Now showing items 26-45 of 358

    • A bio-inspired hypoxia sensor using HIF1a-oxygen-dependent degradation domain 

      Iglesias, Pablo; Penas Tallón, Cristina; Barral Cagiao, Laura; Pazos Chantrero, Elena; Costoya Puente, José Antonio (Nature Publishing Group, 2019)
      Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. ...
    • Biodegradable PEG–dendritic block copolymers: synthesis and biofunctionality assessment as vectors of siRNA 

      Leiro, Victoria; Garcia, João Pedro; Moreno, Pedro M. D.; Spencer, Ana Patrícia; Fernández Villamarín, Marcos; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Pêgo, Ana Paula (Royal Society of Chemistry, 2017-07-07)
      One important drawback of most of the currently used dendrimers for biomedical applications is their high stability under physiological conditions that can result in cytotoxicity or complications induced by the accumulation ...
    • A C60-aryne building block: synthesis of a hybrid all-carbon nanostructure 

      García, D.; Rodríguez-Pérez, L.; Herranz, M.A.; Peña Gil, Diego; Guitián Rivera, Enrique; Bailey, S.; Al-Galiby, Q.; Noori, M.; Lambert, C. J.; Pérez Meirás, María Dolores; Martín, N. (Royal Society of Chemistry, 2016-04-19)
      The synthesis of a [60]fullerene-benzyne building block and its further chemical cycloaddition reaction with graphene has resulted in a new all-carbon hybrid material which has been characterized by TGA, FTIR and Raman ...
    • [C^N]‐Alkenyl Gold(III) Complexes by Proximal Ring‐Opening of (2‐Pyridyl)alkylidenecyclopropanes: Mechanistic Insights 

      González, Jorge A.; Verdugo Leal, Felipe Ignacio; Mascareñas Cid, José Luis; López García, Fernando; Nevado, Cristina (Wiley, 2020)
      Pyridine‐substituted alkylidenecyclopropanes (Py‐ACPs) react with gold(III) salts under mild reaction conditions through an unprecedented, proximal ring‐opening pathway, to generate highly appealing, catalytically active ...
    • Calculation of the two-dimensional non-separable partition function for two molecular systems 

      Simón-Carballido, Luis; Fernández-Ramos, Antonio (Springer, 2014-04-02)
      We present the application of an accurate quantum treatment, called two-dimensional non-separable (2D-NS), to the calculation of internal rotation partition functions of molecules with two rotors. This methodology involves ...
    • Canonical DNA minor groove insertion of bisbenzamidine–Ru(ii) complexes with chiral selectivity 

      Sánchez, Mateo I.; Rama, Gustavo; Calo Lapido, Renata; Ucar, Kübra; Lincoln, Per; Vázquez López, Miguel; Melle-Franco, Manuel; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (Royal Society of Chemistry, 2019)
      We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor ...
    • Catalytic addition of C–H bonds across C–C unsaturated systems promoted by iridium(i) and its group IX congeners 

      Fernández Fernández, David; Mascareñas Cid, José Luis; López García, Fernando (Royal Society of Chemistry, 2020)
      Transition metal-catalyzed hydrocarbonations of unsaturated substrates have emerged as powerful synthetic tools for increasing molecular complexity in an atom-economical manner. Although this field was traditionally dominated ...
    • Catalytic Asymmetric Synthesis of Butenolides and Butyrolactones 

      Mao, Bin; Fañanás Mastral, Martín; Feringa, Ben L. (American Chemical Society, 2017-06-22)
      γ-Butenolides, γ-butyrolactones, and derivatives, especially in enantiomerically pure form, constitute the structural core of numerous natural products which display an impressive range of biological activities which are ...
    • Catalytic Cyclization of o‐Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3‐Benzazepines 

      Álvarez Pérez, Andrea; González Rodríguez, Carlos; García Yebra, Cristina; Varela Carrete, Jesús Ángel; Oñate Rodríguez, Enrique; Esteruelas Rodrigo, Miguel Ángel; Saá Rodríguez, Carlos (Wiley, 2015)
      A novel osmium‐catalyzed cyclization of o‐alkynyl phenethylamines to give 3‐benzazepines is reported. The procedure allows the straightforward preparation of a broad range of dopaminergic 3‐benzazepine derivatives. Mechanistic ...
    • Chain-branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseases 

      Estévez Cabanas, Juan Carlos; González, Marcos A.; Villaverde Cameron-Walker, María del Carmen; Hirokami, Yuki; Kato, Atsushi; Sussman, Fredy Salomon; Reza Ramos, David; Estévez Cabanas, Ramón José (MDPI, 2019)
      Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) ...
    • Characterizing aliphatic moieties in hydrocarbons with atomic force microscopy 

      Schuler, Bruno; Zhang, Yunlong; Collazos Suárez, Sara; Fatayer, Shadi; Meyer, Gehrard; Pérez Meirás, María Dolores; Guitián Rivera, Enrique; Harper, Michael R.; Kushnerick, J. Douglas; Peña Gil, Diego; Gross, Leo (Royal Society of Chemistry, 2017)
      We designed and studied hydrocarbon model compounds by high-resolution noncontact atomic force microscopy. In addition to planar polycyclic aromatic moieties, these novel model compounds feature linear alkyl and ...
    • A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC 

      Calo Lapido, Renata; Penas Tallón, Cristina; Jiménez Balsa, Adrián; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2019)
      We describe the first chemical synthesis of a functional mutant of the DNA binding domain of the oncoprotein MYC, using two alternative strategies which involve either one or two Native Chemical Ligations (NCLs). Both ...
    • Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct 

      González Bello, Concepción; Tizón, Lorena; Lence Quintana, Emilio José; Otero Casas, José Manuel; Raaij, Mark J. van; Martínez Guitián, Marta; Beceiro Casas, Alejandro; Thompson, Paul; Hawkins, Alastair R. (American Chemical Society, 2015)
      The first example of an ammonium derivative that causes a specific modification of the active site of type I dehydroquinase (DHQ1), a dehydratase enzyme that is a promising target for antivirulence drug discovery, is ...
    • Chemical solution synthesis and ferromagnetic resonance of epitaxial thin films of yttrium iron garnet 

      Lucas, Irene; Jiménez-Cavero, Pilar; Vila-Fungueiriño, José M.; Magén, Cesar; Sangiao, Soraya; Teresa, José Maria de; Morellón, Luis; Rivadulla, Francisco (APS Physics, 2017)
      We report the fabrication of epitaxial Y 3 F e 5 O 12 (YIG) thin films on G d 3 G a 5 O 12 (111) using a chemical solution method. Cubic YIG is a ferrimagnetic material at room temperature, with excellent ...
    • Chemo- and Regioselective Lysine Modification on Native Proteins 

      Matos, Maria João Correia Pinto Carvalho de; Oliveira, Bruno L.; Martínez Saéz, Nuria; Guerreiro, Ana; Cal, Pedro M.S.D.; Bertoldo, Jean Borges; Maneiro Rey, María; Perkins, Elizabeth; Howard, Julie A.; Deery, Michael J.; Chalker, Justin M.; Corzana, Francisco; Jiménez Osés, Gonzalo; Bernardes, Gonçalo J.L. (American Chemical Society, 2018)
      Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods, based on synthetic and biochemical technologies, can achieve ...
    • A chemosensor for dihydrogenphosphate based on an oxoazamacrocycle possessing three thiourea arms 

      Aldrey, Anxela; Macías, Alejandro; Bastida, Rufina; Zaragoza, Guillermo; Rama, Gustavo; Vázquez López, Miguel (Royal Society of Chemistry, 2012)
      We report a new H-bond macrocyclic chromogenic chemosensor in organic media, H3L, which displayed drastic changes in its UV–vis spectra revealing selectivity for dihydrogenphosphate over other inorganic anions, such as ...
    • Chiral Coalition in Helical Sense Enhancement of Copolymers: The Role of the Absolute Configuration of Comonomers 

      Arias, Sandra; Rodríguez Riego, Rafael; Riguera Vega, Ricardo; Quiñoá Cabana, Emilio; Freire Iribarne, Félix Manuel (American Chemistry Society, 2017-12-14)
      Both the role of the absolute configuration and the tendency of a chiral monomer to promote a certain helical scaffold in a polyphenylacetylene (PPA) —that depends on the conformational composition at the pendant group— ...
    • Chiral gold–PPA nanocomposites with tunable helical sense and morphology 

      Bergueiro Álvarez, Julián; Núñez Martínez, Manuel; Arias López, Sandra; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (Royal Society of Chemistry, 2020)
      A novel type of stimuli-responsive dynamic helical polymer–metal nanoparticle nanocomposite formed by a helical poly(phenylacetylene) (PPA) combined with gold nanoparticles (AuNPs) is described. Thus, several PPA copolymers ...
    • Chiral information harvesting in helical poly(acetylene) derivatives using oligo(p-phenyleneethynylene)s as spacers 

      Fernández Villar, Zulema; Fernández Rodríguez, Berta; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (Royal Society of Chemistry, 2020)
      A chiral harvesting transmission mechanism is described in poly(acetylene)s bearing oligo(p-phenyleneethynylene)s (OPEs) used as rigid achiral spacers and derivatized with chiral pendant groups. The chiral moieties induce ...
    • Chiral nanostructure in polymers under different deposition conditions observed using atomic force microscopy of monolayers: poly(phenylacetylene)s as a case study 

      Freire Iribarne, Félix Manuel; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo (Royal Society of Chemistry, 2016-10-31)
      Dynamic poly(phenylacetylene)s (PPAs) adopt helical structures with different elongation or helical senses depending on the types of pendants. Hence, a good knowledge of the parameters that define their structures becomes ...





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