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dc.contributor.authorSánchez López, Mateo Isidro
dc.contributor.authorMosquera Mosquera, Jesús
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2014-12-05T11:53:22Z
dc.date.available2017-08-29T01:00:16Z
dc.date.issued2014-07-15
dc.identifier.citationSánchez, M. I., Mosquera, J., Vázquez, M. E. and Mascareñas, J. L. (2014), Reversible Supramolecular Assembly at Specific DNA Sites: Nickel-Promoted Bivalent DNA Binding with Designed Peptide and Bipyridyl–Bis(benzamidine) Components. Angew. Chem. Int. Ed., 53: 9917–9921. doi: 10.1002/anie.201405726
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/10347/11965
dc.description.abstractAt specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.
dc.description.sponsorshipWe are thankful for support from Spanish grants (SAF2010-20822-C02 and CTQ2012-31341), Consolider Ingenio 2010 (CSD2007-00006), the Xunta de Galicia (GRC2013-041, INCITE09 209084PR, and PGIDIT08CSA-047209PR), the ERDF, and the European Research Council (Advanced Grant 340055). J.M. and M.I.S. thank the Spanish MCINN for their Ph.D. fellowships.
dc.language.isoeng
dc.publisherWILEY-VCH Verlag GmbH
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.rights© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.subjectDNA recognition
dc.subjectMinor-groove binders
dc.subjectPeptides
dc.subjectSelf-assembly
dc.subjectSupramolecular chemistry
dc.subject.classificationMaterias::Investigación::23 Química::2302 Bioquímica
dc.titleReversible supramolecular assembly at specific DNA sites: Ni-promoted, bivalent DNA binding with designed peptide and bipyridylbisbenzamidine components
dc.typeinfo:eu-repo/semantics/article
dc.identifier.DOI10.1002/anie.201405726
dc.relation.publisherversionhttp://dx.doi.org/10.1002/anie.201405726
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.description.peerreviewedSI


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