Now showing items 276-295 of 378

    • Role of Microsolvation and Quantum Effects in the Accurate Prediction of Kinetic Isotope Effects: The Case of Hydrogen Atom Abstraction in Ethanol by Atomic Hydrogen in Aqueous Solution 

      Kannath, Suraj; Adamczyk, Paweł; Ferro Costas, David; Fernández Ramos, Antonio; Major, Dan Thomas; Dybała-Defratyka, Agnieszka (American Chemical Society, 2020)
      Hydrogen abstraction from ethanol by atomic hydrogen in aqueous solution is studied using two theoretical approaches: the multipath variational transition state theory (MP-VTST) and a path-integral formalism in combination ...
    • Ruthenation of Non‐stacked Guanines in DNA G‐Quadruplex Structures: Enhancement of c‐MYC Expression 

      Rodríguez Villar, Jéssica; Mosquera Mosquera, Jesús; Rodríguez Couceiro, José; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2016)
      Guanine quadruplexes (GQs) are compact four‐stranded DNA structures that play a key role in the control of a variety of biological processes, including gene transcription. Bulky ruthenium complexes featuring a bipyridine, ...
    • Ruthenium bipyridyl complexes as photocleavable dimerizers: deactivation of DNA-binding peptides using visible light 

      Mosquera Mosquera, Jesús; Sánchez López, Mateo Isidro; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2014-07-28)
      We report a photolabile biselectrophilic Ru(II) complex that can be used for homo- or heterodimerization of cysteine-containing peptides. The resulting dimers can be efficiently disassembled by long-wavelength light. As ...
    • Ruthenium-Catalyzed Azide–Thioalkyne Cycloadditions in Aqueous Media: A Mild, Orthogonal, and Biocompatible Chemical Ligation 

      Destito, Paolo; Rodríguez Couceiro, José; Faustino, Hélio; López García, Fernando; Mascareñas Cid, José Luis (Wiley, 2017-08-03)
      The development of efficient metal-promoted bioorthogonal ligations remains as a major scientific challenge. Demonstrated herein is that azides undergo efficient and regioselective room-temperature annulations with thioalkynes ...
    • Ruthenium-Catalyzed Oxidative Amidation of Alkynes to Amides 

      Álvarez Pérez, Andrea; Esteruelas Rodrigo, Miguel Ángel; Izquierdo, Susana; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (American Chemical Society, 2019)
      Complex CpRuCl(PPh3)2 catalyzes reactions of terminal alkynes with 4-picoline N-oxide and primary and secondary amines to afford the corresponding amides. The reactions occur in chlorinated solvent and aqueous medium, ...
    • Ruthenium-Catalyzed Redox Isomerizations inside Living Cells 

      Vidal Vides, Cristian; Tomás Gamasa, María; Gutiérrez González, Alejandro; Mascareñas Cid, José Luis (American Chemical Society, 2019)
      Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which ...
    • Ruthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H insertion. Synthesis of Benzofused Six-Membered Azaheterocycles 

      Padín Santos, Damián; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (American Chemical Society, 2020)
      Cp*RuCl-based catalyst enables the expedient access to a variety of benzofused six- membered azaheterocycles from unprotected o-alkynylanilines and trimethylsilyldiazomethane through an unprecedent tandem carbene/alkyne ...
    • Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras 

      Mosquera Mosquera, Jesús; Rodríguez Villar, Jéssica; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (WILEY-VCH Verlag GmbH, 2014-04-24)
      We report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor-groove DNA binders. The hybrid featuring the sequence of the native protein ...
    • Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides 

      Bouzada, David; Salvadó, Iria; Barka, Ghofrane; Rama, Gustavo; Martínez Costas, José Manuel; Lorca, Romina; Somoza, Álvaro; Melle-Franco, Manuel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2018)
      A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding ...
    • Self-Assembled Micro-Fibres by Oxime Connection of Linear Peptide Amphiphiles 

      Booth, Richard; Insua López, Ignacio; Bhak, Ghibom; Montenegro García, Javier (Royal Society of Chemistry, 2018)
      Linear peptide amphiphiles are excellent biocompatible scaffolds for the hierarchical self-assembly of one dimensional nanostructures in aqueous media. However, their structural exploration and screening of self-assembling ...
    • Self-assembling alfa,gamma-cyclic peptides that generate cavities with tunable properties 

      Rodríguez Vázquez, Nuria; García Fandiño, Rebeca; Amorín López, Manuel; Granja Guillán, Juan Ramón (Royal Society of Chemistry, 2016-01-01)
      The design and synthesis of β-sheet-based self-assembling cyclic peptides with tunable cavities is described. The incorporation of a γ-amino acid with a hydroxyl group at C2 allows the incorporation of different groups ...
    • Self-assembling molecular capsules based on alpha, gamma-Cyclic peptides 

      Ozores, Lionel Haxel; Amorín López, Manuel; Granja Guillán, Juan Ramón (American Chemical Society, 2016-12-20)
      A new capsule based on a β-sheet self-assembling cyclic peptide with the ability to recognize and release several guests is described. The host structure is composed of two self-complementary α,γ-cyclic peptides bearing a ...
    • Self-Assembly of Silver Metal Clusters of Small Atomicity on Cyclic Peptide Nanotubes 

      Cuerva, Miguel; García Fandiño, Rebeca; Vázquez Vázquez, Carlos; López Quintela, Manuel Arturo; Montenegro García, Javier; Granja Guillán, Juan Ramón (American Chemical Society, 2015-10-06)
      Subnanometric noble metal clusters, composed by only a few atoms, behave like molecular entities and display magnetic, luminescent and catalytic activities. However, non-covalent interactions of molecular metal clusters, ...
    • Self‐assembling Venturi‐like peptide nanotubes 

      Fuertes, Alberto; Ozores, Lionel Haxel; Amorín López, Manuel; Granja Guillán, Juan Ramón (Royal Society of Chemistry, 2017-01-14)
      We describe the design and synthesis of self-assembling peptide nanotubes that have an internal filter area and whose length and internal diameters, at the entrance and in the constricted area, are precisely controlled
    • Sequence Decoding of 1D to 2D Self-Assembling Cyclic Peptides 

      Díaz Arias, Sandra Natalia; Insua López, Ignacio; Bhak, Ghibom; Montenegro García, Javier (Wiley, 2020)
      The inherent ability of peptides to self-assemble with directional and rationally predictable interactions has fostered a plethora of synthetic two-dimensional (2D) supramolecular biomaterials. However, the design of ...
    • Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates 

      Mosquera Mosquera, Jesús; Sánchez López, Mateo Isidro; Valero, Julián; Mendoza, Javier de; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2015-02-18)
      Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to ...
    • Sequence‐Selective DNA Recognition with Peptide–Bisbenzamidine Conjugates 

      Sánchez López, Mateo Isidro; Vázquez Vázquez, Olalla; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2013)
      Transcription factors (TFs) are specialized proteins that play a key role in the regulation of genetic expression. Their mechanism of action involves the interaction with specific DNA sequences, which usually takes place ...
    • Sequence‐Specific DNA Recognition with Designed Peptides 

      Boga, Sonia; Bouzada, David; García Peña, Diego; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Wiley, 2018)
      Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only ...
    • Sequential Induction of Chirality in Helical Polymers: From the Stereocenter to the Achiral Solvent 

      Nieto-Ortega, Belén; Rodríguez Riego, Rafael; Medina, Samara; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Casado, Juan; Freire Iribarne, Félix Manuel; Ramírez, Francisco Javier (American Chemical Society, 2018-04-13)
      Several steps of chiral induction have been detected in poly(phenylacetylene)s among their different hierarchical levels of chirality by vibrational circular dichroism, namely, (i) from the stereogenic centers to the ...
    • Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery 

      Pazo Pascual, Marta; Salluce, Giulia; Lostalé Seijo, Irene; Juanes Carrasco, María Luisa; González García, Francisco; García Fandiño, Rebeca; Montenegro García, Javier (Royal Society of Chemistry, 2021)
      In this work we report a rational design strategy for the identification of new peptide prototypes for the non-disruptive supramolecular permeation of membranes and the transport of different macromolecular giant cargos. ...





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