Browsing CIQUS-Artigos by Title
Now showing items 203-222 of 379
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A New Approach to the Synthesis of Benzo[b]naphtho[2,3-b]furan-6,11-diones and 2-Benzyl-3-hydroxynaphthalene-1,4-diones
(Georg Thieme Verlag, 2017)Here we describe modified syntheses of o-acetylbenzoic acids and o-acetylphenylacetic acids by Heck palladium-catalysed arylation of n-butyl vinyl ether with o-iodobenzoic acids or with o-iodophenylacetic acids, respectively. ... -
New Approaches in Nanomedicine for Ischemic Stroke
(MDPI, 2021)Ischemic stroke, caused by the interruption of blood flow to the brain and subsequent neuronal death, represents one of the main causes of disability in developed countries. Therapeutic methods such as recanalization ... -
New interpretation of proton and deuteron tunneling in 2'-methylacetophenone
(Elsevier, 2013-10-24)The enol–keto transition rate constants in 2′-methylacetophenone observed by Grellmann et al. are calculated from first principles. The results reinterpret the proposed mechanism and show that proton tunneling is preceded ... -
A New Pathway for Protein Haptenation by β‐Lactams
(Wiley, 2017-08-09)The covalent binding of β‐lactams to proteins upon photochemical activation has been demonstrated by using an integrated approach that combines photochemical, proteomic and computational studies, selecting human serum ... -
A new potential nano-oncological therapy based on polyamino acid nanocapsules
(Elsevier, 2013-07)A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ... -
New self-assembling peptide nanotubes of large diameter using δ-amino acids
(Royal Society of Chemistry, 2018)Here we show that 4-aminocyclohexanecarboxylic acid is a rigid stretcher building block for the preparation of cyclic peptides that self-assemble to form peptide nanotubes with large diameter and hydrophobic pores. The ... -
Nickel-Catalyzed Intramolecular [3 + 2 + 2] Cycloadditions of Alkylidenecyclopropanes. A Straightforward Entry to Fused 6,7,5- Tricyclic Systems
(American Chemical Society, 2014-09-18)A highly diastereo- and chemoselective intramolecular nickel-catalyzed cycloaddition of alkene- and alkyne-tethered alkynylidenecyclopropanes is reported. The method constitutes the first fully intramolecular [3 + 2 + 2] ... -
Nickel-promoted recognition of long DNA sites by designed peptide derivatives
(WILEY-VCH Verlag GmbH, 2016-08-03)We describe the synthesis of designed peptidic modules that self-assemble in specific DNA sequences of 12 base pairs in the presence of NiII salts. The modules consist of modified fragments of transcription factors that ... -
Nonmonotonic evolution of the charge gap in ZnV2O4 under pressure
(APS Physics, 2012)A2+V2O4 spinels provide a unique opportunity for studying the evolution of the charge gap of Mott insulators that approach the itinerant electron limit under the application of external pressure. Here we report ... -
Nonplanar Tub-shaped Benzocyclooctatetraenes via Halogen-Radical Ring Opening of Dihydrobiphenylenes
(American Chemical Society, 2021)A novel tandem Ru-catalyzed [2 + 2 +2] cycloaddition of arylenynes to dihydrobiphenylenes followed by halogen-radical ring opening has been developed for the construction of tub-shaped halogenated benzocyclooctatetraenes ... -
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine
(MDPI, 2020)A 1H-NMR-based metabolomic study was performed on MCF-7 cell lines treated with a novel nicotinamide derivative (DT-8) in comparison with two drugs characterized by a well-established mechanism of action, namely the ... -
Novel Supramolecular Nanoparticles Derived From Cucurbit[7]uril and Zwitterionic Surfactants
(American Chemistry Society, 2018-02-12)Binding constants, Log K ≈ 6.6 M-1, and NMR characterization of the complexes formed by sulfobetaines and cucurbit[7]uril (CB7) support the electrostatic interaction as major driving force. This very strong binding motif ... -
Novel synthesis of platinum complexes and their intracellular delivery to tumor cells by means of magnetic nanoparticles
(Royal Society of Chemistry, 2019)Platinum-based drugs are popular in clinics as chemotherapeutic agents to treat solid tumors. However, severe side effects such as nephro- and neurotoxicity impose strict dosage limitations that can lead to the development ... -
Nucleophilic Addition of Amines to Ruthenium Carbenes: ortho‐(Alkynyloxy)benzylamine Cyclizations towards 1,3‐Benzoxazines
(Wiley, 2015)A new ruthenium-catalyzed cyclization of ortho-(alkynyloxy)benzylamines to dihydro-1,3-benzoxazines is reported. The cyclization is thought to take place via the vinyl ruthenium carbene intermediates that are easily formed ... -
Observation of nuclear-spin Seebeck effect
(Nature Publishing Group, 2021)Thermoelectric effects have been applied to power generators and temperature sensors that convert waste heat into electricity. The effects, however, have been limited to electrons to occur, and inevitably disappear at low ... -
Oligoalanine helical callipers for cell penetration
(Royal Society of Chemistry, 2018-05-23)Even for short peptides that are enriched in basic amino acids, the large chemical space that can be spanned by combinations of natural amino acids hinders the rational design of cell penetrating peptides. We here report ... -
A One-Step, Versatile Synthesis of Dibenzo [n.2.2] Macrobicyclic Compounds via a Conformation-Directed Macrocyclization Reaction
(American Chemical Society, 2013)A series of dibenzo [n.2.2] bicyclic compounds (n = 2–20) were prepared in one step and good yields starting from dimethyl anthracene-9,10-dicarboxylate. Reduction of the aromatic diester using lithium/naphthalene led to ... -
Orbital, charge, and spin couplings in Ru 25+O9 dimers of Ba3CoRu2O9
(APS Physics, 2012)e magnetic, transport, and structural properties of cold-pressed Ba3CoRu2O9 show (i) an antiferromagnetic transition, (ii) a semiconductor-semiconductor electronic transition where the resistivity is dominated by the ... -
Organometallic catalysis in biological media and living settings
(Elsevier, 2018-01-29)Organometallic catalysis has allowed the development of an impressive number of chemical transformations that could not be achieved using classical methodologies. Most of these reactions have been accomplished in organic ... -
Oxidation of Alkynes via Catalytic Metal-Vinylidenes
(Thieme, 2020)Metal-vinylidenes, generated by treatment of terminal alkynes with transition metals, are very useful intermediates in modern synthetic chemistry as shown by the high number of transformations in which they are involved. ...