Now showing items 268-287 of 358

    • Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras 

      Mosquera Mosquera, Jesús; Rodríguez Villar, Jéssica; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (WILEY-VCH Verlag GmbH, 2014-04-24)
      We report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor-groove DNA binders. The hybrid featuring the sequence of the native protein ...
    • Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides 

      Bouzada, David; Salvadó, Iria; Barka, Ghofrane; Rama, Gustavo; Martínez Costas, José Manuel; Lorca, Romina; Somoza, Álvaro; Melle-Franco, Manuel; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Royal Society of Chemistry, 2018)
      A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding ...
    • Self-Assembled Micro-Fibres by Oxime Connection of Linear Peptide Amphiphiles 

      Booth, Richard; Insua López, Ignacio; Bhak, Ghibom; Montenegro García, Javier (Royal Society of Chemistry, 2018)
      Linear peptide amphiphiles are excellent biocompatible scaffolds for the hierarchical self-assembly of one dimensional nanostructures in aqueous media. However, their structural exploration and screening of self-assembling ...
    • Self-assembling alfa,gamma-cyclic peptides that generate cavities with tunable properties 

      Rodríguez Vázquez, Nuria; García Fandiño, Rebeca; Amorín López, Manuel; Granja Guillán, Juan Ramón (Royal Society of Chemistry, 2016-01-01)
      The design and synthesis of β-sheet-based self-assembling cyclic peptides with tunable cavities is described. The incorporation of a γ-amino acid with a hydroxyl group at C2 allows the incorporation of different groups ...
    • Self-assembling molecular capsules based on alpha, gamma-Cyclic peptides 

      Ozores, Lionel Haxel; Amorín López, Manuel; Granja Guillán, Juan Ramón (American Chemical Society, 2016-12-20)
      A new capsule based on a β-sheet self-assembling cyclic peptide with the ability to recognize and release several guests is described. The host structure is composed of two self-complementary α,γ-cyclic peptides bearing a ...
    • Self-Assembly of Silver Metal Clusters of Small Atomicity on Cyclic Peptide Nanotubes 

      Cuerva, Miguel; García Fandiño, Rebeca; Vázquez Vázquez, Carlos; López Quintela, Manuel Arturo; Montenegro García, Javier; Granja Guillán, Juan Ramón (American Chemical Society, 2015-10-06)
      Subnanometric noble metal clusters, composed by only a few atoms, behave like molecular entities and display magnetic, luminescent and catalytic activities. However, non-covalent interactions of molecular metal clusters, ...
    • Self‐assembling Venturi‐like peptide nanotubes 

      Fuertes, Alberto; Ozores, Lionel Haxel; Amorín López, Manuel; Granja Guillán, Juan Ramón (Royal Society of Chemistry, 2017-01-14)
      We describe the design and synthesis of self-assembling peptide nanotubes that have an internal filter area and whose length and internal diameters, at the entrance and in the constricted area, are precisely controlled
    • Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates 

      Mosquera Mosquera, Jesús; Sánchez López, Mateo Isidro; Valero, Julián; Mendoza, Javier de; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2015-02-18)
      Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to ...
    • Sequence‐Selective DNA Recognition with Peptide–Bisbenzamidine Conjugates 

      Sánchez López, Mateo Isidro; Vázquez Vázquez, Olalla; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Wiley, 2013)
      Transcription factors (TFs) are specialized proteins that play a key role in the regulation of genetic expression. Their mechanism of action involves the interaction with specific DNA sequences, which usually takes place ...
    • Sequence‐Specific DNA Recognition with Designed Peptides 

      Boga, Sonia; Bouzada, David; García Peña, Diego; Vázquez López, Miguel; Vázquez Sentís, Marco Eugenio (Wiley, 2018)
      Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only ...
    • Sequential Induction of Chirality in Helical Polymers: From the Stereocenter to the Achiral Solvent 

      Nieto-Ortega, Belén; Rodríguez Riego, Rafael; Medina, Samara; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Casado, Juan; Freire Iribarne, Félix Manuel; Ramírez, Francisco Javier (American Chemical Society, 2018-04-13)
      Several steps of chiral induction have been detected in poly(phenylacetylene)s among their different hierarchical levels of chirality by vibrational circular dichroism, namely, (i) from the stereogenic centers to the ...
    • Simultaneous Adjustment of Size and Helical Sense of Chiral Nanospheres and Nanotubes Derived from Axially Racemic Poly(phenyl acetylene)s 

      Arias, Sandra; Núñez Martínez, Manuel; Quiñoá Cabana, Emilio; Riguera Vega, Ricardo; Freire Iribarne, Félix Manuel (Wiley, 2016-10-19)
      Nanospheres and nanotubes with full control of their size and helical sense are obtained in chloroform from the axially racemic chiral poly(phenylacetylene) poly-(R)-1 using either Ag+ as both chiral inducer and cross-linking ...
    • A Single Mutation is Sufficient to Modify the Metal Selectivity and Specificity of a Eukaryotic Manganese Superoxide Dismutase to Encompass Iron 

      Hunter, Thérèse; Bonetta, Rosalin; Sacco, Anthony; Vella, Marita; Sultana, Paul-Michael; Trinh, Chi H.; Fadia, Hava B. R.; Borowski, Tomasz; García Fandiño, Rebeca; Stockner, Thomas; Hunter, Gary J. (Wiley, 2018)
      We have generated a site‐directed mutant of the manganese superoxide dismutase SOD‐3 of C.elegans (MnSOD‐3) which modifies the metal specificity of the enzyme. While wild‐type MnSOD‐3 functions with manganese in the active ...
    • Single spin localization and manipulation in graphene open-shell nanostructures 

      Li, Jingcheng; Sanz, Sofia; Choi, Deung Jang; Corso, Martina; Peña Gil, Diego; Frederiksen, Thomas; Pascual, Jose Ignacio (Nature publishing group, 2019)
      Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion ...
    • Single‐Molecule Approach to DNA Minor‐Groove Association Dynamics 

      Bordello Malde, Jorge; Sánchez López, Mateo Isidro; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis; Al-Soufi, Wajih; Novo Rodríguez, María de la Merced (Wiley, 2012)
      Getting in the groove: Fluorescence correlation spectroscopy reveals that the dynamics of the association process of the bisbenzamidine minor‐groove binder BBA‐OG (blue with green star, see scheme) to dsDNA is not controlled ...
    • Site-selective reversible Diels–Alder reaction between a biphenylene-based polyarene and a semiconductor surface 

      Godlewski, Szymon; Engelund, Mads; Peña Gil, Diego; Zuzak, Rafał; Kawai, Hiroyo; Kolmer, Marek; Caeiro Rodríguez, Jorge; Guitián Rivera, Enrique; Vollhardt, K. Peter C.; Sánchez-Portal, Daniel; Szymonski, Marek; Pérez Meirás, María Dolores (Royal Society of Chemistry, 2018-04-28)
      Understanding the mechanisms involved in the covalent attachment of organic molecules to surfaces is a major challenge for nanotechnology and surface science. On the basis of classical organic chemistry mechanistic ...
    • Skeletal diversity in Pt- and Au-catalyzed annulations of allenedienes: dissecting unconventional mechanistic pathways 

      Nelson, Ronald; Calvelo Souto, Martín; García Fandiño, Rebeca; Lledós, Agustí; Ujaque, Gregori; Mascareñas Cid, José Luis; López García, Fernando (Royal Society of Chemistry, 2020)
      We describe the discovery of unprecedented annulation processes of 1,7-allenedienes, promoted by Pt or Au catalysts. These transformations revealed mechanistic pathways that had not been previously observed in reactions ...
    • Some Guidelines for the Synthesis and Melting Characterization of Azide Poly(ethylene glycol) Derivatives 

      González Fernández, Daniel; Torneiro Abuín, Mercedes; Lazzari, Massimo (MDPI, 2020)
      We provide fundamental guidelines in the form of a tutorial to be taken into account for the preparation and characterization of a specific class of poly(ethylene glycol) (PEG) derivatives, namely azide-terminated PEGs. ...
    • Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics 

      Méndez Ardoy, Alejandro; Bayón Fernández, Alfonso; Yu, Ziyi; Abell, Chris; Granja Guillán, Juan Ramón; Montenegro García, Javier (Wiley, 2020)
      The recent advances in the supramolecular polymerization of synthetic building blocks in aqueous conditions has given rise to new artificial and biocompatible functional materials. However, despite the importance of spatially ...
    • Specific chemical modification of bacterial type I dehydroquinase – opportunities for drug discovery 

      González Bello, Concepción (Future Science, 2015-11-24)
      Type I dehydroquinase (DHQ1) is a class I aldolase enzyme that catalyzes the reversible dehydration of 3-dehydroquinic acid to form 3-dehydroshikimic acid by multistep mechanism that involves the formation of Schiff-base ...





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