Now showing items 1-8 of 8

    • Direct protein quantification in complex sample solutions by surface-engineered nanorod probes 

      Schrittwieser, Stefan; Pelaz García, Beatriz; Parak, Wolfgang J.; Lentijo-Mozo, Sergio; Soulantica, Katerina; Dieckhoff, Jan; Ludwig, Frank; Schotter, Joerg (Springer Nature, 2017)
      Detecting biomarkers from complex sample solutions is the key objective of molecular diagnostics. Being able to do so in a simple approach that does not require laborious sample preparation, sophisticated equipment and ...
    • In situ detection of the protein corona in complex environments 

      Carril, Mónica; Prado, Daniel; Pino, Pablo del; Carrillo Carrión, Carolina; Gallego, Marta; Parak, Wolfgang J. (Springer Nature, 2017)
      Colloidal nanoparticles (NPs) are a versatile potential platform for in vivo nanomedicine. Inside blood circulation, NPs may undergo drastic changes, such as by formation of a protein corona. The in vivo corona cannot be ...
    • Investigating Possible Enzymatic Degradation on Polymer Shells around Inorganic Nanoparticles 

      Zhu, Lin; Pelaz García, Beatriz; Chakraborty, Indranath; Parak, Wolfgang J. (Universidade de Santiago de Compostela, 2019)
      Inorganic iron oxide nanoparticle cores as model systems for inorganic nanoparticles were coated with shells of amphiphilic polymers, to which organic fluorophores were linked with different conjugation chemistries, including ...
    • Nanoparticles engineered to bind cellular motors for efficient delivery 

      Dalmau-Mena, Inmaculada; Pino, Pablo del; Pelaz García, Beatriz; Cuesta-Geijo, Miguel Ángel; Galindo, Inmaculada; Moros, María; Martínez de la Fuente, Jesús; Alonso, Covadonga (BioMed Central, 2018)
      Background Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as ...
    • Novel synthesis of platinum complexes and their intracellular delivery to tumor cells by means of magnetic nanoparticles 

      Quarta, Alessandra; Amorín López, Manuel; Aldegunde Rodríguez, María José; Blasi, Laura; Ragusa, Andrea; Nitti, Simone; Pugliese, Giammarino; Granja Guillán, Juan Ramón; Pellegrino, Teresa (Royal Society of Chemistry, 2019)
      Platinum-based drugs are popular in clinics as chemotherapeutic agents to treat solid tumors. However, severe side effects such as nephro- and neurotoxicity impose strict dosage limitations that can lead to the development ...
    • Some Guidelines for the Synthesis and Melting Characterization of Azide Poly(ethylene glycol) Derivatives 

      González Fernández, Daniel; Torneiro Abuín, Mercedes; Lazzari, Massimo (MDPI, 2020)
      We provide fundamental guidelines in the form of a tutorial to be taken into account for the preparation and characterization of a specific class of poly(ethylene glycol) (PEG) derivatives, namely azide-terminated PEGs. ...
    • Synthetic materials at the forefront of gene delivery 

      Lostalé Seijo, Irene; Montenegro García, Javier (Springer Nature, 2018-09-21)
      The delivery of nucleic acids with transient activity for genetic engineering is a promising methodology with potential applications in the treatment of diseases ranging from cancer and infectious diseases to heritable ...
    • Systemically Administered Brain-Targeted Nanoparticles Transport Peptides across the Blood—Brain Barrier and Provide Neuroprotection 

      Yemisci, Muge; Caban, Secil; Gursoy-Ozdemir, Yasemin; Lule, Sevda; Novoa Carballal, Ramón; Riguera Vega, Ricardo; Fernández Megía, Eduardo; Andrieux, Karine; Couvreur, Partick; Capan, Yilmaz; Dalkara, Turgay (SAGE Publications, 2015-03-01)
      Although growth factors and anti-apoptotic peptides have been shown to be neuroprotective in stroke models, translation of these experimental findings to clinic is hampered by limited penetration of peptides to the brain. ...

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