Now showing items 1-9 of 9
Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes
(Royal Society of Chemistry, 2012)
Bisbenzamidines are an important family of minor groove DNA-binding agents. We present a one-step synthesis of aromatic aza-bisbenzamidines that allows straightforward and versatile access to a large number of these ...
MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
(American Chemical Society, 2014)
We report the discovery of a fluorogenic dye, N1,N3-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high ...
Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides
(Royal Society of Chemistry, 2018)
A set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding ...
Programmed stereoselective assembly of DNA-binding helical metallopeptides
(Royal Society of Chemistry, 2014)
A flexible and versatile synthetic approach for the construction of water-stable DNA-binding chiral peptide helicates based on the solid phase peptide synthesis (SPPS) methodology is reported
Membrane-disrupting iridium(III) oligocationic organometallopeptides
(Royal Society of Chemistry, 2016-08-19)
A series of oligoarginine peptide derivatives containing cyclometallated iridium(III) units display remarkable cytotoxicity, comparable to that of cisplatin. In vitro studies with unilamellar vesicles support a membrane-disrupting ...
In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains
(American Chemical Society, 2012)
Chemical derivatization of nucleic stains such as ethidium bromide or DAPI with tailored, photoresponsive caging groups, allows for “on demand” spatiotemporal control of their in vivo nucleic acid binding, as well as for ...
MitoBlue as a tool to analyze the mitochondria-lysosome communication
(Springer Nature, 2020)
MitoBlue is a fluorescent bisamidine that can be used to easily monitor the changes in mitochondrial degradation processes in different cells and cellular conditions. MitoBlue staining pattern is exceptional among mitochondrial ...
Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide
(Royal Society of Chemistry, 2022)
Non-canonical DNA structures, particularly 3-way junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target ...