Now showing items 196-215 of 378

    • Multipodal dynamic coordination involving cation-π interactions to control the structure of helical polymers 

      Alzubi, Mohammad; Arias, Sandra; Louzao Pernas, Iria; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (Royal Society of Chemistry, 2017-07-06)
      A precise tuning of the four possible states of a helix (P/M helical sense and stretched/compressed helical backbone) is attained by controlling the complexation between Li+ and a poly(phenylacetylene) that bears amide, ...
    • Multistate Chiroptical Switch Triggered by Stimuli-Responsive Chiral Teleinduction 

      Rodríguez Riego, Rafael; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (American Chemical Society, 2018-04-11)
      Teleinduction of chirality, from a distant chiral center in the pendant, to the helical backbone of a poly(phenylacetylene) (PPA) was demonstrated by using an achiral, flexible and well-organized spacer originating a ...
    • Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover 

      Blanco Rodríguez, Beatriz; Prado, Verónica; Lence Quintana, Emilio José; Otero Casas, José Manuel; García Doval, Carmela; Raaij, Mark J. van; Llamas Saiz, Antonio Luis; Lamb, Heather; Hawkins, Alastair R.; González Bello, Concepción (American Chemical Society, 2013)
      Shikimate kinase (SK) is an essential enzyme in several pathogenic bacteria and does not have any counterpart in human cells, thus making it an attractive target for the development of new antibiotics. The key interactions ...
    • N-Doped Cationic PAHs by Rh(III)-Catalyzed Double C–H Activation and Annulation of 2-Arylbenzimidazoles with Alkynes 

      Villar Carabel, José Manuel; Suárez Rivero, Jaime; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (American Chemical Society, 2017)
      A novel class of N-doped cationic PAHs (Polycyclic Aromatic Hydrocarbons) bearing the benzo[c,d]fluoranthene scaffold has been synthesized by the Rh(III)-catalyzed double oxidative annulation of 2-arylbenzimidazoles with ...
    • Nanoparticles engineered to bind cellular motors for efficient delivery 

      Dalmau-Mena, Inmaculada; Pino, Pablo del; Pelaz García, Beatriz; Cuesta-Geijo, Miguel Ángel; Galindo, Inmaculada; Moros, María; Martínez de la Fuente, Jesús; Alonso, Covadonga (BioMed Central, 2018)
      Background Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as ...
    • Nanoscale metal–organic frameworks as key players in the context of drug delivery: evolution toward theranostic platforms 

      Carrillo Carrión, Carolina (Springer, 2020-01)
      Metal–organic frameworks (MOFs) have emerged as one of the most fascinating libraries of porous materials with a huge potential in very diverse application areas. In particular, the bioanalytical and biomedical fields have ...
    • A New Approach to the Synthesis of Benzo[b]naphtho[2,3-b]furan-6,11-diones and 2-Benzyl-3-hydroxynaphthalene-1,4-diones 

      Barcia Barcia, José Carlos; Cruces, Jacobo; Salas, Cristian O.; Estévez Cabanas, Juan Carlos; Cuéllar, Mauricio A.; Tapia, Ricardo A.; Estévez Cabanas, Ramón José (Georg Thieme Verlag, 2017)
      Here we describe modified syntheses of o-acetylbenzoic acids and o-acetylphenylacetic acids by Heck palladium-catalysed arylation of n-butyl vinyl ether with o-iodobenzoic acids or with o-iodophenylacetic acids, respectively. ...
    • New Approaches in Nanomedicine for Ischemic Stroke 

      Correa Paz, Clara; Silva Candal, Andrés da; Polo Tobajas, Ester; Parcq, Jerome; Vivien, Denis; Maysinger, Dusica; Pelaz García, Beatriz; Campos Pérez, Francisco (MDPI, 2021)
      Ischemic stroke, caused by the interruption of blood flow to the brain and subsequent neuronal death, represents one of the main causes of disability in developed countries. Therapeutic methods such as recanalization ...
    • New interpretation of proton and deuteron tunneling in 2'-methylacetophenone 

      Fernández-Ramos, Antonio; Siebrand, Willem; Smedarchina, Zorka (Elsevier, 2013-10-24)
      The enol–keto transition rate constants in 2′-methylacetophenone observed by Grellmann et al. are calculated from first principles. The results reinterpret the proposed mechanism and show that proton tunneling is preceded ...
    • A New Pathway for Protein Haptenation by β‐Lactams 

      Pérez Ruiz, Raúl; Lence Quintana, Emilio José; Andreu, Inmaculada; Limones Herrero, Daniel; González Bello, Concepción; Miranda, Miguel A.; Jiménez, Consuelo M. (Wiley, 2017-08-09)
      The covalent binding of β‐lactams to proteins upon photochemical activation has been demonstrated by using an integrated approach that combines photochemical, proteomic and computational studies, selecting human serum ...
    • A new potential nano-oncological therapy based on polyamino acid nanocapsules 

      Gonzalo, Teresa; Lollo, Giovanna; García-Fuentes, Marcos; Torres, Dolores; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Calvo, Pilar; Avilés, Pablo; Guillén, Maria José; Alonso Fernández, María José (Elsevier, 2013-07)
      A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ...
    • New self-assembling peptide nanotubes of large diameter using δ-amino acids 

      Lamas Pérez, Alejandro; Guerra Fandiño, Arcadio José; Amorín López, Manuel; Granja Guillán, Juan Ramón (Royal Society of Chemistry, 2018)
      Here we show that 4-aminocyclohexanecarboxylic acid is a rigid stretcher building block for the preparation of cyclic peptides that self-assemble to form peptide nanotubes with large diameter and hydrophobic pores. The ...
    • Nickel-Catalyzed Intramolecular [3 + 2 + 2] Cycloadditions of Alkylidenecyclopropanes. A Straightforward Entry to Fused 6,7,5- Tricyclic Systems 

      Saya Codesal, Lucía; Fernández, Israel; Mascareñas Cid, José Luis; López García, Fernando (American Chemical Society, 2014-09-18)
      A highly diastereo- and chemoselective intramolecular nickel-catalyzed cycloaddition of alkene- and alkyne-tethered alkynylidenecyclopropanes is reported. The method constitutes the first fully intramolecular [3 + 2 + 2] ...
    • Nickel-promoted recognition of long DNA sites by designed peptide derivatives 

      Rodríguez Villar, Jéssica; Mosquera Mosquera, Jesús; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (WILEY-VCH Verlag GmbH, 2016-08-03)
      We describe the synthesis of designed peptidic modules that self-assemble in specific DNA sequences of 12 base pairs in the presence of NiII salts. The modules consist of modified fragments of transcription factors that ...
    • Nonmonotonic evolution of the charge gap in ZnV2O4 under pressure 

      Kuntscher, Christine; Rabia, Kaneez; Forthaus, M.K.; Abd-Elmeguid, M. M.; Rivadulla, Francisco; Kato, Y.; Batista, Cristian D. (APS Physics, 2012)
      A2+V2O4 spinels provide a unique opportunity for studying the evolution of the charge gap of Mott insulators that approach the itinerant electron limit under the application of external pressure. Here we report ...
    • Nonplanar Tub-shaped Benzocyclooctatetraenes via Halogen-Radical Ring Opening of Dihydrobiphenylenes 

      Bello García, Jesús; Padín Santos, Damián; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (American Chemical Society, 2021)
      A novel tandem Ru-catalyzed [2 + 2 +2] cycloaddition of arylenynes to dihydrobiphenylenes followed by halogen-radical ring opening has been developed for the construction of tub-shaped halogenated benzocyclooctatetraenes ...
    • Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine 

      Coco, Laura del; Majellaro, María; Boccarelli, Angelina; Cellamare, Saverio; Altomare, Cosimo Damiano; Fanizzi, Francesco Paolo (MDPI, 2020)
      A 1H-NMR-based metabolomic study was performed on MCF-7 cell lines treated with a novel nicotinamide derivative (DT-8) in comparison with two drugs characterized by a well-established mechanism of action, namely the ...
    • Novel Supramolecular Nanoparticles Derived From Cucurbit[7]uril and Zwitterionic Surfactants 

      Fernández Rosas, Josefa; Pessêgo, Márcia Isabel Duarte; Acuña, Angel; Vazquez-Vazquez, Carlos; Montenegro García, Javier; Parajo, Mercedes; Rodriguez-Dafonte, Pedro; Nome, Faruk; García Río, Luis (American Chemistry Society, 2018-02-12)
      Binding constants, Log K ≈ 6.6 M-1, and NMR characterization of the complexes formed by sulfobetaines and cucurbit[7]uril (CB7) support the electrostatic interaction as major driving force. This very strong binding motif ...
    • Novel synthesis of platinum complexes and their intracellular delivery to tumor cells by means of magnetic nanoparticles 

      Quarta, Alessandra; Amorín López, Manuel; Aldegunde Rodríguez, María José; Blasi, Laura; Ragusa, Andrea; Nitti, Simone; Pugliese, Giammarino; Granja Guillán, Juan Ramón; Pellegrino, Teresa (Royal Society of Chemistry, 2019)
      Platinum-based drugs are popular in clinics as chemotherapeutic agents to treat solid tumors. However, severe side effects such as nephro- and neurotoxicity impose strict dosage limitations that can lead to the development ...
    • Nucleophilic Addition of Amines to Ruthenium Carbenes: ortho‐(Alkynyloxy)benzylamine Cyclizations towards 1,3‐Benzoxazines 

      González Rodríguez, Carlos; Suárez Álvarez, José Ramón; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (Wiley, 2015)
      A new ruthenium-catalyzed cyclization of ortho-(alkynyloxy)benzylamines to dihydro-1,3-benzoxazines is reported. The cyclization is thought to take place via the vinyl ruthenium carbene intermediates that are easily formed ...





      Harvesters:Useful links:
      Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contact Us | Send Feedback