Now showing items 1-20 of 263

    • Tunneling and Conformational Flexibility Play Critical Roles in the Isomerization Mechanism of Vitamin D 

      Meana Pañeda, Rubén; Fernández Ramos, Antonio (American Chemical Society, 2011-11-27)
      The thermal isomerization reaction converting previtamin D to vitamin D is an intramolecular [1,7]-sigmatropic hydrogen shift with antarafacial stereochemistry. We have studied the dynamics of this reaction by means of the ...
    • PEG-dendritic block copolymers for biomedical applications 

      Sousa Hervés, Ana; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Royal Society of Chemistry, 2012)
      The incorporation of poly(ethylene glycol) (PEG) chains at the focal point of dendrimers results in customizable platforms where the careful selection of the PEG length, the nature of the peripheral groups, and the structure ...
    • Nonmonotonic evolution of the charge gap in ZnV2O4 under pressure 

      Kuntscher, Christine; Rabia, Kaneez; Forthaus, M.K.; Abd-Elmeguid, M. M.; Rivadulla, Francisco; Kato, Y.; Batista, Cristian D. (APS Physics, 2012)
      A2+V2O4 spinels provide a unique opportunity for studying the evolution of the charge gap of Mott insulators that approach the itinerant electron limit under the application of external pressure. Here we report ...
    • Click Chemistry for Drug Delivery Nanosystems 

      Lallana, Enrique; Sousa Hervés, Ana; Fernández Trillo, Francisco (Springer, 2012)
      The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click ...
    • A chemosensor for dihydrogenphosphate based on an oxoazamacrocycle possessing three thiourea arms 

      Aldrey, Anxela; Macías, Alejandro; Bastida, Rufina; Zaragoza, Guillermo; Rama, Gustavo; Vázquez López, Miguel (Royal Society of Chemistry, 2012)
      We report a new H-bond macrocyclic chromogenic chemosensor in organic media, H3L, which displayed drastic changes in its UV–vis spectra revealing selectivity for dihydrogenphosphate over other inorganic anions, such as ...
    • Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery 

      Lallana, Enrique; Fernández Trillo, Francisco; Sousa Hervés, Ana; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Springer, 2012)
      During the last decades, great efforts have been devoted to design polymers for reducing the toxicity, increasing the absorption, and improving the release profile of drugs. Advantage has been also taken from the inherent ...
    • Enantioselective Annulation Reactions of Bisenolates Prepared Through Dearomatization Reactions of Aromatic and Heteroaromatic Diesters 

      Pérez-Vázquez, Jaime; Veiga, Alberte X.; Prado, Gustavo; Sardina, F. Javier; Paleo, M. Rita (Wiley, 2012)
      A one‐pot, enantioselective strategy for the dearomatization–annulation of aromatic diesters to give a range of highly functionalized polycyclic molecules with excellent enantioselectivity is presented. This methodology ...
    • Orbital, charge, and spin couplings in Ru 25+O9 dimers of Ba3CoRu2O9 

      Zhou, Haidong; Kiswandhi, Andhika; Barlas, Yafis; Brooks, James; Siegrist, Theo Max; Li, G.; Balicas, Luis; Cheng, J. G.; Rivadulla, Francisco (APS Physics, 2012)
      e magnetic, transport, and structural properties of cold-pressed Ba3CoRu2O9 show (i) an antiferromagnetic transition, (ii) a semiconductor-semiconductor electronic transition where the resistivity is dominated by the ...
    • Different intracellular distribution of avian reovirus core protein sigmaA in cells of avian and mammalian origin 

      Vázquez Iglesias, Lorena; Lostalé Seijo, Irene; Martínez Costas, José Manuel; Benavente Martínez, Francisco Javier (Elsevier, 2012)
      A comparative analysis of the intracellular distribution of avian reovirus (ARV) core protein sigmaA in cells of avian and mammalian origin revealed that, whereas the viral protein accumulates in the cytoplasm and nucleolus ...
    • Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes 

      Sánchez López, Mateo Isidro; Vázquez Vázquez, Olalla; Martínez Costas, José Manuel; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2012)
      Bisbenzamidines are an important family of minor groove DNA-binding agents. We present a one-step synthesis of aromatic aza-bisbenzamidines that allows straightforward and versatile access to a large number of these ...
    • Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-Catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes 

      Francos Arias, Javier; Grande-Carmona, Francisca; Faustino, Hélio; Iglesias Sigüenza, Francisco Javier; Díez Martín, Elena; Alonso García, Isaac; Fernández Fernández, Rosario Fátima; Lassaletta, José M.; López García, Fernando; Mascareñas Cid, José Luis (American Chemical Society, 2012)
      The first highly enantioselective intermolecular (4 + 2) cycloaddition between allenes and dienes is reported. The reaction provides good yields of optically active cyclohexenes featuring diverse substitution patterns and ...
    • Gold(I)‐Catalyzed Intermolecular [2+2] Cycloadditions between Allenamides and Alkenes 

      Faustino, Hélio; Bernal Albert, Paloma; Castedo Expósito, José Luis; López García, Fernando; Mascareñas Cid, José Luis (Wiley, 2012)
      3‐(Propa‐1,2‐dien‐1‐yl)oxazolidin‐2‐one works as an efficient two‐carbon partner in a variety of intermolecular gold‐catalyzed [2+2] cycloadditions to alkenes. The transformation represents a simple and practical entry to ...
    • Palladium-Catalyzed Conjugate Addition of Terminal Alkynes to Enones 

      Villarino Palmaz, Lara; García Fandiño, Rebeca; López García, Fernando; Mascareñas Cid, José Luis (American Chemical Society, 2012)
      A practical protocol for the hydroalkynylation of enones using Pd catalysis is reported. The reaction proceeds efficiently with a variety of alkynes as well as with several cyclic and acyclic enones, providing synthetically ...
    • Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers 

      Jiménez Balsa, Adrián; Pazos Chantrero, Elena; Martínez Albardonedo, Borja; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (Wiley, 2012)
      Appending negatively charged Glu8 tails to a peptide dimer derived from the GCN4 transcription factor leads to an effective suppression of its DNA binding. The specific DNA recognition can be restored by irradiation with ...
    • In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains 

      Sánchez López, Mateo Isidro; Martínez Costas, José Manuel; González García, Francisco; Álvarez Bermúdez, María José; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (American Chemical Society, 2012)
      Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for “on demand” spatiotemporal control of their in vivo nucleic acid binding, as well as for ...
    • Single‐Molecule Approach to DNA Minor‐Groove Association Dynamics 

      Bordello Malde, Jorge; Sánchez López, Mateo Isidro; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis; Al-Soufi, Wajih; Novo Rodríguez, María de la Merced (Wiley, 2012)
      Getting in the groove: Fluorescence correlation spectroscopy reveals that the dynamics of the association process of the bisbenzamidine minor‐groove binder BBA‐OG (blue with green star, see scheme) to dsDNA is not controlled ...
    • Detection of phosphorylation states by intermolecular sensitization of lanthanide–peptide conjugates 

      Pazos Chantrero, Elena; Goličnik, Marko; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (Royal Society of Chemistry, 2012)
      The luminescence of a designed peptide equipped with a coordinatively-unsaturated lanthanide complex is modulated by the phosphorylation state of a serine residue in the sequence. While the phosphorylated state is weakly ...
    • Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: factors influencing their inhibition potency 

      Blanco Rodríguez, Beatriz; Sedes, Antía; Peón, Antonio; Lamb, Heather; Hawkins, Alastair R.; Castedo Expósito, José Luis; González Bello, Concepción (Royal Society of Chemistry, 2012-03-05)
      Several 3-alkylaryl mimics of the enol intermediate in the reaction catalyzed by type II dehydroquinase were synthesized to investigate the effect on the inhibition potency of replacing the oxygen atom in the side chain ...
    • Peripheral Functionalization of Dendrimers Regulates Internalization and Intracellular Trafficking in Living Cells 

      Albertazzi, Lorenzo; Fernández Villamarín, Marcos; Riguera Vega, Ricardo; Fernández Megía, Eduardo (American Chemical Society, 2012-04-07)
      GATG (gallic acid-triethylene glycol) dendrimers represent appealing nanostructures for biomedical applications. The incorporation of specific ligands and targeting and imaging agents on their surface has resulted in ...
    • Stereoselective Formation of Chiral Metallopeptides 

      Rama, Gustavo; Ardá, Ana; Maréchal, Jean-Didier; Gamba, Ilaria; Ishida, Hitoshi; Jiménez-Barbero, Jesús; Vázquez Sentís, Marco Eugenio; Vázquez López, Miguel (Wiley, 2012-05-03)
      Playing into our hands: The achiral bipyridine amino acid fluorenylmethyloxycarbonyl 5‐amino‐3‐oxapentanoic acid (Fmoc‐O1PenBpy‐OH) has been used for the solid‐phase synthesis of metallopeptides. Circular dichroism, molecular ...





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