Browsing CIQUS-Artigos by Title
Now showing items 203-222 of 364
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Nonmonotonic evolution of the charge gap in ZnV2O4 under pressure
(APS Physics, 2012)A2+V2O4 spinels provide a unique opportunity for studying the evolution of the charge gap of Mott insulators that approach the itinerant electron limit under the application of external pressure. Here we report ... -
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine
(MDPI, 2020)A 1H-NMR-based metabolomic study was performed on MCF-7 cell lines treated with a novel nicotinamide derivative (DT-8) in comparison with two drugs characterized by a well-established mechanism of action, namely the ... -
Novel Supramolecular Nanoparticles Derived From Cucurbit[7]uril and Zwitterionic Surfactants
(American Chemistry Society, 2018-02-12)Binding constants, Log K ≈ 6.6 M-1, and NMR characterization of the complexes formed by sulfobetaines and cucurbit[7]uril (CB7) support the electrostatic interaction as major driving force. This very strong binding motif ... -
Novel synthesis of platinum complexes and their intracellular delivery to tumor cells by means of magnetic nanoparticles
(Royal Society of Chemistry, 2019)Platinum-based drugs are popular in clinics as chemotherapeutic agents to treat solid tumors. However, severe side effects such as nephro- and neurotoxicity impose strict dosage limitations that can lead to the development ... -
Nucleophilic Addition of Amines to Ruthenium Carbenes: ortho‐(Alkynyloxy)benzylamine Cyclizations towards 1,3‐Benzoxazines
(Wiley, 2015)A new ruthenium-catalyzed cyclization of ortho-(alkynyloxy)benzylamines to dihydro-1,3-benzoxazines is reported. The cyclization is thought to take place via the vinyl ruthenium carbene intermediates that are easily formed ... -
Oligoalanine helical callipers for cell penetration
(Royal Society of Chemistry, 2018-05-23)Even for short peptides that are enriched in basic amino acids, the large chemical space that can be spanned by combinations of natural amino acids hinders the rational design of cell penetrating peptides. We here report ... -
A One-Step, Versatile Synthesis of Dibenzo [n.2.2] Macrobicyclic Compounds via a Conformation-Directed Macrocyclization Reaction
(American Chemical Society, 2013)A series of dibenzo [n.2.2] bicyclic compounds (n = 2–20) were prepared in one step and good yields starting from dimethyl anthracene-9,10-dicarboxylate. Reduction of the aromatic diester using lithium/naphthalene led to ... -
Orbital, charge, and spin couplings in Ru 25+O9 dimers of Ba3CoRu2O9
(APS Physics, 2012)e magnetic, transport, and structural properties of cold-pressed Ba3CoRu2O9 show (i) an antiferromagnetic transition, (ii) a semiconductor-semiconductor electronic transition where the resistivity is dominated by the ... -
Organometallic catalysis in biological media and living settings
(Elsevier, 2018-01-29)Organometallic catalysis has allowed the development of an impressive number of chemical transformations that could not be achieved using classical methodologies. Most of these reactions have been accomplished in organic ... -
Oxidation of Alkynes via Catalytic Metal-Vinylidenes
(Thieme, 2020)Metal-vinylidenes, generated by treatment of terminal alkynes with transition metals, are very useful intermediates in modern synthetic chemistry as shown by the high number of transformations in which they are involved. ... -
Oxygen vacancies in strained SrTiO 3 thin films: Formation enthalpy and manipulation
(APS Physics, 2017)We report the enthalpy of oxygen vacancy formation in thin films of electron-doped SrTiO 3 , under different degrees of epitaxial stress. We demonstrate that both compressive and tensile strain decrease this energy at ... -
Palladium(II)-Catalyzed annulation between ortho-alkenylphenols and allenes. Key role of the metal geometry in determining the reaction outcome
(American Chemical Society, 2016-04-14)2-Alkenylphenols react with allenes, upon treatment with catalytic amounts of Pd(II) and Cu(II), to give benzoxepine products in high yields and with very good regio- and diastereoselectivities. This contrasts with the ... -
Palladium-Catalyzed [5+2] Heteroannulation of Phenethylamides with 1,3-Dienes to Dopaminergic 3-Benzazepines
(American Chemical Society, 2020)Phenethyltriflamides react with 1,3-dienes upon treatment with a catalytic amount of Pd(OAc)2 and Cu(OAc)2/O2 as oxidant to afford chemo-, regio- and diastereoselectively 2,3,4,5-tetrahydro-1H-benzo[d]azepines (3-benzazepine ... -
Palladium-Catalyzed Conjugate Addition of Terminal Alkynes to Enones
(American Chemical Society, 2012)A practical protocol for the hydroalkynylation of enones using Pd catalysis is reported. The reaction proceeds efficiently with a variety of alkynes as well as with several cyclic and acyclic enones, providing synthetically ... -
Palladium-Catalyzed Formal (4+2) Cycloaddition between Alkyl Amides and Dienes Initiated by the Activation of C(sp3)−H Bonds
(American Chemical Society, 2020)We report a formal (4+2) cycloaddition between alkyl-nosylamides and dienes enabled by a palladium-catalyzed activation of C(sp3)–H bonds beta to the amide group. This atom economical reaction, which proceeds under ... -
Palladium-Catalyzed Formal (5 + 2) Annulation between ortho-Alkenylanilides and Allenes
(American Chemical Society, 2017-03-27)2-Alkenyltriflylanilides react with allenes upon treatment with catalytic amounts of Pd(OAc)2 and Cu(II) to give highly valuable 2,3-dihydro-1H-benzo[b]azepines, in good yields, and with very high regio- and diastereosel ... -
Palladium-Catalyzed, Enantioselective Formal Cycloaddition between Benzyltriflamides and Allenes: Straightforward Access to Enantioenriched Isoquinolines
(American Chemical Society, 2019)Benzyl and allyltriflamides can engage in Pd-catalyzed oxidative (4+2) annulations with allenes, to produce highly valuable tetrahydroisoquinoline or dihydropyridine skeletons. The reaction is especially efficient when ... -
Pd-Catalyzed (3 + 2) Heterocycloadditions between Alkylidenecyclopropanes and Carbonyls: Straightforward Assembly of Highly Substituted Tetrahydrofurans
(American Chemical Society, 2020)A Pd catalyst made from a Pd(0) source and a bulky biaryl phosphine ligand promotes highly efficient intramolecular (3 + 2) heterocycloadditions between alkylidenecyclopropanes (ACPs) and carbonyls. The annulations provide ... -
PEG-dendritic block copolymers for biomedical applications
(Royal Society of Chemistry, 2012)The incorporation of poly(ethylene glycol) (PEG) chains at the focal point of dendrimers results in customizable platforms where the careful selection of the PEG length, the nature of the peripheral groups, and the structure ... -
Peptide/Cas9 nanostructures for ribonucleoprotein cell membrane transport and gene edition
(Royal Society of Chemistry, 2017)The discovery of RNA guided endonucleases has emerged as one of the most important tools for gene edition and biotechnology. The selectivity and simplicity of the CRISPR/Cas9 strategy allows the straightforward targeting ...