Now showing items 1-4 of 4

    • Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery 

      Lallana, Enrique; Fernández Trillo, Francisco; Sousa Hervés, Ana; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Springer, 2012)
      During the last decades, great efforts have been devoted to design polymers for reducing the toxicity, increasing the absorption, and improving the release profile of drugs. Advantage has been also taken from the inherent ...
    • Dendrimers reduce toxicity of Aβ 1-28 peptide during aggregation and accelerate fibril formation 

      Klajnert, Barbara; Wasiak, Tomasz; Ionov, Maksim; Fernández Villamarín, Marcos; Sousa Hervés, Ana; Correa, Juan; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Elsevier, 2012-11)
      The influence of a GATG (gallic acid-triethylene glycol) dendrimer decorated with 27 terminal morpholine groups ([G3]-Mor) on the aggregation process of Alzheimer's peptide has been investigated. Amyloid fibrils were formed ...
    • GATG Dendrimers and PEGylated Block Copolymers: from Synthesis to Bioapplications 

      Sousa Hervés, Ana; Novoa Carballal, Ramón; Riguera Vega, Ricardo; Fernández Megía, Eduardo (Springer, 2014)
      Dendrimers are synthetic macromolecules composed of repetitive layers of branching units that emerge from a central core. They are characterized by a tunable size and precise number of peripheral groups which determine ...
    • Liver X receptor activation with an intranasal polymer therapeutic prevents cognitive decline without altering lipid levels 

      Navas Guimaraes, María Eugenia; López Blanco, Roi; Correa Chinea, Juan Francisco; Fernández Villamarín, Marcos; Bistué, María Beatriz; Martino Adami, Pamela; Morelli, Laura; Kumar, Vijay; Wempe, Michael F.; Cuello, A. Claudio; Fernández Megía, Eduardo; Bruno, Martín Alejandro (ACS, 2021)
      The progressive accumulation of amyloid-beta (Aβ) in specific areas of the brain is a common prelude to late-onset of Alzheimer’s disease (AD). Although activation of liver X receptors (LXR) with agonists decreases Aβ ...

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