Now showing items 316-335 of 408

    • Sequential Induction of Chirality in Helical Polymers: From the Stereocenter to the Achiral Solvent 

      Nieto-Ortega, Belén; Rodríguez Riego, Rafael; Medina, Samara; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Casado, Juan; Freire Iribarne, Félix Manuel; Ramírez, Francisco Javier (American Chemical Society, 2018-04-13)
      Several steps of chiral induction have been detected in poly(phenylacetylene)s among their different hierarchical levels of chirality by vibrational circular dichroism, namely, (i) from the stereogenic centers to the ...
    • Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery 

      Pazo Pascual, Marta; Salluce, Giulia; Lostalé Seijo, Irene; Juanes Carrasco, María Luisa; González García, Francisco; García Fandiño, Rebeca; Montenegro García, Javier (Royal Society of Chemistry, 2021)
      In this work we report a rational design strategy for the identification of new peptide prototypes for the non-disruptive supramolecular permeation of membranes and the transport of different macromolecular giant cargos. ...
    • Simple approximation for aggregation number determination by isothermal titration calorimetry: STAND-ITC 

      Fernández Garrido, Pablo; Rodriguez-Dafonte, Pedro; García Río, Luis; Piñeiro Guillén, Ángel (ACS Publications, 2021)
      A new proposal to obtain aggregation numbers from isothermal titration calorimetry dilution experiments is described and tested using dodecyl trimethyl ammonium bromide, dodecyl methylimidazolium chloride, dodecyl ...
    • Simultaneous Adjustment of Size and Helical Sense of Chiral Nanospheres and Nanotubes Derived from Axially Racemic Poly(phenyl acetylene)s 

      Arias, Sandra; Núñez Martínez, Manuel; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (Wiley, 2016-10-19)
      Nanospheres and nanotubes with full control of their size and helical sense are obtained in chloroform from the axially racemic chiral poly(phenylacetylene) poly-(R)-1 using either Ag+ as both chiral inducer and cross-linking ...
    • A Single Mutation is Sufficient to Modify the Metal Selectivity and Specificity of a Eukaryotic Manganese Superoxide Dismutase to Encompass Iron 

      Hunter, Thérèse; Bonetta, Rosalin; Sacco, Anthony; Vella, Marita; Sultana, Paul-Michael; Trinh, Chi H.; Fadia, Hava B. R.; Borowski, Tomasz; García Fandiño, Rebeca; Stockner, Thomas; Hunter, Gary J. (Wiley, 2018)
      We have generated a site‐directed mutant of the manganese superoxide dismutase SOD‐3 of C.elegans (MnSOD‐3) which modifies the metal specificity of the enzyme. While wild‐type MnSOD‐3 functions with manganese in the active ...
    • Single spin localization and manipulation in graphene open-shell nanostructures 

      Li, Jingcheng; Sanz, Sofia; Choi, Deung Jang; Corso, Martina; Peña Gil, Diego; Frederiksen, Thomas; Pascual, Jose Ignacio (Nature publishing group, 2019)
      Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion ...
    • Single‐Molecule Approach to DNA Minor‐Groove Association Dynamics 

      Bordello Malde, Jorge; Sánchez López, Mateo Isidro; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis; Al-Soufi, Wajih; Novo Rodríguez, María de la Merced (Wiley, 2012)
      Getting in the groove: Fluorescence correlation spectroscopy reveals that the dynamics of the association process of the bisbenzamidine minor‐groove binder BBA‐OG (blue with green star, see scheme) to dsDNA is not controlled ...
    • Site-selective reversible Diels–Alder reaction between a biphenylene-based polyarene and a semiconductor surface 

      Godlewski, Szymon; Engelund, Mads; Peña Gil, Diego; Zuzak, Rafał; Kawai, Hiroyo; Kolmer, Marek; Caeiro Rodríguez, Jorge; Guitián Rivera, Enrique; Vollhardt, K. Peter C.; Sánchez-Portal, Daniel; Szymonski, Marek; Pérez Meirás, María Dolores (Royal Society of Chemistry, 2018-04-28)
      Understanding the mechanisms involved in the covalent attachment of organic molecules to surfaces is a major challenge for nanotechnology and surface science. On the basis of classical organic chemistry mechanistic ...
    • Skeletal diversity in Pt- and Au-catalyzed annulations of allenedienes: dissecting unconventional mechanistic pathways 

      Nelson, Ronald; Calvelo Souto, Martín; García Fandiño, Rebeca; Lledós, Agustí; Ujaque, Gregori; Mascareñas Cid, José Luis; López García, Fernando (Royal Society of Chemistry, 2020)
      We describe the discovery of unprecedented annulation processes of 1,7-allenedienes, promoted by Pt or Au catalysts. These transformations revealed mechanistic pathways that had not been previously observed in reactions ...
    • Some Guidelines for the Synthesis and Melting Characterization of Azide Poly(ethylene glycol) Derivatives 

      González Fernández, Daniel; Torneiro Abuín, Mercedes; Lazzari, Massimo (MDPI, 2020)
      We provide fundamental guidelines in the form of a tutorial to be taken into account for the preparation and characterization of a specific class of poly(ethylene glycol) (PEG) derivatives, namely azide-terminated PEGs. ...
    • Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics 

      Méndez Ardoy, Alejandro; Bayón Fernández, Alfonso; Yu, Ziyi; Abell, Chris; Granja Guillán, Juan Ramón; Montenegro García, Javier (Wiley, 2020)
      The recent advances in the supramolecular polymerization of synthetic building blocks in aqueous conditions has given rise to new artificial and biocompatible functional materials. However, despite the importance of spatially ...
    • Specific chemical modification of bacterial type I dehydroquinase – opportunities for drug discovery 

      González Bello, Concepción (Future Science, 2015-11-24)
      Type I dehydroquinase (DHQ1) is a class I aldolase enzyme that catalyzes the reversible dehydration of 3-dehydroquinic acid to form 3-dehydroshikimic acid by multistep mechanism that involves the formation of Schiff-base ...
    • Spectroscopic characterization of mitochondrial G-quadruplexes 

      Illodo, Sara; Pérez González, Cibrán; Barcia, Ramiro; Rodriguez-Prieto, Flor ; Al-Soufi, Wajih; Novo Rodríguez, Mercedes (MDPI, 2022)
      Guanine quadruplexes (G4s) are highly polymorphic four-stranded structures formed within guanine-rich DNA and RNA sequences that play a crucial role in biological processes. The recent discovery of the first G4 structures ...
    • Stabilizing Edge Fluorination in Graphene Nanoribbons 

      Panighel, Mirco; Quiroga Fernández, Sabela; Brandimarte, Pedro; Moreno, Cesar; García Lekue, Aran; Vilas Varela, Manuel; Rey Vieites, Dulce María; Sauthier, Guillaume; Ceballos, Gustavo; Peña Gil, Diego; Mugarza, Aitor (American Chemical Society, 2020)
      The on-surface synthesis of edge-functionalized graphene nanoribbons (GNRs) is challenged by the stability of the functional groups throughout the thermal reaction steps of the synthetic pathway. Edge fluorination is a ...
    • Stepwise Filtering of the Internal Layers of Dendrimers by Transverse-Relaxation-Edited NMR 

      Pinto, Luiz F.; Riguera Vega, Ricardo; Fernández Megía, Eduardo (American Chemical Society, 2013)
      The characteristic distribution of transverse relaxation times (T2) within dendrimers (shorter values at the core than the periphery) can be exploited in T2-edited 1D and 2D NMR experiments for the stepwise filtering of ...
    • Stereoselective Formation of Chiral Metallopeptides 

      Rama, Gustavo; Ardá, Ana; Maréchal, Jean-Didier; Gamba, Ilaria; Ishida, Hitoshi; Jiménez Barbero, Jesús; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Wiley, 2012-05-03)
      Playing into our hands: The achiral bipyridine amino acid fluorenylmethyloxycarbonyl 5‐amino‐3‐oxapentanoic acid (Fmoc‐O1PenBpy‐OH) has been used for the solid‐phase synthesis of metallopeptides. Circular dichroism, molecular ...
    • Stereoselective self-assembly of DNA binding helicates directed by the Viral β-Annulus Trimeric Peptide Motif 

      Gómez González, Jacobo; Bouzada Reboredo, David; Pérez Márquez, Lidia Ana; Sciortino, Giuseppe; Maréchal, Jean-Didier; Vázquez López, Miguel; Vázquez Sentis, Marco Eugenio (ACS Publications, 2021)
      Combining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the ...
    • Stereoselective Synthesis of Highly Substituted 1,3-Dienes via “à la carte” Multifunctionalization of Borylated Dendralenes 

      Rivera Chao, Eva; Fañanás Mastral, Martín (Wiley, 2021)
      Despite the high relevance of 1,3-dienes, stereoselective methods to access tetrasubstituted conjugated dienes are still scarce. We here report an efficient and modular approach that provides access to multifunctional ...
    • Stimuli-Responsive DNA Binding by Synthetic Systems 

      Rodríguez Villar, Jéssica; Mosquera Mosquera, Jesús; Learte Aymamí, Soraya; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (American Chemical Society, 2020)
      Conspectus: DNA is the molecule responsible for the storage and transmission of the genetic information in living organisms. The expression of this information is highly regulated. In eukaryotes, it is achieved mainly at ...
    • Stimuli-responsive selection of target DNA sequences by synthetic bZIP peptides 

      Mosquera Mosquera, Jesús; Jiménez Balsa, Adrián; Dodero, Verónica Isabel; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Nature Publishing Group, 2013)
      One of the strategies used by nature to regulate gene expression relies on the stimulicontrolled combination of DNA-binding proteins. This in turn determines the target-binding site within the genome, and thereby whether ...





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