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dc.contributor.author | Sánchez López, Mateo Isidro |
dc.contributor.author | Mosquera Mosquera, Jesús |
dc.contributor.author | Vázquez Sentís, Marco Eugenio |
dc.contributor.author | Mascareñas Cid, José Luis |
dc.date.accessioned | 2014-12-05T11:53:22Z |
dc.date.available | 2017-08-29T01:00:16Z |
dc.date.issued | 2014-07-15 |
dc.identifier.citation | Sánchez, M. I., Mosquera, J., Vázquez, M. E. and Mascareñas, J. L. (2014), Reversible Supramolecular Assembly at Specific DNA Sites: Nickel-Promoted Bivalent DNA Binding with Designed Peptide and Bipyridyl–Bis(benzamidine) Components. Angew. Chem. Int. Ed., 53: 9917–9921. doi: 10.1002/anie.201405726 |
dc.identifier.issn | 1521-3773 |
dc.identifier.uri | http://hdl.handle.net/10347/11965 |
dc.description.abstract | At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility. |
dc.description.sponsorship | We are thankful for support from Spanish grants (SAF2010-20822-C02 and CTQ2012-31341), Consolider Ingenio 2010 (CSD2007-00006), the Xunta de Galicia (GRC2013-041, INCITE09 209084PR, and PGIDIT08CSA-047209PR), the ERDF, and the European Research Council (Advanced Grant 340055). J.M. and M.I.S. thank the Spanish MCINN for their Ph.D. fellowships. |
dc.language.iso | eng |
dc.publisher | WILEY-VCH Verlag GmbH |
dc.rights | © WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
dc.subject | DNA recognition |
dc.subject | Minor-groove binders |
dc.subject | Peptides |
dc.subject | Self-assembly |
dc.subject | Supramolecular chemistry |
dc.subject.classification | Materias::Investigación::23 Química::2302 Bioquímica |
dc.title | Reversible supramolecular assembly at specific DNA sites: Ni-promoted, bivalent DNA binding with designed peptide and bipyridylbisbenzamidine components |
dc.type | journal article |
dc.identifier.doi | 10.1002/anie.201405726 |
dc.relation.publisherversion | http://dx.doi.org/10.1002/anie.201405726 |
dc.type.hasVersion | AM |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Química Orgánica |
dc.description.peerreviewed | SI |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/340055 |
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