Now showing items 1-10 of 16
Sequence‐Specific DNA Recognition with Designed Peptides
Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only ...
Self-assembling molecular capsules based on alpha, gamma-Cyclic peptides
(American Chemical Society, 2016-12-20)
A new capsule based on a β-sheet self-assembling cyclic peptide with the ability to recognize and release several guests is described. The host structure is composed of two self-complementary α,γ-cyclic peptides bearing a ...
Recent Advances in Controlling the Internal and External Properties of Self‐Assembling Cyclic Peptide Nanotubes and Dimers
(Royal Society of Chemistry, 2017-06-07)
One of the most powerful strategies for the preparation of nanotubes is based on the stacking of flat-shaped cyclic peptide components. This strategy allows precise control of the nanotube internal diameter, the external ...
Self‐assembling Venturi‐like peptide nanotubes
(Royal Society of Chemistry, 2017-01-14)
We describe the design and synthesis of self-assembling peptide nanotubes that have an internal filter area and whose length and internal diameters, at the entrance and in the constricted area, are precisely controlled
In situ functionalized polymers for siRNA delivery
(WILEY-VCH Verlag GmbH, 2016-04-21)
A new method is reported herein for screening the biological activity of functional polymers across a consistent degree of polymerization and in situ, that is, under aqueous conditions and without purification/isolation ...
Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos
We synthesized octa‐arginine conjugates of DNA‐binding agents (bisbenzamidine, acridine and Thiazole Orange) and demonstrated that their DNA binding and cell internalization can be inhibited by appending a (negatively ...
Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras
(WILEY-VCH Verlag GmbH, 2014-04-24)
We report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor-groove DNA binders. The hybrid featuring the sequence of the native protein ...
Reversible supramolecular assembly at specific DNA sites: Ni-promoted, bivalent DNA binding with designed peptide and bipyridylbisbenzamidine components
(WILEY-VCH Verlag GmbH, 2014-07-15)
At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped ...
Self-assembling alfa,gamma-cyclic peptides that generate cavities with tunable properties
(Royal Society of Chemistry, 2016-01-01)
The design and synthesis of β-sheet-based self-assembling cyclic peptides with tunable cavities is described. The incorporation of a γ-amino acid with a hydroxyl group at C2 allows the incorporation of different groups ...