Glitscher, Emanuel A.; Calderón, Marcelo (Elsevier, 2022)
      Temperature-trigger chemotherapy is one of the state-of-the-art anti-tumoral strategies in nanomedicine. However, this strategy is in close relationship with the effect of the temperature in the tumor tissue. With high ...
    • Hydrazone-modulated peptides for efficient gene transfection 

      Louzao Pernas, Iria; García Fandiño, Rebeca; Montenegro García, Javier (Royal Society of Chemistry, 2017-02-22)
      Gene transfection continues to be a major challenge in chemistry, biology and materials sciences. New methodologies and recent breakthroughs have renewed the interest in the discovery and development of new tools for ...
    • Hydroxybenzoic acid derivatives as dual-target ligands: mitochondriotropic antioxidants and cholinesterase inhibitors 

      Oliveira, Catarina; Cagide, Fernando; Teixeira, José; Amorim, Ricardo; Sequeira, Lisa; Mesiti, Francesco; Silva, Tiago; Garrido, Jorge; Remião, Fernando; Vilar Varela, Santiago; Uriarte Villares, Eugenio; Oliveira, Paulo J.; Borges, Fernanda (Frontiers Media, 2018)
      Alzheimer's disease (AD) is a multifactorial age-related disease associated with oxidative stress (OS) and impaired cholinergic transmission. Accordingly, targeting mitochondrial OS and restoring cholinergic transmission ...
    • Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme 

      Maneiro Rey, María; Lence Quintana, Emilio José; Sanz Gaitero, Marta; Otero Casas, José Manuel; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Royal Society of Chemistry, 2019)
      Targeted irreversible inhibitors bearing electrophiles that become activated towards covalent bond formation upon binding to a specific protein/enzyme is an emerging area in drug discovery. Targeting lysine residues is ...
    • IC-Tagging methodology applied to the expression of viral glycoproteins and the difficult-to-express membrane-bound IGRP autoantigen 

      Barreiro Piñeiro, Natalia; Lostalé Seijo, Irene; Varela Calviño, Rubén; Benavente Martínez, Francisco Javier; Martínez Costas, José Manuel (Springer Nature, 2018)
      We have previously developed a methodology to produce protein microspheres (MS) that can be loaded with proteins of interest in living cells through their C or N-terminal tagging with the so-called IC-Tag. The IC-Tagging ...
    • Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition 

      Wang, Xuesong; Jespers, Willem; Prieto Díaz, Rubén; Majellaro, Maria; IJzerman, Adriaan P.; Van Westen, Gerard J.P.; Sotelo Pérez, Eddy; Heitman, Laura H.; Gutiérrez de Terán, Hugo (Nature Publishing Group, 2021)
      The four adenosine receptors (ARs) A1AR, A2AAR, A2BAR, and A3AR are G protein-coupled receptors (GPCRs) for which an exceptional amount of experimental and structural data is available. Still, limited success has been ...
    • In situ detection of the protein corona in complex environments 

      Carril, Mónica; Prado, Daniel; Pino, Pablo del; Carrillo Carrión, Carolina; Gallego, Marta; Parak, Wolfgang J. (Springer Nature, 2017)
      Colloidal nanoparticles (NPs) are a versatile potential platform for in vivo nanomedicine. Inside blood circulation, NPs may undergo drastic changes, such as by formation of a protein corona. The in vivo corona cannot be ...
    • In situ functionalized polymers for siRNA delivery 

      Martínez Costas, José Manuel; Fernández Trillo, Francisco; Montenegro García, Javier; Granja Guillán, Juan Ramón; Priegue Caamaño, Juan Manuel; Crisan, Daniel (WILEY-VCH Verlag GmbH, 2016-04-21)
      A new method is reported herein for screening the biological activity of functional polymers across a consistent degree of polymerization and in situ, that is, under aqueous conditions and without purification/isolation ...
    • In situ nanofabrication of hybrid PEG-dendritic–inorganic nanoparticles and preliminary evaluation of their biocompatibility 

      Sousa Hervés, Ana; Sánchez Espinel, Christian; Fahmi, Amir; González-Fernández, África; Fernández Megía, Eduardo (Royal Society of Chemistry, 2015)
      An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal ...
    • In vivo degeneration and the fate of inorganic nanoparticles 

      Feliu, Neus; Docter, Dominic; Heine, Markus; Pino, Pablo del; Ashraf, Sumaira; Kolosnjaj-Tabi, Jelena; Macchiarini, Paolo; Nielsen, Peter; Alloyeau, Damien; Gazeau, Florence; Stauber, Roland H.; Parak, Wolfgang J. (Royal Society of Chemistry, 2016)
      What happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver, superparamagnetic iron oxide, or fluorescent quantum dot NPs after they have been administrated to a living being? This review discusses ...
    • In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains 

      Sánchez López, Mateo Isidro; Martínez Costas, José Manuel; González García, Francisco; Álvarez Bermúdez, María José; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (American Chemical Society, 2012)
      Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for “on demand” spatiotemporal control of their in vivo nucleic acid binding, as well as for ...
    • Influence of Multiple Conformations and Paths on Rate Constants and Product Branching Ratios. Thermal Decomposition of 1-Propanol Radicals 

      Ferro Costas, David; Martínez Núñez, Emilio; Rodríguez Otero, Jesús; Cabaleiro Lago, Enrique Manuel; Estévez, Carlos M.; Fernández Rodríguez, Berta; Fernández Ramos, Antonio; Vázquez Rodríguez, Saulo Angel (American Chemical Society, 2018-05-15)
      The potential energy surface involved in the thermal decomposition of 1-propanol radicals was investigated in detail using automated codes (tsscds2018 and Q2DTor). From the predicted elementary reactions, a relevant reaction ...
    • Infrared study of the magnetostructural phase transition in correlated CrN 

      Ebad-Allah, Jihaan; Kugelmann, B.; Rivadulla, Francisco; Kuntscher, Christine (APS Physics, 2016)
      We report on the pressure and temperature dependence of the electronic and vibrational properties of polycrystalline CrN studied by optical transmission and reflection measurements over the frequency range 0.012–2.48 eV. ...
    • Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies 

      González Bello, Concepción (Bentham Science, 2016)
      The loss of effectiveness of current antibiotics caused by the development of drug resistance has become a severe threat to public health. Current widely used antibiotics are surprisingly targeted at a few bacterial functions ...
    • Insights into substrate binding and catalysis in bacterial type I dehydroquinase 

      Maneiro Rey, María; Peón López, Antonio; Lence Quintana, Emilio José; Otero Casas, José Manuel; Raaij, Mark J. van; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Portland Press, 2014-09-15)
      Structural, biochemical and computational studies to study substrate binding and the role of the conserved residues of the DHQ1 (type I dehydroquinase) enzyme active site are reported in the present paper. The crystal ...
    • Integration of functional complex oxide nanomaterials on silicon 

      Vila-Fungueiriño, José M.; Bachelet, Romain; Saint-Girons, Guillaume; Gendry, Michael; Gich, Marti; Gazquez, Jaume; Ferain, Etienne; Rivadulla, Francisco; Rodríguez-Carvajal, Juan; Mestres, Narcis; Carretero-Genevrier, Adrián (Frontiers Media, 2015-06-09)
      The combination of standard wafer-scale semiconductor processing with the properties of functional oxides opens up to innovative and more efficient devices with high value applications which can be produced at large scale. ...





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