Now showing items 188-207 of 379

    • MitoBlue as a tool to analyze the mitochondria-lysosome communication 

      Sánchez López, Mateo Isidro; Vida, Yolanda; Pérez-Inestrosa, Ezequiel; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio; Sugiura, Ayumu; Martínez Costas, José Manuel (Springer Nature, 2020)
      MitoBlue is a fluorescent bisamidine that can be used to easily monitor the changes in mitochondrial degradation processes in different cells and cellular conditions. MitoBlue staining pattern is exceptional among mitochondrial ...
    • MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria 

      Sánchez López, Mateo Isidro; Martínez Costas, José Manuel; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (American Chemical Society, 2014)
      We report the discovery of a fluorogenic dye, N1,N3-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high ...
    • Moderately Strong Photoacid Dissociates in Alcohols with High Transient Concentration of the Proton-Transfer Contact Pair 

      Brenlla, Alfonso; Veiga Gutiérrez, Manoel; Ríos Rodríguez, M. Carmen; Rodríguez-Prieto, Flor; Mosquera González, Manuel; Pérez Lustres, José Luis (American Chemical Society, 2014)
      Proton transfer from strong photoacids to hydroxylic solvents is much under debate. Experimentally, the main issue stems from relaxation and diffusion processes that are concomitant with ultrafast proton transfer and blur ...
    • Molecular Plumbing to Bend Self-Assembling Peptide Nanotubes 

      Novelli, Federica; Vilela Picos, Marcos; Pazó Vicente, Antía; Amorín López, Manuel; Granja Guillán, Juan Ramón (Wiley, 2021)
      Light-induced molecular piping of cyclic peptide nanotubes to form bent tubular structures is described. The process is based on the [4+4] photocycloaddition of anthracene moieties, whose structural changes derived from ...
    • Monitoring the Formation of Amyloid Oligomers Using Photoluminescence Anisotropy 

      Jiang, Bo; Aliyan, Amir; Cook, Nathan P.; Augustine, Andrea; Bhak, Ghibom; Maldonado, Rodrigo; Smith McWilliams, Ashleigh D.; Flores, Erick M.; Mendez, Nicolas; Shahnawaz, Mohammad; Godoy, Fernando J.; Montenegro García, Javier; Moreno-Gonzalez, Ines; Martí, Angel A. (American Chemical Society, 2019-10)
      The formation of oligomeric soluble aggregates is related to the toxicity of amyloid peptides and proteins. In this manuscript, we report the use of a ruthenium polypyridyl complex ([Ru(bpy)2(dpqp)]2+) to track the formation ...
    • MSpin‐JCoupling. A modular program for prediction of scalar couplings and fast implementation of Karplus relationships 

      Navarro-Vázquez, Armando; Santamaría Fernández, Raquel; Sardina, F. Javier (Wiley, 2018-05-17)
      MSpin‐JCoupling is a modular program for the prediction of scalar couplings using a large variety of Karplus relationships. The program was specially designed for small molecule analysis and can be run in graphical or ...
    • Multidimensional Hamiltonian for tunneling with position-dependent mass 

      Fernández-Ramos, Antonio; Smedarchina, Zorka; Siebrand, Willem (APS Physics, 2014-09-15)
      A multidimensional Hamiltonian for tunneling is formulated, based on the mode with imaginary frequency of the transition state as a reaction coordinate. To prepare it for diagonalization, it is transformed into a lower-dimension ...
    • Multidisciplinary approach to the transfection of plasmid DNA by a nonviral nanocarrier based on a Gemini-Bolaamphiphilic hybrid lipid 

      Martínez Negro, María; Guerrero Martínez, Andrés; García Río, Luis; Domènech, Òscar; Aicart, Emilio; Tros de Ilarduya, Conchita; Junquera, Elena (American Chemical Society, 2018)
      A multidisciplinary strategy, including bothbiochemical and biophysical studies, was proposed here toevaluate the potential of lipid nanoaggregates consisting of amixture of a gemini−bolaamphiphilic lipid (C6C22C6) and ...
    • Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo 

      Pérez-Hernández, Marta; Moros, María; Stepien, Grazyna; Pino, Pablo del; Menao, Sebastián; Heras, Marcelo de las; Arias, Maykel; Mitchell, Scott G.; Pelaz García, Beatriz; Gálvez, Eva M.; Martínez de la Fuente, Jesús; Pardo, Julián (BioMed Central, 2017)
      Background The special physicochemical properties of gold nanoprisms make them very useful for biomedical applications including biosensing and cancer therapy. However, it is not clear how gold nanoprisms may affect ...
    • Multipodal dynamic coordination involving cation-π interactions to control the structure of helical polymers 

      Alzubi, Mohammad; Arias, Sandra; Louzao Pernas, Iria; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (Royal Society of Chemistry, 2017-07-06)
      A precise tuning of the four possible states of a helix (P/M helical sense and stretched/compressed helical backbone) is attained by controlling the complexation between Li+ and a poly(phenylacetylene) that bears amide, ...
    • Multistate Chiroptical Switch Triggered by Stimuli-Responsive Chiral Teleinduction 

      Rodríguez Riego, Rafael; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (American Chemical Society, 2018-04-11)
      Teleinduction of chirality, from a distant chiral center in the pendant, to the helical backbone of a poly(phenylacetylene) (PPA) was demonstrated by using an achiral, flexible and well-organized spacer originating a ...
    • Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover 

      Blanco Rodríguez, Beatriz; Prado, Verónica; Lence Quintana, Emilio José; Otero Casas, José Manuel; García Doval, Carmela; Raaij, Mark J. van; Llamas Saiz, Antonio Luis; Lamb, Heather; Hawkins, Alastair R.; González Bello, Concepción (American Chemical Society, 2013)
      Shikimate kinase (SK) is an essential enzyme in several pathogenic bacteria and does not have any counterpart in human cells, thus making it an attractive target for the development of new antibiotics. The key interactions ...
    • N-Doped Cationic PAHs by Rh(III)-Catalyzed Double C–H Activation and Annulation of 2-Arylbenzimidazoles with Alkynes 

      Villar Carabel, José Manuel; Suárez Rivero, Jaime; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (American Chemical Society, 2017)
      A novel class of N-doped cationic PAHs (Polycyclic Aromatic Hydrocarbons) bearing the benzo[c,d]fluoranthene scaffold has been synthesized by the Rh(III)-catalyzed double oxidative annulation of 2-arylbenzimidazoles with ...
    • Nanoparticles engineered to bind cellular motors for efficient delivery 

      Dalmau-Mena, Inmaculada; Pino, Pablo del; Pelaz García, Beatriz; Cuesta-Geijo, Miguel Ángel; Galindo, Inmaculada; Moros, María; Martínez de la Fuente, Jesús; Alonso, Covadonga (BioMed Central, 2018)
      Background Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as ...
    • Nanoscale metal–organic frameworks as key players in the context of drug delivery: evolution toward theranostic platforms 

      Carrillo Carrión, Carolina (Springer, 2020-01)
      Metal–organic frameworks (MOFs) have emerged as one of the most fascinating libraries of porous materials with a huge potential in very diverse application areas. In particular, the bioanalytical and biomedical fields have ...
    • A New Approach to the Synthesis of Benzo[b]naphtho[2,3-b]furan-6,11-diones and 2-Benzyl-3-hydroxynaphthalene-1,4-diones 

      Barcia Barcia, José Carlos; Cruces, Jacobo; Salas, Cristian O.; Estévez Cabanas, Juan Carlos; Cuéllar, Mauricio A.; Tapia, Ricardo A.; Estévez Cabanas, Ramón José (Georg Thieme Verlag, 2017)
      Here we describe modified syntheses of o-acetylbenzoic acids and o-acetylphenylacetic acids by Heck palladium-catalysed arylation of n-butyl vinyl ether with o-iodobenzoic acids or with o-iodophenylacetic acids, respectively. ...
    • New Approaches in Nanomedicine for Ischemic Stroke 

      Correa Paz, Clara; Silva Candal, Andrés da; Polo Tobajas, Ester; Parcq, Jerome; Vivien, Denis; Maysinger, Dusica; Pelaz García, Beatriz; Campos Pérez, Francisco (MDPI, 2021)
      Ischemic stroke, caused by the interruption of blood flow to the brain and subsequent neuronal death, represents one of the main causes of disability in developed countries. Therapeutic methods such as recanalization ...
    • New interpretation of proton and deuteron tunneling in 2'-methylacetophenone 

      Fernández-Ramos, Antonio; Siebrand, Willem; Smedarchina, Zorka (Elsevier, 2013-10-24)
      The enol–keto transition rate constants in 2′-methylacetophenone observed by Grellmann et al. are calculated from first principles. The results reinterpret the proposed mechanism and show that proton tunneling is preceded ...
    • A New Pathway for Protein Haptenation by β‐Lactams 

      Pérez Ruiz, Raúl; Lence Quintana, Emilio José; Andreu, Inmaculada; Limones Herrero, Daniel; González Bello, Concepción; Miranda, Miguel A.; Jiménez, Consuelo M. (Wiley, 2017-08-09)
      The covalent binding of β‐lactams to proteins upon photochemical activation has been demonstrated by using an integrated approach that combines photochemical, proteomic and computational studies, selecting human serum ...
    • A new potential nano-oncological therapy based on polyamino acid nanocapsules 

      Gonzalo, Teresa; Lollo, Giovanna; García-Fuentes, Marcos; Torres, Dolores; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Calvo, Pilar; Avilés, Pablo; Guillén, Maria José; Alonso Fernández, María José (Elsevier, 2013-07)
      A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ...





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