Now showing items 69-88 of 358

    • Decoding the ECD Spectra of Poly(phenylacetylene)s: Structural Significance 

      Fernández Rodríguez, Berta; Rodríguez Riego, Rafael; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (American Chemical Society, 2019-03-13)
      The role of the main dihedral angles in the electronic circular dichroism (ECD) spectra of poly(phenylacetylene)s (PPAs) was estimated by using time-dependent density functional theory (TD-DFT) for oligo(phenylacetylene)s ...
    • Defining the Nature of Thermal Intermediate in 3 State Folding Proteins: Apoflavodoxin, a Study Case 

      García Fandiño, Rebeca; Bernadó, Pau; Ayuso Tejedor, Sara; Sancho, Javier; Orozco, Modesto (Plos, 2012)
      The early stages of the thermal unfolding of apoflavodoxin have been determined by using atomistic multi microsecondscale molecular dynamics (MD) simulations complemented with a variety of experimental techniques. Results ...
    • Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability 

      Leire, Emma; Amaral, Sandra P.; Louzao Pernas, Iria; Winzer, Klaus; Alexander, Cameron; Fernández Megía, Eduardo; Fernández Trillo, Francisco (Royal Society of Chemistry, 2016)
      Here, we evaluate how cationic gallic acid-triethylene glycol (GATG) dendrimers interact with bacteria and their potential to develop new antimicrobials. We demonstrate that GATG dendrimers functionalised with primary ...
    • Dendrimers as Innovative Radiopharmaceuticals in Cancer Radionanotherapy 

      Liko, Flonja; Hindré, François; Fernández Megía, Eduardo (American Chemical Society, 2016)
      Radiotherapy is one of the most commonly used cancer treatments, with an estimate of 40% success that could be improved further if more efficient targeting and retention of radiation at the tumor site were achieved. This ...
    • Dendrimers reduce toxicity of Aβ 1-28 peptide during aggregation and accelerate fibril formation 

      Klajnert, Barbara; Wasiak, Tomasz; Ionov, Maksim; Fernández Villamarín, Marcos; Sousa Hervés, Ana; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Elsevier, 2012-11)
      The influence of a GATG (gallic acid-triethylene glycol) dendrimer decorated with 27 terminal morpholine groups ([G3]-Mor) on the aggregation process of Alzheimer's peptide has been investigated. Amyloid fibrils were formed ...
    • A dendrimer–hydrophobic interaction synergy improves the stability of polyion complex micelles 

      Fernández Villamarín, Marcos; Sousa Hervés, Ana; Porto, Silvia; Guldris, Noelia; Martínez Costas, José Manuel; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Royal Society of Chemistry, 2017-03-28)
      Polyion complex (PIC) micelles incorporating PEG-dendritic copolymers display an unprecedented stability towards ionic strength that is amplified via hydrophobic interactions. The tridimensional orientation of peripheral ...
    • A designed DNA binding motif that recognizes extended sites and spans two adjacent major grooves 

      Rodríguez Villar, Jéssica; Mosquera Mosquera, Jesús; García Fandiño, Rebeca; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2016-02-05)
      We report the rational design of a DNA-binding peptide construct composed of the DNA-contacting regions of two transcription factors (GCN4 and GAGA) linked through an AT-hook DNA anchor. The resulting chimera, which ...
    • A designed DNA binding motif that recognizes extended sites and spans two adjacent major grooves 

      Rodríguez Villar, Jéssica; Mosquera Mosquera, Jesús; García Fandiño, Rebeca; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2016)
      We report the rational design of a DNA-binding peptide construct composed of the DNA-contacting regions of two transcription factors (GCN4 and GAGA) linked through an AT-hook DNA anchor. The resulting chimera, which ...
    • Designing Irreversible Inhibitors—Worth the Effort? 

      González Bello, Concepción (Wiley, 2016-01-07)
      Despite the unquestionable success of numerous irreversible drugs that are currently in clinical use, such as acetylsalicylic acid (Aspirin) and penicillin, the number of such approved drugs is much lower than that of ...
    • Detection of degradation markers from polymer surfaces by a novel SERS-based strategy 

      Gómez, Manuel; Reggio, Daniela; Lazzari, Massimo (Elsevier, 2019)
      This paper provides new insights for the study of polymer degradation through the detection of markers released at the polymer surface using Al-coated SERS active substrates. Combining a nanodestructive sampling procedure ...
    • Detection of phosphorylation states by intermolecular sensitization of lanthanide–peptide conjugates 

      Pazos Chantrero, Elena; Goličnik, Marko; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (Royal Society of Chemistry, 2012)
      The luminescence of a designed peptide equipped with a coordinatively-unsaturated lanthanide complex is modulated by the phosphorylation state of a serine residue in the sequence. While the phosphorylated state is weakly ...
    • Development of fluorescent probes that target serotonin 5-HT2B receptors 

      Azuaje Guerrero, Jhonny Alberto; López, Paula; Iglesias Fernández, Alba; Fuente, Rocío de la; Pérez Rubio, José M.; García Peña, Diego; Stępniewski, Tomasz Maciej; García Mera, Xerardo Xusto; Brea Floriani, José Manuel; Selent, Jana; Pérez Meirás, María Dolores; Castro Pérez, María de los Ángeles; Loza García, María Isabel; Sotelo Pérez, Eddy (Nature Publishing Group, 2017)
      Some 5-HT2B fluorescent probes were obtained by tagging 1-(2,5-dimethoxy-4-iodophenyl)-propan2-amine (DOI) with a subset of fluorescent amines. Some of the resulting fluorescent ligands showed excellent affinity and ...
    • DFT and Kinetic Monte Carlo Study of TMS-Substituted Ruthenium Vinyl Carbenes: Key Intermediates for Stereoselective Cyclizations 

      Cambeiro Cambeiro, Fermín; Martínez Núñez, Emilio; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (American Chemical Society, 2015)
      Mechanistic pathways for the cyclization of 1,5-alkynylacetal with N2CHTMS in the presence of Cp- and Cp*RuCl(cod) to afford Z and E (trimethylsilyl)vinyl spiroacetals have been calculated. Calculations show the presence ...
    • Different intracellular distribution of avian reovirus core protein sigmaA in cells of avian and mammalian origin 

      Vázquez Iglesias, Lorena; Lostalé Seijo, Irene; Martínez Costas, José Manuel; Benavente Martínez, Francisco Javier (Elsevier, 2012)
      A comparative analysis of the intracellular distribution of avian reovirus (ARV) core protein sigmaA in cells of avian and mammalian origin revealed that, whereas the viral protein accumulates in the cytoplasm and nucleolus ...
    • Different-Length Hydrazone Activated Polymers for Plasmid DNA Condensation and Cellular Transfection 

      Priegue Caamaño, Juan Manuel; Lostalé Seijo, Irene; Crisan, Daniel; Granja Guillán, Juan Ramón; Fernández Trillo, Francisco; Montenegro García, Javier (American Chemical Society, 2018)
      The recent advances in genetic engineering demand the development of conceptually new methods to prepare and identify efficient vectors for the intracellular delivery of different nucleotide payloads ranging from short ...
    • Dihydrobiphenylenes through Ruthenium‐Catalyzed [2+2+2] Cycloadditions of ortho‐Alkenylarylacetylenes with Alkynes 

      García Rubín, Silvia; González Rodríguez, Carlos; García Yebra, Cristina; Varela Carrete, Jesús Ángel; Esteruelas Rodrigo, Miguel Ángel; Saá Rodríguez, Carlos (Wiley, 2014)
      A new synthetic route to dihydrobiphenylenes has been developed. The process involves a mild RuII‐catalyzed [2+2+2] dimerization of ortho‐alkenylarylacetylenes or its more versatile variant, the Ru‐catalyzed [2+2+2] ...
    • Direct protein quantification in complex sample solutions by surface-engineered nanorod probes 

      Schrittwieser, Stefan; Pelaz García, Beatriz; Parak, Wolfgang J.; Lentijo-Mozo, Sergio; Soulantica, Katerina; Dieckhoff, Jan; Ludwig, Frank; Schotter, Joerg (Springer Nature, 2017)
      Detecting biomarkers from complex sample solutions is the key objective of molecular diagnostics. Being able to do so in a simple approach that does not require laborious sample preparation, sophisticated equipment and ...
    • Directed self-assembly of trimeric DNA-bindingchiral miniprotein helicates 

      Gómez González, Jacobo; Peña Gil, Diego; Barka, Ghofrane; Sciortino, Giuseppe; Maréchal, Jean-Didier; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Frontiers Media, 2018)
      We propose that peptides are highly versatile platforms for the precise design of supramolecular metal architectures, and particularly, for the controlled assembly of helicates. In this context, we show that the bacteriophage ...
    • Disclosing an NMR-Invisible Fraction in Chitosan and PEGylated Copolymers and Its Role on the Determination of Degrees of Substitution 

      Novoa Carballal, Ramón; Riguera Vega, Ricardo; Fernández Megía, Eduardo (American Chemical Society, 2013)
      An unexpected 1H NMR invisible fraction (IF) for chitosan (CS) and CS-g-PEG is reported. The presence of this IF is remarkable considering that solution NMR is recognized as the method of choice for studying structural ...
    • Discrete Cu(I) complexes for azide-alkyne annulations of small molecules inside mammalian cells 

      Miguel Ávila, Joan; Tomás Gamasa, María; Olmos, Andrea; Pérez, Pedro J.; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2018-01-15)
      The archetype reaction of “click” chemistry, namely, the copper-promoted azide–alkyne cycloaddition (CuAAC), has found an impressive number of applications in biological chemistry. However, methods for promoting intermolecular ...





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