Browsing CIQUS-Artigos by Title
Now showing items 162-181 of 408
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Insights into substrate binding and catalysis in bacterial type I dehydroquinase
(Portland Press, 2014-09-15)Structural, biochemical and computational studies to study substrate binding and the role of the conserved residues of the DHQ1 (type I dehydroquinase) enzyme active site are reported in the present paper. The crystal ... -
Integration of functional complex oxide nanomaterials on silicon
(Frontiers Media, 2015-06-09)The combination of standard wafer-scale semiconductor processing with the properties of functional oxides opens up to innovative and more efficient devices with high value applications which can be produced at large scale. ... -
Interaction between angiotensin type 1, type 2, and mas receptors to regulate adult neurogenesis in the brain ventricular–subventricular zone
(MDPI, 2019)The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role ... -
Interfacial tension measurements using a new axisymmetric drop/bubble shape technique
(Royal Society of Chemistry, 2019)This paper introduces a new mathematical model that is used to compute either the interfacial tension of quiescent axisymmetric pendant/sessile drops and pendant/captive bubbles. This model consists of the Young–Laplace ... -
Interferon induction by avian reovirus
(Elsevier, 2016-01)We have previously shown that the replication of avian reovirus (ARV) in chicken embryo fibroblasts (CEF) is more resistant to the antiviral action of interferon (IFN) than the replication of vesicular stomatitis virus ... -
Intracellular Delivery of Biologically-Active Fungal Metabolite Gliotoxin Using Magnetic Nanoparticles
(MDPI, 2019)Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish ... -
Intracellular deprotection reactions mediated by palladium complexes equipped with designed phosphine ligands
(American Chemical Society, 2018-06-01)Discrete palladium(II) complexes featuring purposely designed phosphine ligands can promote depropargylation and deallylation reactions in cell lysates. These complexes perform better than other palladium sources, which ... -
Intracellular Reactions Promoted by Bis(histidine) Miniproteins Stapled Using Palladium(II) Complexes
(Wiley, 2020)The generation of catalytically active metalloproteins inside living mammalian cells is a major research challenge at the interface between catalysis and cell biology. Herein we demonstrate that basic domains of bZIP ... -
Intracellular Ruthenium‐Promoted (2+2+2) Cycloadditions
(Wiley, 2020)Metal‐mediated intracellular reactions are becoming invaluable tools in chemical and cell biology, and hold promise for strongly impacting the field of biomedicine. Most of the reactions reported so far involve either ... -
Intramolecular Coupling of Terminal Alkynes by Atom Manipulation
(Wiley, 2020)Glaser‐like coupling of terminal alkynes by thermal activation is extensively used in on‐surface chemistry. Here we demonstrate an intramolecular version of this reaction performed by atom manipulation. We used voltage ... -
Investigating Possible Enzymatic Degradation on Polymer Shells around Inorganic Nanoparticles
(Universidade de Santiago de Compostela, 2019)Inorganic iron oxide nanoparticle cores as model systems for inorganic nanoparticles were coated with shells of amphiphilic polymers, to which organic fluorophores were linked with different conjugation chemistries, including ... -
Iridium(I)-Catalyzed Intramolecular Cycloisomerization of Enynes: Scope and Mechanistic Course
(American Chemical Society, 2018-07-10)We report an Ir(I)-catalyzed cycloisomerization methodology that provides access to carbocyclic systems bearing exo-alkene moieties from alkynyl-equipped acyclic precursors. The method relies on the C–H activation of ... -
Iridium(I)-Catalyzed Intramolecular Hydrocarbonation of Alkenes: Efficient Access to Cyclic Systems Bearing Quaternary Stereocenters
(Wiley, 2017-07-12)A catalytic, versatile and atom-economical C−H functionalization process that provides a wide variety of cyclic systems featuring methyl-substituted quaternary stereocenters is described. The method relies on the use of a ... -
Irreversible covalent modification of type I dehydroquinase with a stable Schiff base
(Royal Society of Chemistry, 2015)The irreversible inhibition of type I dehydroquinase (DHQ1), the third enzyme of the shikimic acid pathway, is investigated by structural, biochemical and computational studies. Two epoxides, which are mimetics of the ... -
Iterative catalyst controlled diastereodivergent synthesis of polypropionates
(Royal Society of Chemistry, 2016-11-01)Polypropionate fragments are synthesized using a combination of a copper-catalyzed asymmetric allylic alkylation, ruthenium-catalyzed cross-metathesis and iridium-catalyzed asymmetric allylic etherification. The use of an ... -
Kinetic Isotope Effects in Multipath VTST: Application to a Hydrogen Abstraction Reaction
(American Chemical Society, 2016)In this work we apply multipath canonical variational transition state theory with small-tunneling corrections (MP-CVT/SCT) to the hydrogen abstraction reaction from ethanol by atomic hydrogen in aqueous solution at room ... -
Kinetic Resolution of Allyltriflamides through a Pd-Catalyzed C–H Functionalization with Allenes: Asymmetric Assembly of Tetrahydropyridines
(American Chemical Society, 2021)Enantioenriched, six-membered azacycles are essential structural motifs in many products of pharmaceutical or agrochemical interest. Here we report a simple and practical method for enantioselective assembly of ... -
Kinetics of the Methanol Reaction with OH at Interstellar, Atmospheric, and Combustion Temperatures
(American Chemical Society, 2018-01-04)The OH radical is the most important radical in combustion and in the atmosphere, and methanol is a fuel and antifreeze additive, model biofuel, and trace atmospheric constituent. These reagents are also present in ... -
Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity
(Royal Society of Chemistry, 2017)We describe a lanthanide biosensor that responds to CDK4 kinase activity in melanoma cell extracts through a significant and dose dependent increase in luminescence, thanks to sensitization of a DOTA[Tb3+] complex incorporated ... -
Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos
(Wiley, 2016)We synthesized octa‐arginine conjugates of DNA‐binding agents (bisbenzamidine, acridine and Thiazole Orange) and demonstrated that their DNA binding and cell internalization can be inhibited by appending a (negatively ...