Now showing items 1-20 of 358

    • Equilibrium constants and protonation site for N-methylbenzenesulfonamides 

      Moreira, José A.; Costa, Ana M. Rosa da; García Río, Luis; Pessêgo, Márcia Isabel Duarte (Beilstein Institute, 2011)
      The protonation equilibria of four substituted N-methylbenzenesulfonamides, X-MBS: X = 4-MeO (3a), 4-Me (3b), 4-Cl (3c) and 4-NO2 (3d), in aqueous sulfuric acid were studied at 25 °C by UV–vis spectroscopy. As expected, ...
    • Cyclization by Catalytic Ruthenium Carbene Insertion into Csp3-H Bonds 

      Cambeiro Cambeiro, Fermín; López Estévez, Susana; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (Wiley, 2011)
      A novel tandem Ru-catalyzed carbene addition to terminal alkynes/insertion of Csp3–H bonds in alkynyl acetals, ethers and amines has been accomplished under mild conditions. This cascade provides an efficient approach to ...
    • Tunneling and Conformational Flexibility Play Critical Roles in the Isomerization Mechanism of Vitamin D 

      Meana Pañeda, Rubén; Fernández Ramos, Antonio (American Chemical Society, 2011-11-27)
      The thermal isomerization reaction converting previtamin D to vitamin D is an intramolecular [1,7]-sigmatropic hydrogen shift with antarafacial stereochemistry. We have studied the dynamics of this reaction by means of the ...
    • Orbital, charge, and spin couplings in Ru 25+O9 dimers of Ba3CoRu2O9 

      Zhou, Haidong; Kiswandhi, Andhika; Barlas, Yafis; Brooks, James; Siegrist, Theo Max; Li, G.; Balicas, Luis; Cheng, J. G.; Rivadulla, Francisco (APS Physics, 2012)
      e magnetic, transport, and structural properties of cold-pressed Ba3CoRu2O9 show (i) an antiferromagnetic transition, (ii) a semiconductor-semiconductor electronic transition where the resistivity is dominated by the ...
    • A chemosensor for dihydrogenphosphate based on an oxoazamacrocycle possessing three thiourea arms 

      Aldrey, Anxela; Macías, Alejandro; Bastida, Rufina; Zaragoza, Guillermo; Rama, Gustavo; Vázquez López, Miguel (Royal Society of Chemistry, 2012)
      We report a new H-bond macrocyclic chromogenic chemosensor in organic media, H3L, which displayed drastic changes in its UV–vis spectra revealing selectivity for dihydrogenphosphate over other inorganic anions, such as ...
    • Nonmonotonic evolution of the charge gap in ZnV2O4 under pressure 

      Kuntscher, Christine; Rabia, Kaneez; Forthaus, M.K.; Abd-Elmeguid, M. M.; Rivadulla, Francisco; Kato, Y.; Batista, Cristian D. (APS Physics, 2012)
      A2+V2O4 spinels provide a unique opportunity for studying the evolution of the charge gap of Mott insulators that approach the itinerant electron limit under the application of external pressure. Here we report ...
    • Formation of Indoles, Dihydroisoquinolines and Dihydroquinolines by Ruthenium-Catalyzed Heterocyclizations 

      Varela Fernández, Alejandro; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (Thieme, 2012)
      Indoles, dihydroisoquinolines and dihydroquinolines were efficiently prepared by ruthenium-catalyzed heterocyclizations of aromatic homo- and bis-homopropargyl amines/amides in the presence of an amine/ammonium base-acid ...
    • Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery 

      Lallana, Enrique; Fernández Trillo, Francisco; Sousa Hervés, Ana; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Springer, 2012)
      During the last decades, great efforts have been devoted to design polymers for reducing the toxicity, increasing the absorption, and improving the release profile of drugs. Advantage has been also taken from the inherent ...
    • Click Chemistry for Drug Delivery Nanosystems 

      Lallana, Enrique; Sousa Hervés, Ana; Fernández Trillo, Francisco (Springer, 2012)
      The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click ...
    • Tandem Brønsted Acid Promoted and Nazarov Carbocyclizations of Enyneacetals to Hydroazulenones 

      Escalante Escalante, Luz Elizabeth; González Rodríguez, Carlos; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (Wiley, 2012)
      A new and efficient metal-free entry to hydroazulenones is reported. Enyneacetals were easily converted into hydroazulene skeletons by tandem Brønsted-acidpromoted carbocyclizations followed by stereospecific Nazarov ...
    • Enantioselective Annulation Reactions of Bisenolates Prepared Through Dearomatization Reactions of Aromatic and Heteroaromatic Diesters 

      Pérez-Vázquez, Jaime; Veiga, Alberte X.; Prado, Gustavo; Sardina, F. Javier; Paleo, M. Rita (Wiley, 2012)
      A one‐pot, enantioselective strategy for the dearomatization–annulation of aromatic diesters to give a range of highly functionalized polycyclic molecules with excellent enantioselectivity is presented. This methodology ...
    • PEG-dendritic block copolymers for biomedical applications 

      Sousa Hervés, Ana; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Royal Society of Chemistry, 2012)
      The incorporation of poly(ethylene glycol) (PEG) chains at the focal point of dendrimers results in customizable platforms where the careful selection of the PEG length, the nature of the peripheral groups, and the structure ...
    • Different intracellular distribution of avian reovirus core protein sigmaA in cells of avian and mammalian origin 

      Vázquez Iglesias, Lorena; Lostalé Seijo, Irene; Martínez Costas, José Manuel; Benavente Martínez, Francisco Javier (Elsevier, 2012)
      A comparative analysis of the intracellular distribution of avian reovirus (ARV) core protein sigmaA in cells of avian and mammalian origin revealed that, whereas the viral protein accumulates in the cytoplasm and nucleolus ...
    • Gold(I)‐Catalyzed Intermolecular [2+2] Cycloadditions between Allenamides and Alkenes 

      Faustino, Hélio; Bernal Albert, Paloma; Castedo Expósito, José Luis; López García, Fernando; Mascareñas Cid, José Luis (Wiley, 2012)
      3‐(Propa‐1,2‐dien‐1‐yl)oxazolidin‐2‐one works as an efficient two‐carbon partner in a variety of intermolecular gold‐catalyzed [2+2] cycloadditions to alkenes. The transformation represents a simple and practical entry to ...
    • In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains 

      Sánchez López, Mateo Isidro; Martínez Costas, José Manuel; González García, Francisco; Álvarez Bermúdez, María José; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (American Chemical Society, 2012)
      Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for “on demand” spatiotemporal control of their in vivo nucleic acid binding, as well as for ...
    • Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers 

      Jiménez Balsa, Adrián; Pazos Chantrero, Elena; Martínez Albardonedo, Borja; Mascareñas Cid, José Luis; Vázquez Sentís, Marco Eugenio (Wiley, 2012)
      Appending negatively charged Glu8 tails to a peptide dimer derived from the GCN4 transcription factor leads to an effective suppression of its DNA binding. The specific DNA recognition can be restored by irradiation with ...
    • Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes 

      Sánchez López, Mateo Isidro; Vázquez Vázquez, Olalla; Martínez Costas, José Manuel; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2012)
      Bisbenzamidines are an important family of minor groove DNA-binding agents. We present a one-step synthesis of aromatic aza-bisbenzamidines that allows straightforward and versatile access to a large number of these ...
    • Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-Catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes 

      Francos Arias, Javier; Grande-Carmona, Francisca; Faustino, Hélio; Iglesias Sigüenza, Francisco Javier; Díez Martín, Elena; Alonso García, Isaac; Fernández Fernández, Rosario Fátima; Lassaletta, José M.; López García, Fernando; Mascareñas Cid, José Luis (American Chemical Society, 2012)
      The first highly enantioselective intermolecular (4 + 2) cycloaddition between allenes and dienes is reported. The reaction provides good yields of optically active cyclohexenes featuring diverse substitution patterns and ...
    • Single‐Molecule Approach to DNA Minor‐Groove Association Dynamics 

      Bordello Malde, Jorge; Sánchez López, Mateo Isidro; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis; Al-Soufi, Wajih; Novo Rodríguez, María de la Merced (Wiley, 2012)
      Getting in the groove: Fluorescence correlation spectroscopy reveals that the dynamics of the association process of the bisbenzamidine minor‐groove binder BBA‐OG (blue with green star, see scheme) to dsDNA is not controlled ...
    • Palladium-Catalyzed Conjugate Addition of Terminal Alkynes to Enones 

      Villarino Palmaz, Lara; García Fandiño, Rebeca; López García, Fernando; Mascareñas Cid, José Luis (American Chemical Society, 2012)
      A practical protocol for the hydroalkynylation of enones using Pd catalysis is reported. The reaction proceeds efficiently with a variety of alkynes as well as with several cyclic and acyclic enones, providing synthetically ...





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