Search
Now showing items 1-10 of 43
Biodegradable PEG–dendritic block copolymers: synthesis and biofunctionality assessment as vectors of siRNA
(Royal Society of Chemistry, 2017-07-07)
One important drawback of most of the currently used dendrimers for biomedical applications is their high stability under physiological conditions that can result in cytotoxicity or complications induced by the accumulation ...
Stepwise Filtering of the Internal Layers of Dendrimers by Transverse-Relaxation-Edited NMR
(American Chemical Society, 2013)
The characteristic distribution of transverse relaxation times (T2) within dendrimers (shorter values at the core than the periphery) can be exploited in T2-edited 1D and 2D NMR experiments for the stepwise filtering of ...
Disclosing an NMR-Invisible Fraction in Chitosan and PEGylated Copolymers and Its Role on the Determination of Degrees of Substitution
(American Chemical Society, 2013)
An unexpected 1H NMR invisible fraction (IF) for chitosan (CS) and CS-g-PEG is reported. The presence of this IF is remarkable considering that solution NMR is recognized as the method of choice for studying structural ...
Real-Time Evaluation of Binding Mechanisms in Multivalent Interactions: A Surface Plasmon Resonance Kinetic Approach
(American Chemical Society, 2013)
Multivalency is a key, ubiquitous phenomenon in nature characterized by a complex combination of binding mechanisms, with special relevance in carbohydrate–lectin recognition. Herein we introduce an original surface plasmon ...
The Dynamics of Dendrimers by NMR Relaxation: Interpretation Pitfalls
(American Chemical Society, 2013)
NMR is a powerful tool to study the dynamics of dendrimers. By analogy to linear polymers, shorter T1 relaxation times have been traditionally associated to less mobile nuclei and hence, dendrimers described with reduced ...
A new potential nano-oncological therapy based on polyamino acid nanocapsules
(Elsevier, 2013-07)
A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ...
Comparative in vitro studies on PBN loaded nanoparticles prepared by biodegradable chitosan, PLGA polymers and their PEGylated block copolymers
(Elsevier, 2014)
α-phenyl-N-tert-butyl nitrone (PBN) is a neuroprotective free radical scavenger however it has low in vivo stability and blood residence time. Aim. of this study is to develop a nanoparticle formulation by using different ...
Dendrimers reduce toxicity of Aβ 1-28 peptide during aggregation and accelerate fibril formation
(Elsevier, 2012-11)
The influence of a GATG (gallic acid-triethylene glycol) dendrimer decorated with 27 terminal morpholine groups ([G3]-Mor) on the aggregation process of Alzheimer's peptide has been investigated. Amyloid fibrils were formed ...
Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery
(Springer, 2012)
During the last decades, great efforts have been devoted to design polymers for reducing the toxicity, increasing the absorption, and improving the release profile of drugs. Advantage has been also taken from the inherent ...
Systemically Administered Brain-Targeted Nanoparticles Transport Peptides across the Blood—Brain Barrier and Provide Neuroprotection
(SAGE Publications, 2015-03-01)
Although growth factors and anti-apoptotic peptides have been shown to be neuroprotective in stroke models, translation of these experimental findings to clinic is hampered by limited penetration of peptides to the brain. ...