Now showing items 321-340 of 378

    • Studying an antiaromatic polycyclic hydrocarbon adsorbed on different surfaces 

      Mjazik, Zsolt; Pavliček, Niko; Vilas-Varela, Manuel; Pérez Meirás, María Dolores; Moll, Nikolaj; Guitián Rivera, Enrique; Meyer, Gehrard; Peña Gil, Diego; Gross, Leo (Springer Nature, 2018-03-22)
      Antiaromatic and open-shell molecules are attractive because of their distinct electronic and magnetic behaviour. However, their increased reactivity creates a challenge for probing their properties. Here, we describe the ...
    • Sub-µL measurements of the thermal conductivity and heat capacity of liquids 

      López Bueno, Carlos; Bugallo Ferrón, David; Leborán Alvarez, Víctor; Rivadulla Fernández, José Francisco (Royal Society of Chemistry, 2018)
      We present the analysis of the thermal conductivity, κ, and heat capacity, Cp, of a wide variety of liquids, covering organic molecular solvents, ionic liquids and water–polymer mixtures. These data were obtained from ≈0.6 ...
    • Supramolecular caging for cytosolic delivery of anionic probes 

      Fernández Caro, Héctor; Lostalé Seijo, Irene; Martínez Calvo, Miguel; Mosquera Mosquera, Jesús; Mascareñas Cid, José Luis; Montenegro García, Javier (Royal Society of Chemistry, 2019)
      The cytosolic delivery of hydrophilic, anionic molecular probes and therapeutics is a major challenge in chemical biology and medicine. Herein, we describe the design and synthesis of peptide–cage hybrids that allow an ...
    • Supramolecular functional assemblies: dynamic membrane transporters and peptide nanotubular composites 

      Fuertes García, Alberto; Juanes Carrasco, Marisa; Granja Guillán, Juan Ramón; Montenegro García, Javier (Royal Society of Chemistry, 2017-06-09)
      The fabrication of functional molecular devices constitutes one of the most important current challenges for chemical sciences. The complex processes accomplished by living systems continuously demand the assistance of ...
    • Supramolecular Recognition and Selective Protein Uptake by Peptide Hybrids 

      Juanes Carrasco, Marisa; Lostalé Seijo, Irene; Granja Guillán, Juan Ramón; Montenegro García, Javier (Wiley, 2018-04-27)
      The intracellular transport of exogenous proteins has emerged as one of the most promising methodologies for biotechnology and chemical biology. Current protein delivery is mainly approached by liposome encapsulation, ...
    • Surface enhanced Raman scattering (SERS) in the visible range on scalable aluminum-coated platforms 

      Gómez, Manuel; Kadkhodazadeh, Shima; Lazzari, Massimo (Royal Society of Chemistry, 2018-09-04)
      We demonstrate the potential of combining plasmonic Bragg grating structures, with the scattering effect of a rough Al layer to tune SERS enhancement in the visible region. Novel Al-based substrates with good analytical ...
    • Surface-Enhanced Raman Scattering Detection of Nucleic Acids Exhibiting Sterically Accessible Guanines Using Ruthenium-Polypyridyl Reagents 

      Martínez Calvo, Miguel; Guerrini, Luca; Rodríguez Villar, Jéssica; Álvarez Puebla, Ramón A.; Mascareñas Cid, José Luis (American Chemical Society, 2020)
      Here, we report the application of surface-enhanced Raman scattering (SERS) spectroscopy as a rapid and practical tool for assessing the formation of coordinative adducts between nucleic acid guanines and ruthenium polypyridyl ...
    • Surface-enhanced raman scattering surface selection rules for the proteomic liquid biopsy in real samples: Efficient detection of the oncoprotein c-MYC 

      Pazos Chantrero, Elena; García-Algar, Manuel; Penas Tallón, Cristina; Nazarenus, Moritz; Torruella, Arnau; Pazos-Pérez, Nicolás; Guerrini, Luca; Vázquez Sentís, Marco Eugenio; García-Rico, Eduardo; Mascareñas Cid, José Luis; Álvarez-Puebla, Ramón A. (American Chemical Society, 2016-10-12)
      Blood-based biomarkers (liquid biopsy) offer extremely valuable tools for the noninvasive diagnosis and monitoring of tumors. The protein c-MYC, a transcription factor that has been shown to be deregulated in up to 70% of ...
    • Survival of spin state in magnetic porphyrins contacted by graphene nanoribbons 

      Li, Jingcheng; Merino Díez, Nestor; Carbonell Sanromà, Eduard; Vilas Varela, Manuel; Oteyza, Dimas G. de; Peña Gil, Diego; Corso, Martina; Pascual, Jose Ignacio (American Association for the Advancement of Science (AAAS), 2018)
      We report on the construction and magnetic characterization of a fully functional hybrid molecular system composed of a single magnetic porphyrin molecule bonded to graphene nanoribbons with atomically precise contacts. ...
    • Synergistic Copper/Palladium Catalysis for the Regio- and Stereoselective Synthesis of Borylated Skipped Dienes 

      Mateos, Jaime; Rivera Chao, Eva; Fañanás-Mastral, Martín (American Chemical Society, 2017-07-12)
      A Cu/Pd-catalyzed allylboration of alkynes with allyl carbonates and bis(pinacolato)diboron to afford borylated skipped dienes is reported. Synergistic Cu and Pd catalysis enables this protocol to work for a wide array of ...
    • Synergistic gold and enamine catalysis: intermolecular α-alkylation of aldehydes with allenamides 

      Fernández Casado, Jaime; Nelson, Ronald; Mascareñas Cid, José Luis; López García, Fernando (Royal Society of Chemistry, 2016-01-08)
      Aldehydes can be α-alkylated with allenamides by the combined action of an organocatalyst and a gold complex. The reaction requires the simultaneous generation of an enamine and a gold-activated allenamide. Importantly, ...
    • Synthesis and characterization of a new bivalent ligand combining caffeine and docosahexaenoic acid 

      Fernández Dueñas, Víctor; Azuaje Guerrero, Jhonny Alberto; Morató, Xavier; Cordobilla, Begoña; Domingo, Joan Carles; Sotelo Pérez, Eddy; Ciruela, Francisco (MDPI, 2017)
      Caffeine is a promising drug for the management of neurodegenerative diseases such as Parkinson’s disease (PD), demonstrating neuroprotective properties that have been attributed to its interaction with the basal ganglia ...
    • Synthesis and Gelling Abilities of Polyfunctional Cyclohexane-1,2-dicarboxylic Acid Bisamides: Influence of the Hydroxyl Groups 

      Pi-Boleda, Bernat; Campos Torrado, María; Sans, Marta; Basavilbaso González, Antonio; Illa, Ona; Branchadell, Vicenç; Estévez Cabanas, Juan Carlos; Ortuño, Rosa M. (MDPI, 2019)
      New enantiomerically pure C16-alkyl diamides derived from trihydroxy cyclohexane-1,2-dicarboxylic acid have been synthesized from (−)-shikimic acid. The hydroxyl groups in these compounds are free or, alternatively, they ...
    • Synthesis and reactivity of a trigonal porous nanographene on a gold surface 

      Zuzak, Rafał; Pozo Míguez, Iago; Engelund, Mads; García Lekue, Aran; Vilas Varela, Manuel; Alonso, José M.; Szymonski, Marek; Guitián Rivera, Enrique Carlos; Pérez Meirás, María Dolores; Godlewski, Szymon; Peña Gil, Diego (Royal Society of Chemistry, 2019)
      The synthesis of porous nanographenes is a challenging task for solution chemistry, and thus, on-surface synthesis provides an alternative approach. Here, we report the synthesis of a triporous nanographene with 102 sp2 ...
    • Synthesis and Supramolecular Functional Assemblies of Ratiometric pH Probes 

      Méndez Ardoy, Alejandro; Reina Martín, Jose Juan; Montenegro García, Javier (Wiley, 2020)
      Tracking the pH with spatiotemporal resolution is a critical challenge for synthetic chemistry, chemical biology and beyond. Over the last decade different small probes and supramolecular systems have emerged for in celluloor ...
    • Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: factors influencing their inhibition potency 

      Blanco Rodríguez, Beatriz; Sedes, Antía; Peón López, Antonio; Lamb, Heather; Hawkins, Alastair R.; Castedo Expósito, José Luis; González Bello, Concepción (Royal Society of Chemistry, 2012-03-05)
      Several 3-alkylaryl mimics of the enol intermediate in the reaction catalyzed by type II dehydroquinase were synthesized to investigate the effect on the inhibition potency of replacing the oxygen atom in the side chain ...
    • Synthesis of rigidified shikimic acid derivatives by ring-closing metathesis to imprint inhibitor efficacy against shikimate kinase enzyme 

      Pernas Marín, Marina; Blanco Rodríguez, Beatriz; Lence Quintana, Emilio José; Thompson, Paul; Hawkins, Alastair R.; González Bello, Concepción (Royal Society of Chemistry, 2019)
      Diverse rigidified shikimic acids derivatives, which are stable mimetics of the high-energy conformation of shikimic acid, have been synthesized to enhance inhibitor efficacy against shikimate kinase enzyme (SK), an ...
    • Synthetic materials at the forefront of gene delivery 

      Lostalé Seijo, Irene; Montenegro García, Javier (Springer Nature, 2018-09-21)
      The delivery of nucleic acids with transient activity for genetic engineering is a promising methodology with potential applications in the treatment of diseases ranging from cancer and infectious diseases to heritable ...
    • Synthetic peptides caged on histidine residues with a bisbipyridyl ruthenium(II) complex that can be photolyzed by visible light 

      Mosquera Mosquera, Jesús; Sánchez López, Mateo Isidro; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (Royal Society of Chemistry, 2015-01-08)
      We report a light-sensitive histidine building block for Fmoc/tBu solid-phase peptide synthesis in which the imidazole side chain is coordinated to a ruthenium complex. We have applied this building block for the synthesis ...
    • Synthetic Supramolecular Systems in Life-like Materials and Protocell Models 

      Insua López, Ignacio; Montenegro García, Javier (Elsevier, 2020)
      One of the biggest challenges in modern chemistry is the preparation of synthetic materials with life-like behavior for the assembly of artificial cells. In recent years, numerous artificial systems that mimic cellular ...





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